ID A0A1U8MNJ3_GOSHI Unreviewed; 1230 AA.
AC A0A1U8MNJ3;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=DNA mismatch repair protein MLH3-like isoform X1 {ECO:0000313|RefSeq:XP_016728411.1};
GN Name=LOC107939586 {ECO:0000313|RefSeq:XP_016728411.1};
OS Gossypium hirsutum (Upland cotton) (Gossypium mexicanum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX NCBI_TaxID=3635 {ECO:0000313|Proteomes:UP000189702, ECO:0000313|RefSeq:XP_016728411.1};
RN [1] {ECO:0000313|Proteomes:UP000189702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TM-1 {ECO:0000313|Proteomes:UP000189702};
RX PubMed=25893780; DOI=10.1038/nbt.3208;
RA Li F., Fan G., Lu C., Xiao G., Zou C., Kohel R.J., Ma Z., Shang H., Ma X.,
RA Wu J., Liang X., Huang G., Percy R.G., Liu K., Yang W., Chen W., Du X.,
RA Shi C., Yuan Y., Ye W., Liu X., Zhang X., Liu W., Wei H., Wei S., Huang G.,
RA Zhang X., Zhu S., Zhang H., Sun F., Wang X., Liang J., Wang J., He Q.,
RA Huang L., Wang J., Cui J., Song G., Wang K., Xu X., Yu J.Z., Zhu Y., Yu S.;
RT "Genome sequence of cultivated Upland cotton (Gossypium hirsutum TM-1)
RT provides insights into genome evolution.";
RL Nat. Biotechnol. 33:524-530(2015).
RN [2] {ECO:0000313|RefSeq:XP_016728411.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_016728411.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082}.
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DR RefSeq; XP_016728411.1; XM_016872922.1.
DR AlphaFoldDB; A0A1U8MNJ3; -.
DR STRING; 3635.A0A1U8MNJ3; -.
DR PaxDb; 3635-A0A1U8MNJ3; -.
DR OrthoDB; 9570at2759; -.
DR Proteomes; UP000189702; Unplaced.
DR GO; GO:0032300; C:mismatch repair complex; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IBA:GO_Central.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IBA:GO_Central.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF47; DNA MISMATCH REPAIR PROTEIN MLH3; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW Reference proteome {ECO:0000313|Proteomes:UP000189702}.
FT DOMAIN 214..349
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT DOMAIN 989..1149
FT /note="MutL C-terminal dimerisation"
FT /evidence="ECO:0000259|SMART:SM00853"
SQ SEQUENCE 1230 AA; 138263 MW; 30860EDEBF17E7AD CRC64;
MGSIKPLPDA VRSTVRSATI LFDLTRVVEE LIFNSLDAAA TKVSVFLSVG SSYVKVVDDG
SGISRDGLVL LGERYVTSKL NHLSDLDAAG SSFGFRGEAL ASISDVALVE IVTKAYGRPN
GYRKVIKGSK CLYLGIDDDR KDMGTTVVVR DLFCNQPVRK KQMQSSPKKV LQSVKKCVFR
IALVHPMVYF NLIDIESEDE LLSVNPSSSP LPLLMSGLGI EDCACLQKLN ASDGSLKLSG
YISGPCDDFT SKAFQYVYIN SRLVCKGPIH KLLNNLSTSF ESLHPEKANN WTKNGKRSRS
QVVPSYIINI SCPPSFYDLT FEPSKTYVEF KDWKPVCTLI ETAVQHLWRK NISYVDGLGQ
AETLKEDVNI LNVAEDFFDG SSVDLEFATR KRTKKYQPSS SLDKLTIDNL FHMDREDTPF
EECNGNTAQF KDQQNDMKFV HWTDYSFQSL GDSLSKGGSV VNQRSDWHLW SSDNNILAED
HFLENRFIAS GRPNYHVNNN NISSKLGNES LKFESCVTNE TVRSVFPFDS REVCNDMQFR
KNISKPFMQS CSFQRNQPLD RELVESDVGV DSPIDSLKTK RKWVCSNDGF NMMEVDFSDQ
TFDHLSKTAW QDGPKLVGTD NIPMDCDVLR GASAKLFLSC GDVSVEENGL VSGSVMLAEN
FASSHQFLSL GLRSGTSNLF AQFSYKNAIE GSFRSEKRTN FGHFSDGEDK DNQFGFDLIS
RGSSQEKCIH DFPNTEQGID YAESSREFSE HLQQDNLKHK FSPEQFNVVI EDGDWPCSDS
SINEHKRKRD CFRYQDFGKN FSPKERSRRS QSAPPFYIRK RRFISLHHCL QTSEESTSNE
VRGPYTFLET GDKKPPQHSS GLHNRCFEPN FGKNRSNMNN KPDKVHGPIV QKCDKIEQPY
CREDPELVPV QGISVLSPEE ILVFKLFPSY GNQDPLISGT KWRKTRNNKL YDADNEDTLL
DIASGFLNLA AESLVPKSII KKCLTEAKVL QQVDKKFIPI VAGGKLAIID QHAADERIQL
EELRRKVLSG EGKSVAYLDT EKELILPEMG YQLLHNFSEQ IRHWGWICDF HTQDSRSFKK
NLNLIQRKPA VVILLAVPCI LGVNLSDVDL LEFLHQLADT DGSSTMPPSV SRILNSKACR
GAIMFGDSLL PSECSLIVEE LKQTSLCFQC AHGRPTTAPL VNLEALHGQI AKMQVRDDEG
RELWHGLCRQ GVSLERASLR LRAAADEKPS
//
