ID A0A1U8LZJ0_GOSHI Unreviewed; 728 AA.
AC A0A1U8LZJ0;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG-like isoform X1 {ECO:0000313|RefSeq:XP_016718694.1};
GN Name=LOC107931339 {ECO:0000313|RefSeq:XP_016718694.1};
OS Gossypium hirsutum (Upland cotton) (Gossypium mexicanum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX NCBI_TaxID=3635 {ECO:0000313|Proteomes:UP000189702, ECO:0000313|RefSeq:XP_016718694.1};
RN [1] {ECO:0000313|Proteomes:UP000189702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TM-1 {ECO:0000313|Proteomes:UP000189702};
RX PubMed=25893780; DOI=10.1038/nbt.3208;
RA Li F., Fan G., Lu C., Xiao G., Zou C., Kohel R.J., Ma Z., Shang H., Ma X.,
RA Wu J., Liang X., Huang G., Percy R.G., Liu K., Yang W., Chen W., Du X.,
RA Shi C., Yuan Y., Ye W., Liu X., Zhang X., Liu W., Wei H., Wei S., Huang G.,
RA Zhang X., Zhu S., Zhang H., Sun F., Wang X., Liang J., Wang J., He Q.,
RA Huang L., Wang J., Cui J., Song G., Wang K., Xu X., Yu J.Z., Zhu Y., Yu S.;
RT "Genome sequence of cultivated Upland cotton (Gossypium hirsutum TM-1)
RT provides insights into genome evolution.";
RL Nat. Biotechnol. 33:524-530(2015).
RN [2] {ECO:0000313|RefSeq:XP_016718694.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_016718694.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Involved in the 5-carboxymethylaminomethyl modification
CC (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs.
CC {ECO:0000256|ARBA:ARBA00002739}.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- SIMILARITY: Belongs to the MnmG family.
CC {ECO:0000256|ARBA:ARBA00007653}.
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DR RefSeq; XP_016718694.1; XM_016863205.1.
DR AlphaFoldDB; A0A1U8LZJ0; -.
DR STRING; 3635.A0A1U8LZJ0; -.
DR PaxDb; 3635-A0A1U8LZJ0; -.
DR GeneID; 107931339; -.
DR KEGG; ghi:107931339; -.
DR OrthoDB; 5486689at2759; -.
DR Proteomes; UP000189702; Unplaced.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IBA:GO_Central.
DR GO; GO:0030488; P:tRNA methylation; IBA:GO_Central.
DR GO; GO:0002098; P:tRNA wobble uridine modification; IBA:GO_Central.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR Gene3D; 1.10.150.570; GidA associated domain, C-terminal subdomain; 1.
DR Gene3D; 1.10.10.1800; tRNA uridine 5-carboxymethylaminomethyl modification enzyme MnmG/GidA; 1.
DR HAMAP; MF_00129; MnmG_GidA; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR049312; GIDA_C_N.
DR InterPro; IPR004416; MnmG.
DR InterPro; IPR002218; MnmG-rel.
DR InterPro; IPR020595; MnmG-rel_CS.
DR InterPro; IPR026904; MnmG_C.
DR InterPro; IPR047001; MnmG_C_subdom.
DR InterPro; IPR044920; MnmG_C_subdom_sf.
DR InterPro; IPR040131; MnmG_N.
DR NCBIfam; TIGR00136; gidA; 1.
DR PANTHER; PTHR11806; GLUCOSE INHIBITED DIVISION PROTEIN A; 1.
DR PANTHER; PTHR11806:SF0; PROTEIN MTO1 HOMOLOG, MITOCHONDRIAL; 1.
DR Pfam; PF01134; GIDA; 1.
DR Pfam; PF13932; GIDA_C; 1.
DR Pfam; PF21680; GIDA_C_1st; 1.
DR PRINTS; PR00411; PNDRDTASEI.
DR SMART; SM01228; GIDA_assoc_3; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR PROSITE; PS01280; GIDA_1; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Reference proteome {ECO:0000313|Proteomes:UP000189702}.
FT DOMAIN 614..685
FT /note="tRNA uridine 5-carboxymethylaminomethyl modification
FT enzyme C-terminal subdomain"
FT /evidence="ECO:0000259|SMART:SM01228"
SQ SEQUENCE 728 AA; 82023 MW; CCF13B02E820E8C4 CRC64;
MSILSVHLSR LTRHHFPFSS LLFPSSRPYY HACAPSRRNL RFSVIKRFPF RCICSFPATN
SIADRNRNVE VGEEKYDVIV VGGGHAGCEA ALASARLGAK TLLLTLNIDR IAWQPCNPAV
GGLAKSQLVH EVDALGGEIG KVADRCYLQK RVLNVSRGPA VRALRTQIDK QEYAMQMKNV
VESTPNLSIR EAMVTDILLG KNDNVEGVCT FFGMNFYAPA VILTTGTFMS GKIWVGRTSM
PAGRAGESAS HGLTENLQRL GFESDRLKTG TPARVDCRTV DFSVLEPQLG DEEVSWFSFD
PDFHIEKEQM CCYLTRTTKS THQLIKDNLH ETPTYGGWVE AKGPRYCPSI EDKIVRFQDK
ESHQIFLEPE GRTVPELYVQ GFSTGLPERL QLPLLRTLPG LENCSMLRPA YAVEYDYLPA
HQCSRSLMTK KIDGLFFSGQ INGTTGYEEA AAQGIISGIN AARHSDGKPL IVLERESSYI
GTLIDDLVTK DLREPYRMLT SRSEHRLLLR SDNADSRLTP LGREIGLIDD RRWKIYQDKQ
ARISDEKKRL KTVRISGGDL AADVSHFSGQ PVKESSTLES LLKKPHIEYK LLDKHCFGNE
MLSRTEKECV EIDIKYEGFI IRQRNQLQQM VHQQHRRLPE DLDYYAMTTL SLEAREKLSK
VRPQTIGQAS RVGGVSPADI TALMIILETK RRKAQEVRRH QIRASVMVDT VENLSDTLTE
AVEQFRNT
//
