ID A0A1U8MYC9_GOSHI Unreviewed; 773 AA.
AC A0A1U8MYC9;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Receptor-like serine/threonine-protein kinase ALE2 {ECO:0000313|RefSeq:XP_016731816.1};
GN Name=LOC107942627 {ECO:0000313|RefSeq:XP_016731816.1};
OS Gossypium hirsutum (Upland cotton) (Gossypium mexicanum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX NCBI_TaxID=3635 {ECO:0000313|Proteomes:UP000189702, ECO:0000313|RefSeq:XP_016731816.1};
RN [1] {ECO:0000313|Proteomes:UP000189702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TM-1 {ECO:0000313|Proteomes:UP000189702};
RX PubMed=25893780; DOI=10.1038/nbt.3208;
RA Li F., Fan G., Lu C., Xiao G., Zou C., Kohel R.J., Ma Z., Shang H., Ma X.,
RA Wu J., Liang X., Huang G., Percy R.G., Liu K., Yang W., Chen W., Du X.,
RA Shi C., Yuan Y., Ye W., Liu X., Zhang X., Liu W., Wei H., Wei S., Huang G.,
RA Zhang X., Zhu S., Zhang H., Sun F., Wang X., Liang J., Wang J., He Q.,
RA Huang L., Wang J., Cui J., Song G., Wang K., Xu X., Yu J.Z., Zhu Y., Yu S.;
RT "Genome sequence of cultivated Upland cotton (Gossypium hirsutum TM-1)
RT provides insights into genome evolution.";
RL Nat. Biotechnol. 33:524-530(2015).
RN [2] {ECO:0000313|RefSeq:XP_016731816.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_016731816.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_016731816.1; XM_016876327.1.
DR AlphaFoldDB; A0A1U8MYC9; -.
DR STRING; 3635.A0A1U8MYC9; -.
DR PaxDb; 3635-A0A1U8MYC9; -.
DR OrthoDB; 472728at2759; -.
DR Proteomes; UP000189702; Unplaced.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd14066; STKc_IRAK; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR47989; OS01G0750732 PROTEIN; 1.
DR PANTHER; PTHR47989:SF40; RECEPTOR-LIKE SERINE_THREONINE-PROTEIN KINASE ALE2; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|RefSeq:XP_016731816.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Receptor {ECO:0000313|RefSeq:XP_016731816.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000189702};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 279..302
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 370..645
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 88..118
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 720..742
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 88..106
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 720..734
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 398
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 773 AA; 84607 MW; 96E961867A7615EA CRC64;
MVHDGRLISL PFYFSLFSEL QVFSYPLQPV HRLSVVETIV DHARLISMRV LFSQPRSPQD
HVNPSFGPAT APAPSPIYQA PVASPSRHLV PRHRHGGHHH RHHVKPRTDA PSPSEQGCDQ
KCVDPLTATP FGSPCGCVFP MKVKLLLSVA PYAVFPVMNE LEIEVAAGLY LQQSQVKIMG
ATADAQDQGR TLVEINVVPL GEKFDNTTAI LTSDRLLHKR LSLNSTLFGT YDVVSISYPG
VPPSPPYGNI FGSGPTGSTG DLPITANFVN KNQKMNIRII AIIVLSAFVL LLVLAGAISV
LIKWRKVRRP SNAVGPAFPS SLNKRSGIGS MLSSSITSSP SMSLISTMAT CALPVKTFTL
VELEKATSNF SSKRILGEGG FGRVYRGVME DGSEVAVKLL TRDNQNGDRE FIAEVEMLSR
LHHRNLVKLV GICIEGRIRC LVYELVPNGS VESHLHGVDK NKGPLDWDAR LKIALGAARG
LAYLHEDSNP RVIHRDFKAS NVLLEDDFTP KVSDFGLARE ATEGSQHIST RVMGTFGYVA
PEYAMTGHLL VKSDVYSFGV VLLELLTGRK PVDMSQPQGQ ENLVTWARPL LSSREGVEQL
VDPSLAGTYN FDDMAKVAAI ASMCVHPEVT HRPFMGEVVQ ALKLIYNDTD ETGGDCCSQK
ESSAPESDFK GDFAPSDSSW WNAGAVTPGL TYGRSYPFVT MDYSSGQLDE MENRPFSTSS
LFGDRTSLPN RHGNRSGPLR TIRSKPSFYT LRGSMSEHGG LLPRRIWSDS NWV
//
