ID A0A1U8M5R8_GOSHI Unreviewed; 344 AA.
AC A0A1U8M5R8;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Dihydroflavonol-4-reductase-like {ECO:0000313|RefSeq:XP_016722110.1};
GN Name=LOC107934244 {ECO:0000313|RefSeq:XP_016722110.1};
OS Gossypium hirsutum (Upland cotton) (Gossypium mexicanum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX NCBI_TaxID=3635 {ECO:0000313|Proteomes:UP000189702, ECO:0000313|RefSeq:XP_016722110.1};
RN [1] {ECO:0000313|Proteomes:UP000189702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TM-1 {ECO:0000313|Proteomes:UP000189702};
RX PubMed=25893780; DOI=10.1038/nbt.3208;
RA Li F., Fan G., Lu C., Xiao G., Zou C., Kohel R.J., Ma Z., Shang H., Ma X.,
RA Wu J., Liang X., Huang G., Percy R.G., Liu K., Yang W., Chen W., Du X.,
RA Shi C., Yuan Y., Ye W., Liu X., Zhang X., Liu W., Wei H., Wei S., Huang G.,
RA Zhang X., Zhu S., Zhang H., Sun F., Wang X., Liang J., Wang J., He Q.,
RA Huang L., Wang J., Cui J., Song G., Wang K., Xu X., Yu J.Z., Zhu Y., Yu S.;
RT "Genome sequence of cultivated Upland cotton (Gossypium hirsutum TM-1)
RT provides insights into genome evolution.";
RL Nat. Biotechnol. 33:524-530(2015).
RN [2] {ECO:0000313|RefSeq:XP_016722110.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_016722110.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the 3-beta-HSD family.
CC {ECO:0000256|RuleBase:RU004475}.
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DR RefSeq; XP_016722110.1; XM_016866621.1.
DR AlphaFoldDB; A0A1U8M5R8; -.
DR STRING; 3635.A0A1U8M5R8; -.
DR PaxDb; 3635-A0A1U8M5R8; -.
DR GeneID; 107934244; -.
DR KEGG; ghi:107934244; -.
DR OrthoDB; 1215685at2759; -.
DR Proteomes; UP000189702; Unplaced.
DR GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IBA:GO_Central.
DR GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR10366:SF589; CINNAMOYL-COA REDUCTASE-LIKE SNL6; 1.
DR PANTHER; PTHR10366; NAD DEPENDENT EPIMERASE/DEHYDRATASE; 1.
DR Pfam; PF01073; 3Beta_HSD; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU004475};
KW Reference proteome {ECO:0000313|Proteomes:UP000189702}.
FT DOMAIN 40..202
FT /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF01073"
SQ SEQUENCE 344 AA; 38466 MW; 44EB7E7CDFE0B831 CRC64;
MEEIEVPKPI LMPISGKEQK CVGNIFSCSF NAREKKLICV TSGNSYLGSF IVKELLAHGY
LVRVTIQHPA EFEDVKDLLG VEDLNLLESV VVTKMEKLQS LCDAFRGCHA VFHTSSFIDP
HGISGYSEQK VFLETEVART VMEACAKAAY IKRCVFTTSL LASIWRNENI DGIIDDSCWS
SEEFCREKKL WLALGKTKAE KVAWMKAKEL KVNLVTVCPG LLMAPTFPNP HIQTSIPYLK
GGQMMLQQGC LAIAEVEKVA KAHVSVYEGM NYGASGRYLC FDGVVRRQQE AIELEKGLKM
TGFLLGERHV VLSEEDEEEI PIKIRNSKLA ALLNKINQRL PCKT
//
