ID A0A1U8MVZ3_GOSHI Unreviewed; 915 AA.
AC A0A1U8MVZ3;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Endoplasmic reticulum metallopeptidase 1-like {ECO:0000313|RefSeq:XP_016729749.1};
GN Name=LOC107940805 {ECO:0000313|RefSeq:XP_016729749.1};
OS Gossypium hirsutum (Upland cotton) (Gossypium mexicanum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX NCBI_TaxID=3635 {ECO:0000313|Proteomes:UP000189702, ECO:0000313|RefSeq:XP_016729749.1};
RN [1] {ECO:0000313|Proteomes:UP000189702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TM-1 {ECO:0000313|Proteomes:UP000189702};
RX PubMed=25893780; DOI=10.1038/nbt.3208;
RA Li F., Fan G., Lu C., Xiao G., Zou C., Kohel R.J., Ma Z., Shang H., Ma X.,
RA Wu J., Liang X., Huang G., Percy R.G., Liu K., Yang W., Chen W., Du X.,
RA Shi C., Yuan Y., Ye W., Liu X., Zhang X., Liu W., Wei H., Wei S., Huang G.,
RA Zhang X., Zhu S., Zhang H., Sun F., Wang X., Liang J., Wang J., He Q.,
RA Huang L., Wang J., Cui J., Song G., Wang K., Xu X., Yu J.Z., Zhu Y., Yu S.;
RT "Genome sequence of cultivated Upland cotton (Gossypium hirsutum TM-1)
RT provides insights into genome evolution.";
RL Nat. Biotechnol. 33:524-530(2015).
RN [2] {ECO:0000313|RefSeq:XP_016729749.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_016729749.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_016729749.1; XM_016874260.1.
DR AlphaFoldDB; A0A1U8MVZ3; -.
DR STRING; 3635.A0A1U8MVZ3; -.
DR PaxDb; 3635-A0A1U8MVZ3; -.
DR GeneID; 107940805; -.
DR KEGG; ghi:107940805; -.
DR OMA; IKEGFAC; -.
DR OrthoDB; 277019at2759; -.
DR Proteomes; UP000189702; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008235; F:metalloexopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IBA:GO_Central.
DR CDD; cd03875; M28_Fxna_like; 1.
DR Gene3D; 3.40.630.10; Zn peptidases; 1.
DR InterPro; IPR048024; Fxna-like_M28_dom.
DR InterPro; IPR045175; M28_fam.
DR InterPro; IPR007484; Peptidase_M28.
DR PANTHER; PTHR12147:SF57; 24 KDA VACUOLAR PROTEIN-LIKE; 1.
DR PANTHER; PTHR12147; METALLOPEPTIDASE M28 FAMILY MEMBER; 1.
DR Pfam; PF04389; Peptidase_M28; 1.
DR SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00023049};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000189702};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 45..62
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 415..435
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 442..462
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 474..498
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 585..614
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 626..648
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 660..680
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 171..358
FT /note="Peptidase M28"
FT /evidence="ECO:0000259|Pfam:PF04389"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 915 AA; 100643 MW; D630EB0FDDF12B07 CRC64;
MRRRPESSST APDTSAKKSS GTSKTDEEAK LNHGIQIRTA RRSGFTWLTL FAVIVYSSWA
VYQYQYENLP VPLTAEQAGK RGFSEVAAMK HVKALTELGP HTIGSDAIEL ALQYVLAELE
NIKKTAHWEV DVEVDLFHVN VGATRLDSGM FVDRTIIYSD LDHIVLRMLP KYAPEARENA
ILVSSHIDTV FSTEGAGDCS SCVSVMLELA RGISQWAHGF KNAVIFLFNT GEEEGLSGAH
SFITQHPWST TIRMAIDLEA MGIGGKSAIF QAGPHPLAVE TFASVAKYPS GNIIFQDIFS
SGVIKSATDF QVYREVAGLS GLDFVYADHG AVYHTKNDKL KLLKSGSLQH LGENMLAFLL
QISTSSHLSK ANATVDDIQS SHDSAVYYDI LGQYMVIYRQ RFANMLHSSV ILQSLLIWTT
SLLMGGSTAA VSLAFSCLSN ILMWIFSISF SVLAAFILPL ISSSPLPYIS IPSLVLGLFA
APAFLGALTG QHLGYLVLKR YLSNVYAKRK QLSPAIQADL IKLETERWLF KAGSLQWLVL
LVIGTYYKIG SSYLALVWLV PPAFAYGLLE ATLTPGRLPK PLKLATLWMG LAIPILVSAG
QVIKLTTVII GLSVRFIRHP GGTPEWLPSL GLSLFIAVVI CLTLVYLLSY IHLSGAKTSI
VLSTCILFAL SLAVVFSGII PPFTEETARA VNLVHVVDTT GGFGEKPNSY ISLFSFTPGK
FTKEVEEIKE GFACGRHNAI DYVTFSVKYG CLTYDGTEEG WDESNIPTLD VVKDINGDKR
ITQVKIDTKR SIRWFLAINT EEIEDFTFNV GLEELVAADG KRSIDGWHTI QASGGKNAPT
KFELTLFWLQ NSTRRSDKMV QSEQRPLLRI RTDLPGVVTP KVETVLEKLP PWYSLFGKST
SPHTLSFLSS LPIDF
//
