ID A0A1U8MAK9_GOSHI Unreviewed; 1183 AA.
AC A0A1U8MAK9;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase {ECO:0000256|ARBA:ARBA00011982};
DE EC=3.2.2.6 {ECO:0000256|ARBA:ARBA00011982};
GN Name=LOC107935690 {ECO:0000313|RefSeq:XP_016723800.1};
OS Gossypium hirsutum (Upland cotton) (Gossypium mexicanum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX NCBI_TaxID=3635 {ECO:0000313|Proteomes:UP000189702, ECO:0000313|RefSeq:XP_016723800.1};
RN [1] {ECO:0000313|Proteomes:UP000189702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TM-1 {ECO:0000313|Proteomes:UP000189702};
RX PubMed=25893780; DOI=10.1038/nbt.3208;
RA Li F., Fan G., Lu C., Xiao G., Zou C., Kohel R.J., Ma Z., Shang H., Ma X.,
RA Wu J., Liang X., Huang G., Percy R.G., Liu K., Yang W., Chen W., Du X.,
RA Shi C., Yuan Y., Ye W., Liu X., Zhang X., Liu W., Wei H., Wei S., Huang G.,
RA Zhang X., Zhu S., Zhang H., Sun F., Wang X., Liang J., Wang J., He Q.,
RA Huang L., Wang J., Cui J., Song G., Wang K., Xu X., Yu J.Z., Zhu Y., Yu S.;
RT "Genome sequence of cultivated Upland cotton (Gossypium hirsutum TM-1)
RT provides insights into genome evolution.";
RL Nat. Biotechnol. 33:524-530(2015).
RN [2] {ECO:0000313|RefSeq:XP_016723800.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_016723800.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide;
CC Xref=Rhea:RHEA:16301, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:57967; EC=3.2.2.6;
CC Evidence={ECO:0000256|ARBA:ARBA00000404};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16302;
CC Evidence={ECO:0000256|ARBA:ARBA00000404};
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DR RefSeq; XP_016723800.1; XM_016868311.1.
DR AlphaFoldDB; A0A1U8MAK9; -.
DR PaxDb; 3635-A0A1U8MAK9; -.
DR OrthoDB; 1055564at2759; -.
DR Proteomes; UP000189702; Unplaced.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR045344; C-JID.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11017:SF559; DISEASE RESISTANCE PROTEIN (TIR-NBS-LRR CLASS) FAMILY; 1.
DR PANTHER; PTHR11017; LEUCINE-RICH REPEAT-CONTAINING PROTEIN; 1.
DR Pfam; PF20160; C-JID; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00369; LRR_TYP; 2.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51450; LRR; 1.
DR PROSITE; PS50104; TIR; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000189702};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 14..180
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 1183 AA; 134061 MW; 41E335889DB82CFE CRC64;
MSSLLSTSSS ISRKKYDVFL SFRGEDTRKN FTDHLYDALN RNGIVTFRDD PKLEAGEEIA
PELFNAIQQS WCSVIVFSET YAFSGWCLEE LAEIVKQKND KGHKVFPIFY DVDPSDLRKQ
KGKVEEAFSK HEERCKENKD KIQRWRNALT EVANIKGWHL HNRHESKFIG DVVKKISAKL
CQTYLIVHDE LVGISLPLEE LHSKINIGED DVRIIGICGM GGIGKTTLAK VAYTQMLPHF
EGKCFLADVR EVSNKHGLVS LQKQLLSQIF PDECFNFFNV HEGNAIISHR LSRNKVLVVL
DDVDNVQHLK CLVGRRDWFS LGSRIIVTTR DEHLLRSYRI DDVYKPTTLN PNDALRLFNL
KAFDSDTTPK YDFIELSKQV VHYADGLPLA LEVLGSFLCG RDIIQWRSAI ERLNQDSNKE
ILDTLRISFD GLEEREKNIF LDIACFFNGE EKDLVMKVLD GCECFPDIGI DVLIKKSLIK
VGDDNQYLRM HALLQEMGRK IVEENVLMNL ENVADCGRKG MSIMESSRML NLSDDVFSKM
KRLRLLRVLC LSNCDDLKYL SDELRLLDWT KYPLRSLPSS FQPDNLVALL LPYSRIEQLW
KGNRPLYKLK IINLKGSQNL IKTTNFTTAP YLEVLIMEGC TRLVDVHPSL GVLKRLKLLD
IRDCKSLRSL PTKIAMESLD TLILSGCSNL ARFPEIDGKM EHLKTLHLYD CYKVEYLPES
LHQAESLEEL DLSKTAIKEP PSFISQLKNL KVLYSDGSKG PCKLKRNLLS LFKVSQRGRM
NSIASMLASL SGLSSLTKLA VRGCNLGEGY IPSAISCLSS LAFLDLRDNN FNRIPASLTG
LSKLEELSLS SCGLCNMGEG DIASDISGLS SLKVLYLNGN NFTSIAASLA RLSNLQYLGV
CNCRELESLP VLLTRKTSDW KHNWSYFLAI NSNRLAENMS AITLLKTHIK AFAKSRERFD
VIIPGNEIPE WFSQQRGGSV IEIPLPLNIQ NDSRWIGVAF CCIFGDDKGS EIKVIGGPTY
IHSRYSGQSS SNGSVFQVKN SRKVDFSFLN FVGRCITKDH LYLRYFSALS LKDKCETNNL
SLEMSFQSSP KGYPSVKVKK CGVRIMYEKD LEEIEELQCH AIQSSPNLEH IHHHSTENDG
SAGSTSLVKR KRDIDVETEE EGPHPKRMQN IFNFITDRSG KKQ
//
