ID A0A1U8M9I0_GOSHI Unreviewed; 1741 AA.
AC A0A1U8M9I0;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Abnormal spindle-like microcephaly-associated protein homolog isoform X4 {ECO:0000313|RefSeq:XP_016723501.1};
GN Name=LOC107935408 {ECO:0000313|RefSeq:XP_016723501.1};
OS Gossypium hirsutum (Upland cotton) (Gossypium mexicanum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX NCBI_TaxID=3635 {ECO:0000313|Proteomes:UP000189702, ECO:0000313|RefSeq:XP_016723501.1};
RN [1] {ECO:0000313|Proteomes:UP000189702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TM-1 {ECO:0000313|Proteomes:UP000189702};
RX PubMed=25893780; DOI=10.1038/nbt.3208;
RA Li F., Fan G., Lu C., Xiao G., Zou C., Kohel R.J., Ma Z., Shang H., Ma X.,
RA Wu J., Liang X., Huang G., Percy R.G., Liu K., Yang W., Chen W., Du X.,
RA Shi C., Yuan Y., Ye W., Liu X., Zhang X., Liu W., Wei H., Wei S., Huang G.,
RA Zhang X., Zhu S., Zhang H., Sun F., Wang X., Liang J., Wang J., He Q.,
RA Huang L., Wang J., Cui J., Song G., Wang K., Xu X., Yu J.Z., Zhu Y., Yu S.;
RT "Genome sequence of cultivated Upland cotton (Gossypium hirsutum TM-1)
RT provides insights into genome evolution.";
RL Nat. Biotechnol. 33:524-530(2015).
RN [2] {ECO:0000313|RefSeq:XP_016723501.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_016723501.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR RefSeq; XP_016723501.1; XM_016868012.1.
DR GeneID; 107935408; -.
DR OrthoDB; 53079at2759; -.
DR Proteomes; UP000189702; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR CDD; cd21223; CH_ASPM_rpt1; 1.
DR Gene3D; 1.20.5.190; -; 11.
DR Gene3D; 1.10.418.10; Calponin-like domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR001715; CH_dom.
DR InterPro; IPR036872; CH_dom_sf.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR22706:SF1; ABNORMAL SPINDLE-LIKE MICROCEPHALY-ASSOCIATED PROTEIN ISOFORM X1; 1.
DR PANTHER; PTHR22706; UNCHARACTERIZED; 1.
DR Pfam; PF00307; CH; 1.
DR Pfam; PF00612; IQ; 17.
DR SMART; SM00185; ARM; 1.
DR SMART; SM00015; IQ; 22.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF47576; Calponin-homology domain, CH-domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 3.
DR PROSITE; PS50176; ARM_REPEAT; 1.
DR PROSITE; PS50021; CH; 1.
DR PROSITE; PS50096; IQ; 14.
PE 4: Predicted;
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000189702};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 367..489
FT /note="Calponin-homology (CH)"
FT /evidence="ECO:0000259|PROSITE:PS50021"
FT REPEAT 1590..1623
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REGION 40..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1741 AA; 200392 MW; D7B6A973BF37155A CRC64;
MEEEERFPPL SSSFVLKDIS NFKTPKRIPK NPQFFTACNE TPRSSSSFRY RSQPSLVPSS
SRSKAKAKLK AFQLERSQSA CKEQLKKDRS LKSLAKSLTA WLNFLFQNPE LCGCDLSING
CNESNVVRVD SAWRSPKRMR ELWWRGEESE NVVADVSSLK YSSLRSSLKE VCSFDELKQR
MQVYLSLVSC KEVFNIMTQA AKNIDGGRLK MKANCPIVTD VGVKEKATKI LMSYNPIWLR
IGLYIIFGGD SLISPEGDFS SVKDISFLKM IIEKQFFSHT GLAKAYAYNK KVEGLYRPGY
YENLGNIILK RTLLLVLILD RAKSQTSLPL NYGIDGVDGG SPLLFTVSSG IKSSRQVLHN
FLSSDVMHGE GDLLAHLVIV GYKVSHQQSA LVEFDFQVSD LFLDLQDGVR LCRVIQLLRH
DSSILMKIVV PSDTHKKNLA NCGVALQYLR EAGVMLCDED GLKITRDDVA DRDTELTLSL
LWNIFVRLQL PLLIDRTTIA SEISKIRGFN MDKLNVINST NLGMLLNWIQ AICENYGLKV
DSFSSLVNRK AIWCLLDYYF RRELSCSNKD SHETRDEKSI MSTTDYTDAV HNFVLSQKLT
AILGKFPEVL QISDLLEHNG AVSDKSVVVL LTFLLSQLIV KKNVDQLNFH ELLGCNCQTL
ERRRHSFTRR RSASSEAIVL KDRDLDITED ATKKFMIIQA WWRDMTERNY KNVVRPAAST
SSCFPAQKTS IDILREKAAI VIQSHLRRFI ERHNFLKMTK AIGLIQAVAR AWLTVKKNSE
LNKFSFAGVP EVPSELGRLV NFIGERHSFV NLRRSVLLIQ HVARIWVAQR RDASYPILIK
AAIVIQKCFR GWVVRSLHMI ENASRKCQQK GLSNSEIEAA TGIQIAWKNF VSRSLHKHTF
AATKIQSHFR GWQLKRSFMK QKQAIITIQN NFRQFKCSST FQQYKTARIE NASFKYEEKS
LSIGETEAAS RIQIAWKNFV CRYLHKQTYA ATKIQSHYRA WHLKRSFIKQ KQEIIIIQSN
FRRLKCWRAF QIAQKEFVCR SLQNQTFAAT NIQSHFRGWQ LRRSFVKQKQ AIIAIQSKLR
QLKCSNAFQQ YKMAARSAII IQSCVRRWIA QRRALRCRYL TVAIQRHCRG WLARKDLLKR
RDAVIKIQRA IRCVICQKAF HLQKLAAIEI QRAIRGQISR NKLLGASSFC AASASSYGCN
MSKGFFQSFE LKLVITSVLK LQRWWRSVLL LKLRTKSAII IQSHSRGWIA KQKAYIEMHC
IVLIQRHCRG WLVRKEFSLK RDSVIKIQRA IRCLICQKAF HLQKLAAINI QRVIRGQLSR
SRLLGASSFH AATAGSYNCK MSKGFFQSFE LKLVITSVLK LQRWWRCVML LELRTKSAII
IQSHARGWIA KRETYRQKHC IVVIQRQSRG WLVRKDVLLR RDAVIKIQRA IRSLICQKAF
HLQKLAAIDI QMGQTARSRL LVLKLQRWWR GVLLLKSRAR SVIIIQTHAR GWIARQKAYR
KRTCIVVVQS YWKGYVARKE SREQLLNLRL RMQKSAMNVD DSRRLINRLL SALSELLSMK
SIRGILHNCE TLDMATAHSL KCCEELVAAG AITILLKLIR AASRSIPDQQ VLKHALSTLR
NLARYPHLTQ LLIDTPASVE TILWELHRNK EEGYFIASQI LKKICSNENG VITVHKFPAL
LKRLYNLVEE LTRKAYNEKR NPRAVAVRDN TDRRRLKEAV ELLKLITNGY KSSKLPIAFA
M
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