ID A0A1U8N5C8_GOSHI Unreviewed; 739 AA.
AC A0A1U8N5C8;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=RING-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012483};
DE EC=2.3.2.27 {ECO:0000256|ARBA:ARBA00012483};
GN Name=LOC107944868 {ECO:0000313|RefSeq:XP_016734185.1};
OS Gossypium hirsutum (Upland cotton) (Gossypium mexicanum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX NCBI_TaxID=3635 {ECO:0000313|Proteomes:UP000189702, ECO:0000313|RefSeq:XP_016734185.1};
RN [1] {ECO:0000313|Proteomes:UP000189702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TM-1 {ECO:0000313|Proteomes:UP000189702};
RX PubMed=25893780; DOI=10.1038/nbt.3208;
RA Li F., Fan G., Lu C., Xiao G., Zou C., Kohel R.J., Ma Z., Shang H., Ma X.,
RA Wu J., Liang X., Huang G., Percy R.G., Liu K., Yang W., Chen W., Du X.,
RA Shi C., Yuan Y., Ye W., Liu X., Zhang X., Liu W., Wei H., Wei S., Huang G.,
RA Zhang X., Zhu S., Zhang H., Sun F., Wang X., Liang J., Wang J., He Q.,
RA Huang L., Wang J., Cui J., Song G., Wang K., Xu X., Yu J.Z., Zhu Y., Yu S.;
RT "Genome sequence of cultivated Upland cotton (Gossypium hirsutum TM-1)
RT provides insights into genome evolution.";
RL Nat. Biotechnol. 33:524-530(2015).
RN [2] {ECO:0000313|RefSeq:XP_016734185.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_016734185.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Functions as an E3 ubiquitin ligase.
CC {ECO:0000256|ARBA:ARBA00003861}.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR RefSeq; XP_016734185.1; XM_016878696.1.
DR AlphaFoldDB; A0A1U8N5C8; -.
DR STRING; 3635.A0A1U8N5C8; -.
DR PaxDb; 3635-A0A1U8N5C8; -.
DR GeneID; 107944868; -.
DR KEGG; ghi:107944868; -.
DR OrthoDB; 37517at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000189702; Chromosome 5.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd16655; RING-Ubox_WDSUB1-like; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR003613; Ubox_domain.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45647; OS02G0152300 PROTEIN; 1.
DR PANTHER; PTHR45647:SF22; U-BOX DOMAIN-CONTAINING PROTEIN 32; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR Pfam; PF04564; U-box; 1.
DR SMART; SM00504; Ubox; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS51698; U_BOX; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Reference proteome {ECO:0000313|Proteomes:UP000189702};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 392..651
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 668..739
FT /note="U-box"
FT /evidence="ECO:0000259|PROSITE:PS51698"
FT COILED 267..308
FT /evidence="ECO:0000256|SAM:Coils"
FT BINDING 419
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 739 AA; 83702 MW; 4BEF83CA3C442674 CRC64;
MEGSANVLAL TDGKLARGKL KQHAVEAFQK LERQRLQERL DEYLLILDHS GVQADALWIE
MDSVEKGILE IIARHNIRWL VMGAAADKYY SKKLVELKSK KATFVCQNAA VSCHIWFACK
GRLIYTRVGR QDGSSREIAT PSPPMDSPLI TEQAVMLSES VLRERSPEPQ EDANVVRGNL
RPISLRSVHP NLPSNGVVDT YGSIMLQMDE EEHQGQASNE TDQQLEVSTI DDHNLKQEVF
AETMKRWKEE NDAIEAACKA KALESLCVKE MSRRKEMEEL LEREKQEVQK MKDQHDEFIK
DLQMVKDQKT ILESQIVESQ CVVEGLEEKM FSAVELLISF KKKRDDLRIE HENAIRVLKN
LRKLVNGGDS SFPGSQILEF SFIEINNATR DFDPSWKIGE GKYGSVYKGL LRHMNVAIKM
LPSYGSQSLL EFENEVEILS RIRHPNLVTI IGTCPESRSL VFEYLRNGSL EERLACKNKS
PPLPWQTRIR IASEICSALI FLHSNKPCIP HGNLKPSKVL LDSNFVSKLI DSGIYRLIPQ
GKSTDTSALS SVYMDPVYLE NGEVTRESDV YSFGMILLRL LTGRSALGIL NDVKCSIETE
NFNMVLDRTA GNWPLEEAQL LAHLAIRCCD TQPLDRPDFV SEIWSVLGPM RDSCVNSASC
LEAKELRCAP SHFVCPIFQE VMKDPIIAAD GFTYEADAIR GWLDSGHDRS PMTNLKLEHC
NLVPNYALLQ AIQEWQQQY
//
