ID A0A1U8MV80_GOSHI Unreviewed; 574 AA.
AC A0A1U8MV80;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=MLO-like protein {ECO:0000256|RuleBase:RU280816};
GN Name=LOC107941659 {ECO:0000313|RefSeq:XP_016730723.1,
GN ECO:0000313|RefSeq:XP_016730724.1, ECO:0000313|RefSeq:XP_016730725.1};
GN Synonyms=MLO {ECO:0000256|RuleBase:RU280816};
OS Gossypium hirsutum (Upland cotton) (Gossypium mexicanum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX NCBI_TaxID=3635 {ECO:0000313|Proteomes:UP000189702, ECO:0000313|RefSeq:XP_016730725.1};
RN [1] {ECO:0000313|Proteomes:UP000189702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TM-1 {ECO:0000313|Proteomes:UP000189702};
RX PubMed=25893780; DOI=10.1038/nbt.3208;
RA Li F., Fan G., Lu C., Xiao G., Zou C., Kohel R.J., Ma Z., Shang H., Ma X.,
RA Wu J., Liang X., Huang G., Percy R.G., Liu K., Yang W., Chen W., Du X.,
RA Shi C., Yuan Y., Ye W., Liu X., Zhang X., Liu W., Wei H., Wei S., Huang G.,
RA Zhang X., Zhu S., Zhang H., Sun F., Wang X., Liang J., Wang J., He Q.,
RA Huang L., Wang J., Cui J., Song G., Wang K., Xu X., Yu J.Z., Zhu Y., Yu S.;
RT "Genome sequence of cultivated Upland cotton (Gossypium hirsutum TM-1)
RT provides insights into genome evolution.";
RL Nat. Biotechnol. 33:524-530(2015).
RN [2] {ECO:0000313|RefSeq:XP_016730723.1, ECO:0000313|RefSeq:XP_016730724.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_016730723.1,
RC ECO:0000313|RefSeq:XP_016730724.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: May be involved in modulation of pathogen defense and leaf
CC cell death. {ECO:0000256|RuleBase:RU280816}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU280816}; Multi-
CC pass membrane protein {ECO:0000256|RuleBase:RU280816}.
CC -!- DOMAIN: The C-terminus contains a calmodulin-binding domain, which
CC binds calmodulin in a calcium-dependent fashion.
CC {ECO:0000256|RuleBase:RU280816}.
CC -!- SIMILARITY: Belongs to the MLO family. {ECO:0000256|ARBA:ARBA00006574,
CC ECO:0000256|RuleBase:RU280816}.
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DR RefSeq; XP_016730723.1; XM_016875234.1.
DR RefSeq; XP_016730724.1; XM_016875235.1.
DR RefSeq; XP_016730725.1; XM_016875236.1.
DR STRING; 3635.A0A1U8MV80; -.
DR PaxDb; 3635-A0A1U8MV80; -.
DR GeneID; 107941659; -.
DR KEGG; ghi:107941659; -.
DR OMA; ALCLCSY; -.
DR OrthoDB; 368831at2759; -.
DR Proteomes; UP000189702; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0009607; P:response to biotic stimulus; IEA:UniProtKB-KW.
DR InterPro; IPR004326; Mlo.
DR PANTHER; PTHR31942; MLO-LIKE PROTEIN 1; 1.
DR PANTHER; PTHR31942:SF49; MLO-LIKE PROTEIN 8; 1.
DR Pfam; PF03094; Mlo; 1.
PE 3: Inferred from homology;
KW Calmodulin-binding {ECO:0000256|RuleBase:RU280816};
KW Membrane {ECO:0000256|RuleBase:RU280816, ECO:0000256|SAM:Phobius};
KW Pathogenesis-related protein {ECO:0000256|ARBA:ARBA00023265,
KW ECO:0000256|RuleBase:RU280816};
KW Plant defense {ECO:0000256|RuleBase:RU280816};
KW Reference proteome {ECO:0000313|Proteomes:UP000189702};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|RuleBase:RU280816, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|RuleBase:RU280816,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..574
FT /note="MLO-like protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5010665955"
FT TRANSMEM 39..62
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 83..102
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 171..192
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 294..313
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 319..337
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 378..402
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 414..442
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 469..516
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 551..574
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 480..512
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 574 AA; 65599 MW; B444B72BBACAAAF2 CRC64;
MKGVLLWYCS WVWLTMEGGK VMGATESSGE RKLDQTPTWA VAGVCAVIII ISIVLETVLN
KLGTWFTERH KSALFEALDK VKAELMVLGF ISLLLTFGQS YIARICIPID VANTMLPCKS
DSEKDTSESS EEEHRRRLLW FDRRSLSTIS TAPKCKEGHE PLISVEGLHE LHILIFFLAV
FHVLYSFVTM MLGRLKIRGW KVWEQETLSH DYEFSNDPSR FRLTHETSFV KAHTSFWTRI
PFFFYIGCFF RQFFRSVGRV DYLTLRNGFI NVHLAPGSKF NFQKYIKRSL EDDFKIVVGV
SPVLWASFVV YLLLNVRGWH ALFWASLVPV IIILAVGTKL QAILTKMALE ITERHAVVQG
MPLVQASDQY FWFGRPQLVL HLIHFALFQN AFQITYFLWI WYAFGIKSCF HADFTLAIIK
VSLGVGVLCL CSYITLPLYA LVTQMGLRMK KSIFDEQTSK ALKKWHMAAK KRGNARKSPT
RALGGSTSPS STLHSTGHSL HRYKTTGHST HSSYNYEDRD MSDLEAEPLT PTSTNLIIRV
DHDEQATEIT ETYHTEARNE DDFSFAKPAP AKEP
//
