ID   A0A1U8M835_GOSHI        Unreviewed;       695 AA.
AC   A0A1U8M835;
DT   10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2017, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=TMV resistance protein N-like {ECO:0000313|RefSeq:XP_016722977.1};
GN   Name=LOC107934961 {ECO:0000313|RefSeq:XP_016722977.1};
OS   Gossypium hirsutum (Upland cotton) (Gossypium mexicanum).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX   NCBI_TaxID=3635 {ECO:0000313|Proteomes:UP000189702, ECO:0000313|RefSeq:XP_016722977.1};
RN   [1] {ECO:0000313|Proteomes:UP000189702}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. TM-1 {ECO:0000313|Proteomes:UP000189702};
RX   PubMed=25893780; DOI=10.1038/nbt.3208;
RA   Li F., Fan G., Lu C., Xiao G., Zou C., Kohel R.J., Ma Z., Shang H., Ma X.,
RA   Wu J., Liang X., Huang G., Percy R.G., Liu K., Yang W., Chen W., Du X.,
RA   Shi C., Yuan Y., Ye W., Liu X., Zhang X., Liu W., Wei H., Wei S., Huang G.,
RA   Zhang X., Zhu S., Zhang H., Sun F., Wang X., Liang J., Wang J., He Q.,
RA   Huang L., Wang J., Cui J., Song G., Wang K., Xu X., Yu J.Z., Zhu Y., Yu S.;
RT   "Genome sequence of cultivated Upland cotton (Gossypium hirsutum TM-1)
RT   provides insights into genome evolution.";
RL   Nat. Biotechnol. 33:524-530(2015).
RN   [2] {ECO:0000313|RefSeq:XP_016722977.1}
RP   IDENTIFICATION.
RC   TISSUE=Leaf {ECO:0000313|RefSeq:XP_016722977.1};
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_016722977.1; XM_016867488.1.
DR   AlphaFoldDB; A0A1U8M835; -.
DR   PaxDb; 3635-A0A1U8M835; -.
DR   Proteomes; UP000189702; Unplaced.
DR   GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR   GO; GO:0006952; P:defense response; IEA:InterPro.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 2.
DR   InterPro; IPR042197; Apaf_helical.
DR   InterPro; IPR044974; Disease_R_plants.
DR   InterPro; IPR002182; NB-ARC.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000157; TIR_dom.
DR   InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11017:SF580; DISEASE RESISTANCE-LIKE PROTEIN DSC1; 1.
DR   PANTHER; PTHR11017; LEUCINE-RICH REPEAT-CONTAINING PROTEIN; 1.
DR   Pfam; PF00931; NB-ARC; 1.
DR   Pfam; PF01582; TIR; 1.
DR   Pfam; PF13676; TIR_2; 1.
DR   PRINTS; PR00364; DISEASERSIST.
DR   SMART; SM00255; TIR; 2.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 2.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS50104; TIR; 2.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000189702}.
FT   DOMAIN          11..179
FT                   /note="TIR"
FT                   /evidence="ECO:0000259|PROSITE:PS50104"
FT   DOMAIN          180..349
FT                   /note="TIR"
FT                   /evidence="ECO:0000259|PROSITE:PS50104"
SQ   SEQUENCE   695 AA;  78449 MW;  15631128BAB1A602 CRC64;
     MGSSSSSSTL MKYHVFLSFR GEDTRLNFTT HLLQALKDEG LDVFFDEEKL ERGDQLSQAL
     SRAIAVSNIS IIVLSADYAS SKSCLVELSD IMDRYSVGQH IVRPIFYHVN PSDVVKIDGS
     FKKSFDEHKT KRSVDEVKQW ETAFAEVGKL QGWHIDGSRS DGPETQYIKD IVAYVMQKLM
     KHQVFLSLGE DTRLNFSNHL VNALEKVGIN VFPDNETLKK GEKLPPTYSR TISASNLSIL
     VVSKAYASSK SCLGELSDIM DRKHNPTDKH IVLPVFYHVD PSDVRNSGGH FKTSFEEHES
     EQPADRVQQW KTAFAEVGKL KGWYIEGGKF DRPETEYIKD VVEYVIKKLT NIGFESASEE
     LVGIEYQKNA ILKLIKQKDC RVIGLWGMGG QGKTTLAEAV YKKFSSEFES HWFLQNVREE
     IKKQGKESLR NEFLSELLNS NVDIGTPSIG STLTQERLNK KKVLVVLDDV DDSDQIDYMG
     VKHFGYGSKT IITSRDRQVL ESGGADTIHE VKGLNKNDSL QLFSTFAFKQ LNPAVGFQDL
     SRRFVKYSQG NPLALKVLGS DLNKRSKNYW ESKVEKLKDC PPEKKILEVL KSSYDGLDLV
     EQNIFLDIAC FFKGEPMERA KLILSSCYTG AECGINKLVD KCLINVSSST NFSLDHFDYS
     TMWPCKLLRD AISMHDTLEE MGKDIVCQES KTLGN
//