ID A0A1U8MS25_GOSHI Unreviewed; 785 AA.
AC A0A1U8MS25;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=LOC107939510 {ECO:0000313|RefSeq:XP_016728343.1};
OS Gossypium hirsutum (Upland cotton) (Gossypium mexicanum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX NCBI_TaxID=3635 {ECO:0000313|Proteomes:UP000189702, ECO:0000313|RefSeq:XP_016728343.1};
RN [1] {ECO:0000313|Proteomes:UP000189702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TM-1 {ECO:0000313|Proteomes:UP000189702};
RX PubMed=25893780; DOI=10.1038/nbt.3208;
RA Li F., Fan G., Lu C., Xiao G., Zou C., Kohel R.J., Ma Z., Shang H., Ma X.,
RA Wu J., Liang X., Huang G., Percy R.G., Liu K., Yang W., Chen W., Du X.,
RA Shi C., Yuan Y., Ye W., Liu X., Zhang X., Liu W., Wei H., Wei S., Huang G.,
RA Zhang X., Zhu S., Zhang H., Sun F., Wang X., Liang J., Wang J., He Q.,
RA Huang L., Wang J., Cui J., Song G., Wang K., Xu X., Yu J.Z., Zhu Y., Yu S.;
RT "Genome sequence of cultivated Upland cotton (Gossypium hirsutum TM-1)
RT provides insights into genome evolution.";
RL Nat. Biotechnol. 33:524-530(2015).
RN [2] {ECO:0000313|RefSeq:XP_016728343.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_016728343.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_016728343.1; XM_016872854.1.
DR AlphaFoldDB; A0A1U8MS25; -.
DR STRING; 3635.A0A1U8MS25; -.
DR PaxDb; 3635-A0A1U8MS25; -.
DR OrthoDB; 297760at2759; -.
DR Proteomes; UP000189702; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 4.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR013210; LRR_N_plant-typ.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR PANTHER; PTHR27008; OS04G0122200 PROTEIN; 1.
DR PANTHER; PTHR27008:SF497; OS10G0337400 PROTEIN; 1.
DR Pfam; PF00560; LRR_1; 11.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF08263; LRRNT_2; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR PRINTS; PR00019; LEURICHRPT.
DR SMART; SM00369; LRR_TYP; 7.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Kinase {ECO:0000313|RefSeq:XP_016728343.1};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Receptor {ECO:0000313|RefSeq:XP_016728343.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000189702};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transferase {ECO:0000313|RefSeq:XP_016728343.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 661..682
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 714..785
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT BINDING 743
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 785 AA; 85610 MW; AF36A5FA70922A80 CRC64;
MESSKKHFQT SSSFFLMVLL SFFNLQGLNL LRLATASPLV RGNDTDQQAL IQFKAKITGD
QLNIMESWNS SIHFCQWIGV TCGRKHPRVT KLKLRVLKLS GSLSPYIVNL SFLKELDLAG
NSFYNQIPRE IGGLRRLEAL DLANNSISGE IPSNLSACSK LILVDMSNNQ LTGEIPSLLD
LLSNLKVLGF VNNSLRGSIP PSLGNLSSLE KLGLENNALS GIIPEPFGRL RNLSVFAISS
NAISGIVPVA MFNLSNIRAF DIGINKIQGT LHSDLEINMP YVEFFSVGGN QISGQIPISL
SNATYLYDLE FNGNRFNGNV PSLEKLDTLY NLELGKNYLG HGREGDLNFL CSLVNNTKLR
FLSIGNNNFG GEFPKCISNF SSTLRGLSMG DNNILGKIPD GIGNLINLEV LVFAINQLSG
PIPFNIGRLQ KLKIFLANIN FLSGTIPHSI GNLSELILLD LNFNNLQGSI PSGLGNCKNL
LLMDLSSNKL SGPIPPEVLG LPSLSIVLNL SSNYLTGELS VVVEKLKVLS ILDVSQNRLS
GLLPKNLGSC VSLEKLFLEG NLFEGPIPLS LSSLRGLEAL DLSDNYLSGG IPEFLVRFGA
LKYLNLSFND LEGLIPSEGV FKNTSATFVE GNSKLCGGIP ELHLSRCNSK KSSKTSLKLK
ITIMVVISGV TSVFSIFLII WFRMKKEQKP MTTHVENSLL QLSYQSILRT TNGFSPQNLV
GSGSFGSVYK GILEANGAVI AVKVFNLLNH RASRSFLIEC EALKNIRHRN LVKLGGLATS
ICWHE
//
