ID A0A1U8M162_GOSHI Unreviewed; 950 AA.
AC A0A1U8M162;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Vacuolar protein sorting-associated protein 41 homolog {ECO:0000256|ARBA:ARBA00029538, ECO:0000256|PIRNR:PIRNR028921};
GN Name=LOC107931930 {ECO:0000313|RefSeq:XP_016719383.1};
OS Gossypium hirsutum (Upland cotton) (Gossypium mexicanum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX NCBI_TaxID=3635 {ECO:0000313|Proteomes:UP000189702, ECO:0000313|RefSeq:XP_016719383.1};
RN [1] {ECO:0000313|Proteomes:UP000189702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TM-1 {ECO:0000313|Proteomes:UP000189702};
RX PubMed=25893780; DOI=10.1038/nbt.3208;
RA Li F., Fan G., Lu C., Xiao G., Zou C., Kohel R.J., Ma Z., Shang H., Ma X.,
RA Wu J., Liang X., Huang G., Percy R.G., Liu K., Yang W., Chen W., Du X.,
RA Shi C., Yuan Y., Ye W., Liu X., Zhang X., Liu W., Wei H., Wei S., Huang G.,
RA Zhang X., Zhu S., Zhang H., Sun F., Wang X., Liang J., Wang J., He Q.,
RA Huang L., Wang J., Cui J., Song G., Wang K., Xu X., Yu J.Z., Zhu Y., Yu S.;
RT "Genome sequence of cultivated Upland cotton (Gossypium hirsutum TM-1)
RT provides insights into genome evolution.";
RL Nat. Biotechnol. 33:524-530(2015).
RN [2] {ECO:0000313|RefSeq:XP_016719383.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_016719383.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Required for vacuolar assembly and vacuolar traffic.
CC {ECO:0000256|PIRNR:PIRNR028921}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, clathrin-coated vesicle
CC {ECO:0000256|ARBA:ARBA00004132}. Vesicle
CC {ECO:0000256|ARBA:ARBA00004373}.
CC -!- SIMILARITY: Belongs to the VPS41 family.
CC {ECO:0000256|ARBA:ARBA00009582, ECO:0000256|PIRNR:PIRNR028921}.
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DR RefSeq; XP_016719383.1; XM_016863894.1.
DR AlphaFoldDB; A0A1U8M162; -.
DR STRING; 3635.A0A1U8M162; -.
DR PaxDb; 3635-A0A1U8M162; -.
DR GeneID; 107931930; -.
DR KEGG; ghi:107931930; -.
DR OrthoDB; 8838at2759; -.
DR Proteomes; UP000189702; Unplaced.
DR GO; GO:0030136; C:clathrin-coated vesicle; IEA:UniProtKB-SubCell.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-KW.
DR GO; GO:0030897; C:HOPS complex; IBA:GO_Central.
DR GO; GO:0005770; C:late endosome; IBA:GO_Central.
DR GO; GO:0009267; P:cellular response to starvation; IBA:GO_Central.
DR GO; GO:0034058; P:endosomal vesicle fusion; IBA:GO_Central.
DR GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR GO; GO:0016236; P:macroautophagy; IBA:GO_Central.
DR GO; GO:0006623; P:protein targeting to vacuole; IBA:GO_Central.
DR GO; GO:0007034; P:vacuolar transport; IEA:UniProtKB-UniRule.
DR CDD; cd16687; RING-H2_Vps8; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR000547; Clathrin_H-chain/VPS_repeat.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR016902; VPS41.
DR InterPro; IPR045111; Vps41/Vps8.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR InterPro; IPR001841; Znf_RING.
DR PANTHER; PTHR12616; VACUOLAR PROTEIN SORTING VPS41; 1.
DR PANTHER; PTHR12616:SF1; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 41 HOMOLOG; 1.
DR Pfam; PF00637; Clathrin; 1.
DR PIRSF; PIRSF028921; VPS41; 2.
DR SMART; SM00299; CLH; 1.
DR SMART; SM00184; RING; 1.
DR SMART; SM00320; WD40; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50236; CHCR; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
PE 3: Inferred from homology;
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW Protein transport {ECO:0000256|PIRNR:PIRNR028921};
KW Reference proteome {ECO:0000313|Proteomes:UP000189702};
KW Transport {ECO:0000256|PIRNR:PIRNR028921};
KW WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT REPEAT 90..120
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT DOMAIN 871..945
FT /note="RING-type"
FT /evidence="ECO:0000259|SMART:SM00184"
FT REGION 1..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 902..939
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..36
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 902..919
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 950 AA; 106631 MW; 2C7CF3992C344AA1 CRC64;
MSPFPSDNGA EGEDERDEEE EDDVEDEEEE EEEEEEEPRL KYQRMGGSIP SFLSNEAAAC
IAVAERMIAL GTYDGTIHIL DFLGNQVKAF AAHSAAVNEL SFDKEGEYIG SCSDDGSVVI
NSLFTDEKLK FEYYRPMKAI ALDPDYARKS SRRFVAGGLA GHLYFNTKKW LGYKDQVLHS
GEGPIHAVKW RTSLVAWANN VGVKVYDAAN DQRITFIERP RCSPHPEVLL PYLVWQDDTL
LVIGWGTSVK IAAIRTNLNN GANGTYRHVT MSNMNQVDIV ASFQTSYFIS GIAPFGDALV
LLAYIPSEED GENGFSSTIP SRQQGSAQRP EVRVVTWNND ELATDALPVH GFEHYKAKDY
SLAHSPFSGS SYAGGQWAAG DEPIYYIVSP KDVVIAKPRD AEDHIAWLLQ HGRHAKALAA
AEAGQGRSEL LDEVGSKYLD HLIVERKYTE AASLCPKLLR GSATAWERWI FHFAHLRQLP
VLVPYIPTEN PRLRDTAYEV ALVALATNPA FHMDLLSTVK SWLPVIYSAL PVISAIEPQL
NTSSMTDALK EALAELYVVN GQYEKAFSLY ADLMKPDIFD LIERHNLHDS IREKVVQLMM
LDCKHAVSLL IQNRDLITPS EVVSQLLRSG NNCDSRYFLH LYLHSLFEVN PHAGKDYHDM
QVELYAEYDP KMLLPFLLSS QHYTLEKAYE ICVRRDLLKE QVFILGRMGN SKQALAVIIN
ELGDIEEAVE FVSMQHDDDL WEELIQQCLH KPEMVGVLLE HTVGNLDPLY IVNIVPNGLE
IPRLRDRLVK IITDYRTETS LRHGCNDILK ADCVDLLVKY YKEARRAVYL SNEEDDTRSK
RDASGASLPI EKTSSVRNMV VKSKTRGGGR CCLCFDPFSI QNVSVIVFFC CHAYHTTCLT
DSTDSNSNKK GTGPTSQEPY GYDNDDDEDE EDDQAGDPRM RCILCTTAAS
//
