ID A0A1U8M519_GOSHI Unreviewed; 764 AA.
AC A0A1U8M519;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=ribonuclease P {ECO:0000256|ARBA:ARBA00012179};
DE EC=3.1.26.5 {ECO:0000256|ARBA:ARBA00012179};
GN Name=LOC107933015 {ECO:0000313|RefSeq:XP_016720639.1};
OS Gossypium hirsutum (Upland cotton) (Gossypium mexicanum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX NCBI_TaxID=3635 {ECO:0000313|Proteomes:UP000189702, ECO:0000313|RefSeq:XP_016720639.1};
RN [1] {ECO:0000313|Proteomes:UP000189702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TM-1 {ECO:0000313|Proteomes:UP000189702};
RX PubMed=25893780; DOI=10.1038/nbt.3208;
RA Li F., Fan G., Lu C., Xiao G., Zou C., Kohel R.J., Ma Z., Shang H., Ma X.,
RA Wu J., Liang X., Huang G., Percy R.G., Liu K., Yang W., Chen W., Du X.,
RA Shi C., Yuan Y., Ye W., Liu X., Zhang X., Liu W., Wei H., Wei S., Huang G.,
RA Zhang X., Zhu S., Zhang H., Sun F., Wang X., Liang J., Wang J., He Q.,
RA Huang L., Wang J., Cui J., Song G., Wang K., Xu X., Yu J.Z., Zhu Y., Yu S.;
RT "Genome sequence of cultivated Upland cotton (Gossypium hirsutum TM-1)
RT provides insights into genome evolution.";
RL Nat. Biotechnol. 33:524-530(2015).
RN [2] {ECO:0000313|RefSeq:XP_016720639.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_016720639.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Endonucleolytic cleavage of RNA, removing 5'-extranucleotides
CC from tRNA precursor.; EC=3.1.26.5;
CC Evidence={ECO:0000256|ARBA:ARBA00000928};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SIMILARITY: Belongs to the PPR family. P subfamily.
CC {ECO:0000256|ARBA:ARBA00007626}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_016720639.1; XM_016865150.1.
DR AlphaFoldDB; A0A1U8M519; -.
DR STRING; 3635.A0A1U8M519; -.
DR PaxDb; 3635-A0A1U8M519; -.
DR GeneID; 107933015; -.
DR KEGG; ghi:107933015; -.
DR OrthoDB; 47419at2759; -.
DR Proteomes; UP000189702; Unplaced.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004526; F:ribonuclease P activity; IBA:GO_Central.
DR GO; GO:0001682; P:tRNA 5'-leader removal; IBA:GO_Central.
DR Gene3D; 3.40.50.11980; -; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR002885; Pentatricopeptide_rpt.
DR InterPro; IPR033443; PPR_long.
DR InterPro; IPR031595; PRORP_C.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR13547:SF7; RIBONUCLEASE P; 1.
DR PANTHER; PTHR13547; UNCHARACTERIZED; 1.
DR Pfam; PF17177; PPR_long; 2.
DR Pfam; PF16953; PRORP; 1.
DR PROSITE; PS51375; PPR; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Reference proteome {ECO:0000313|Proteomes:UP000189702};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW tRNA processing {ECO:0000256|ARBA:ARBA00022694};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 147..206
FT /note="Pentacotripeptide-repeat region of PRORP"
FT /evidence="ECO:0000259|Pfam:PF17177"
FT DOMAIN 254..399
FT /note="Pentacotripeptide-repeat region of PRORP"
FT /evidence="ECO:0000259|Pfam:PF17177"
FT REPEAT 312..346
FT /note="PPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00708"
FT DOMAIN 442..666
FT /note="PRORP"
FT /evidence="ECO:0000259|Pfam:PF16953"
FT REGION 64..97
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 123..154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 80..97
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 764 AA; 86368 MW; 617A1E8278FE0D72 CRC64;
MTSFTFTTMQ QQPIQYYFLS ITLCKYPSSA SSTHFLYPSP PKHQIPQHFI HRTRHASVRH
HFNAKLSTKH YEKKARKETG SGFSSSSRSS NGGTERNKLE NLFSSVLEEK AEKKRYVKDK
KKMGFDSSSL KSSKTMENNS VVGKKSKKDK ANSPAVHLRV QLDMCSKRGD VMGAIQLYDK
AMKEGITMGQ YHYAVLLYLC SSAAMGIVQP AKSGSGNRPV LNNGKLVDFD NSLANGSTKP
YYLEDDEIWV SEDVKKHALV KGFEIYETMC SNNVPMNEAT LTSVARMAMS MGDGDMAFDM
VKQMKPLGIN PRLRSYGPAL SVFCSTGDVN KAFEVEKHML EHGVQPEEPE LEALLRVSVG
AGKGDKVYYL LHKLRTSVRK VSPSTADIIV RWFESKAASR VGKRRIDQKL IKEAIENGGG
GWHGQGWLGK GKWSISYTVV GDDALCKCCG DKLALIDLDP IETEKFAESV ASIAIKREKN
FSFQKFQKWL DYYGPFEAVV DAANVGLFSQ KRFMPSKVNA VVNAIRQKLP SRRWPLIVLH
NKRITGRKMD EPVNKALIDK WKNADALYST PTGSNDDWYW LYAAIKFKCL IVTNDEMRDH
TFQLLGNEFF PKWKERHQVH FSFSNTSPVF YMPPPCSVVI QESEKGHWHI PIASELDYDS
ERTWLCIRRA NSHAVKEDSV AITEDSQSLN RNKEHTKSTT QTKVNSNFLP LNNGNYDKPR
KLAEEMYKNI TSISFASVSS DQHKLLSEIE AAEMRGNCVI DFQI
//
