ID A0A1U8M957_GOSHI Unreviewed; 1121 AA.
AC A0A1U8M957;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Importin-5-like {ECO:0000313|RefSeq:XP_016723295.1};
GN Name=LOC107935234 {ECO:0000313|RefSeq:XP_016723295.1};
OS Gossypium hirsutum (Upland cotton) (Gossypium mexicanum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX NCBI_TaxID=3635 {ECO:0000313|Proteomes:UP000189702, ECO:0000313|RefSeq:XP_016723295.1};
RN [1] {ECO:0000313|Proteomes:UP000189702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TM-1 {ECO:0000313|Proteomes:UP000189702};
RX PubMed=25893780; DOI=10.1038/nbt.3208;
RA Li F., Fan G., Lu C., Xiao G., Zou C., Kohel R.J., Ma Z., Shang H., Ma X.,
RA Wu J., Liang X., Huang G., Percy R.G., Liu K., Yang W., Chen W., Du X.,
RA Shi C., Yuan Y., Ye W., Liu X., Zhang X., Liu W., Wei H., Wei S., Huang G.,
RA Zhang X., Zhu S., Zhang H., Sun F., Wang X., Liang J., Wang J., He Q.,
RA Huang L., Wang J., Cui J., Song G., Wang K., Xu X., Yu J.Z., Zhu Y., Yu S.;
RT "Genome sequence of cultivated Upland cotton (Gossypium hirsutum TM-1)
RT provides insights into genome evolution.";
RL Nat. Biotechnol. 33:524-530(2015).
RN [2] {ECO:0000313|RefSeq:XP_016723295.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_016723295.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_016723295.1; XM_016867806.1.
DR AlphaFoldDB; A0A1U8M957; -.
DR STRING; 3635.A0A1U8M957; -.
DR PaxDb; 3635-A0A1U8M957; -.
DR GeneID; 107935234; -.
DR KEGG; ghi:107935234; -.
DR OMA; DSCYQDD; -.
DR OrthoDB; 24319at2759; -.
DR Proteomes; UP000189702; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0061608; F:nuclear import signal receptor activity; IBA:GO_Central.
DR GO; GO:0008139; F:nuclear localization sequence binding; IBA:GO_Central.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0006606; P:protein import into nucleus; IBA:GO_Central.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000357; HEAT.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR001494; Importin-beta_N.
DR InterPro; IPR040122; Importin_beta.
DR InterPro; IPR041653; Importin_rep_4.
DR InterPro; IPR041389; Importin_rep_6.
DR InterPro; IPR007701; Interferon-rel_develop_reg_N.
DR InterPro; IPR034085; TOG.
DR PANTHER; PTHR10527:SF102; BETA-3, PUTATIVE-RELATED; 1.
DR PANTHER; PTHR10527; IMPORTIN BETA; 1.
DR Pfam; PF02985; HEAT; 1.
DR Pfam; PF13646; HEAT_2; 1.
DR Pfam; PF05004; IFRD; 1.
DR Pfam; PF18808; Importin_rep_4; 1.
DR Pfam; PF18829; Importin_rep_6; 1.
DR SMART; SM01349; TOG; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR PROSITE; PS50077; HEAT_REPEAT; 1.
DR PROSITE; PS50166; IMPORTIN_B_NT; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000189702};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 42..116
FT /note="Importin N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS50166"
FT REPEAT 424..462
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
SQ SEQUENCE 1121 AA; 124086 MW; DECCE8E00435334E CRC64;
MATDQTQLQL AQLAHILGPD STHFETLISH LMSSSNDQRS QAESLFHLAK QTHPDSLSLA
LSRVLSSSPR PELRALSAVL LRKILTPAAD YSFLFPLLAE STRAAIKASL LSSLQTEQSK
ANVKKLCDTI SDLASSVVAT RGWPELLPFL FQCVNSKNPN LEESALLIFS RLAQNVGETT
ETLIPHLNTL HSVFFNCLSN PSSCDVRIAA LSASVSFIQC ISNPKDRDAF QDLLPLMMQT
LTEALNSGLE ATAQEALELL IELAGTEPRF LRRQIMEVVG SMLQIAEAES LEEGTRHLAI
EFIITLAEAR ERAPGMMRKL PQFIRRLFWV LMNLLVDIED EPDWYNAESE DEDAGETSNY
GVGQECLDRL SISLGGNTVV PVASELFPVF LAASEWQKRH AALIALAQIA EGCSKVMIRN
LEQVVSMILN SFHDAHPRVR WAAINAIGQL STDLGPELQT QYHQRVLPAL AGAMDDFQNP
RVQAHAASAV LNFSENCTPD ILTPYLDGIV SKLLVLLQNG KQMVQEGALT ALASVADSSQ
EQFQKYYDAV MPYLKAILVN ANDKSNRMLR AKAMECISLV GMAVGKEKFR DDAKQVMDVL
MSLQVSQMES DDPTTSYMLQ AWARLCKCLG QDFLPYMSVV MPPLLQSAQL KPDVTITSAD
SDANVDDDDD ESIETITLGD RRIGIKTSVL EEKATACNML CCYADELKEG FFPWIDQVAT
TLVPLLKFYF HEEVRKAAVS AMPELLRSAK LAVEKGQAQG RNGTYIKQLT DYIIPALVEA
LHKEPEVEIC GSMLDSLNEC IEICGPFLDE GQIKCIVDEI KQVITASSAR KQERAERAKA
EDFDEEEGEM LKEENEQEEE VFGQLGDLLG TLIKTFKASF LPFFQELTSY ITPMWGKDKT
AEERRVAICI FDDIAEHCRE AALKYYDTYL PFLLEACNDE SPDVRQAAAF GVGLCAEFGG
SVFKPLIQEA LSRLNAVIRH PNALHLDNVM AYDNAVSALG KICQFHRDSI DAAQILPAWL
SCLPIKGDLI EAKIVHEQLC SMVERSDQEL LGPNNQYLPK IVSVFAEVLC AGKDLATEQT
ASRMINLIRH FQQSLPASTL ASTWSSLQPQ QQLALQSILS S
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