ID A0A1U8LY49_GOSHI Unreviewed; 854 AA.
AC A0A1U8LY49;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Disease resistance protein RGA4 {ECO:0000313|RefSeq:XP_016719511.1};
GN Name=LOC107932079 {ECO:0000313|RefSeq:XP_016719511.1};
OS Gossypium hirsutum (Upland cotton) (Gossypium mexicanum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX NCBI_TaxID=3635 {ECO:0000313|Proteomes:UP000189702, ECO:0000313|RefSeq:XP_016719511.1};
RN [1] {ECO:0000313|Proteomes:UP000189702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TM-1 {ECO:0000313|Proteomes:UP000189702};
RX PubMed=25893780; DOI=10.1038/nbt.3208;
RA Li F., Fan G., Lu C., Xiao G., Zou C., Kohel R.J., Ma Z., Shang H., Ma X.,
RA Wu J., Liang X., Huang G., Percy R.G., Liu K., Yang W., Chen W., Du X.,
RA Shi C., Yuan Y., Ye W., Liu X., Zhang X., Liu W., Wei H., Wei S., Huang G.,
RA Zhang X., Zhu S., Zhang H., Sun F., Wang X., Liang J., Wang J., He Q.,
RA Huang L., Wang J., Cui J., Song G., Wang K., Xu X., Yu J.Z., Zhu Y., Yu S.;
RT "Genome sequence of cultivated Upland cotton (Gossypium hirsutum TM-1)
RT provides insights into genome evolution.";
RL Nat. Biotechnol. 33:524-530(2015).
RN [2] {ECO:0000313|RefSeq:XP_016719511.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_016719511.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_016719511.1; XM_016864022.1.
DR AlphaFoldDB; A0A1U8LY49; -.
DR PaxDb; 3635-A0A1U8LY49; -.
DR GeneID; 107932079; -.
DR KEGG; ghi:107932079; -.
DR OrthoDB; 811747at2759; -.
DR Proteomes; UP000189702; Unplaced.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0050832; P:defense response to fungus; IEA:InterPro.
DR CDD; cd14798; RX-CC_like; 1.
DR Gene3D; 1.20.5.4130; -; 1.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR039203; RGA2/3-like.
DR InterPro; IPR038005; RX-like_CC.
DR InterPro; IPR041118; Rx_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR36766:SF38; NB-ARC DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR36766; PLANT BROAD-SPECTRUM MILDEW RESISTANCE PROTEIN RPW8; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF18052; Rx_N; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 4: Predicted;
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000189702}.
FT DOMAIN 12..95
FT /note="Disease resistance N-terminal"
FT /evidence="ECO:0000259|Pfam:PF18052"
FT DOMAIN 170..414
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
SQ SEQUENCE 854 AA; 98968 MW; 339FE9D896C936EB CRC64;
MAEKFLFNIA ERVVDKIVRL TVEEVRLAFN VKTDLKKLED TMISIKAVLL DAERQQHQNE
KLRLCMGKLR DIFYDAEDVI DDFKCEALRK QDGINHPDIK NLKVRVLGSC CLSFSFSLKM
SHKIKDINGR LGELATEWKS FDLRQCSDNR HVFPRETISF VHSSDVIGRD EDKENIISML
MKPSEDQNVP VIPIVGLGGL GKTTLAQLAF NDDRVTSLFP LKIWICVSEE FDLSRLLKLI
IQSVNKGERC DGSTLDALQA RLRSLLNDKK FLLVLDDAWN ENKAKWVELR NLLRSIDGLR
QSKIIVTTRS LKVASIMSSI RPYELKGLPL EDCLTLFTKW AFNDGDERHY PNLIRIGEEI
VKKCKGVPLA VRTLGSLLFQ KTDESDWIYI RESEIWRLEQ HENDILPVMK LSYNHLPSHL
QRCLAFLSLY KKDEIYYSDR VICLWMANGL LEHPKQNQEW EDVGKRYLNE LLSRCLIQME
QDFWLYFTFK MHDLVHDLAL DVSQKECKTV NSETETVDEN VRHLLFCDEK LVGVPRVLEE
MKNVRTVIIQ DASKETKTTH ESLINLCLSN FKYLRALELR NSPLMALPNS IGTLKHLRDL
DLVGCRSLRE LPRSFDKLRS LQSLNLGDTG LKQLPDSVQR LIELRHLEIT INATHLKEIR
AGCWTSLQYL ELRCCMELEC LPEGMQYLKS LRTLVLKHCD SLVSLPRSLK FLTKLEHLYI
KFCSSMNLKM ELEEEEDKDL QLSLKTLSLF GSHALRDLPR LLLQGSSSTL QQLRIAFCPD
LSVLPAWLPN LTSLQKLEIK GCFNLWDLPE GIDRFTNLRE LTIDGCPELC KRYREYGGED
WHEISHIQKV DIYE
//
