ID A0A1U8NED2_GOSHI Unreviewed; 1843 AA.
AC A0A1U8NED2;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Guanine nucleotide exchange factor SPIKE 1-like {ECO:0000313|RefSeq:XP_016736313.1, ECO:0000313|RefSeq:XP_016736314.1};
GN Name=LOC107946479 {ECO:0000313|RefSeq:XP_016736313.1,
GN ECO:0000313|RefSeq:XP_016736314.1};
OS Gossypium hirsutum (Upland cotton) (Gossypium mexicanum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX NCBI_TaxID=3635 {ECO:0000313|Proteomes:UP000189702, ECO:0000313|RefSeq:XP_016736313.1};
RN [1] {ECO:0000313|Proteomes:UP000189702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TM-1 {ECO:0000313|Proteomes:UP000189702};
RX PubMed=25893780; DOI=10.1038/nbt.3208;
RA Li F., Fan G., Lu C., Xiao G., Zou C., Kohel R.J., Ma Z., Shang H., Ma X.,
RA Wu J., Liang X., Huang G., Percy R.G., Liu K., Yang W., Chen W., Du X.,
RA Shi C., Yuan Y., Ye W., Liu X., Zhang X., Liu W., Wei H., Wei S., Huang G.,
RA Zhang X., Zhu S., Zhang H., Sun F., Wang X., Liang J., Wang J., He Q.,
RA Huang L., Wang J., Cui J., Song G., Wang K., Xu X., Yu J.Z., Zhu Y., Yu S.;
RT "Genome sequence of cultivated Upland cotton (Gossypium hirsutum TM-1)
RT provides insights into genome evolution.";
RL Nat. Biotechnol. 33:524-530(2015).
RN [2] {ECO:0000313|RefSeq:XP_016736313.1, ECO:0000313|RefSeq:XP_016736314.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_016736313.1,
RC ECO:0000313|RefSeq:XP_016736314.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
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DR RefSeq; XP_016736313.1; XM_016880824.1.
DR RefSeq; XP_016736314.1; XM_016880825.1.
DR STRING; 3635.A0A1U8NED2; -.
DR PaxDb; 3635-A0A1U8NED2; -.
DR Proteomes; UP000189702; Chromosome 5.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IBA:GO_Central.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08679; C2_DOCK180_related; 1.
DR CDD; cd11684; DHR2_DOCK; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR PANTHER; PTHR23317; DEDICATOR OF CYTOKINESIS DOCK; 1.
DR PANTHER; PTHR23317:SF76; LD20667P; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000189702}.
FT DOMAIN 476..635
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1392..1841
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
SQ SEQUENCE 1843 AA; 207638 MW; 32013FE6C97C4EBB CRC64;
MDGNVATNGN GGGGYRFRRI PRHSLAHLKL DPLLDDNLEQ WPHLTELIQC YKSDWIKDDN
KYGHYESISP DSFQNQIFEG PDTDIETEMQ LASARQIKAE DANDDDLPSS SGRQFPNSNV
TKHFGQSPLL AYEAAFDWGN ERSMIFGQRI PETPTTHYGS GLKISVKVLS LSFQAGIVEP
FYGTMCIYNR ERREKLSEDF YFSVLPSEMQ DAKVPLEPRG IFYLDAPSAS ICLLIQLEKP
ATEEGGVTPS VYSRKEPVHL TERERQKLQV WSRLMPYRES FAWAIVPLFD NSIAAASGGS
ASPSSPLAPS MSGSSSHEGV FEPIAKVTSD GKLGCASGSS VIVEISNLKK VKESYTEESL
QDPKRKVHKP VKGVLKLEIE KHQTALAELD NISEGGSATN DSLDPGEAVA DLMFSRSPGN
GLDGPQTSNS KWIAIDGKEV SGNGSNSHGN LDLCADDFQA FDFRTTMRNE PFLQLFHCLY
VYPLTVNLSR KRNLFIQVEL RKDDADARRQ PLEAIHPRDR GSSLQKYAHT QVAVGARVAC
YHDEIKVSLP AVWTPSHHLL FTFFHVDLQT KLEAPKPVVI GYAALPLSTH AQLRSEISLP
IIRELVPHYL LDSGKERLDY LEDGKNVFKL RLRLCSSLYP INERIRDFFL EYDRHTLRTS
PPWGSELLEA INSLKNVDST ALLQFLHPIL NMLLHLIGNG GETLQVAAFR AMVNILTRVQ
QESVDDSERN RSLVNYVDYA FDDFGGRQPP VYPGLSTVWG SLARSKAKGY RVGPVYDDVL
AMAWFFLELI VKSMALEQTR LFYHSLPLDE DVPPMQLKEG VFRCIIQLYD CLLTEVHERC
KKGLSLAKRL NSSLAFFCYD LLSIIEPRQV FELVSLYLDK FSGVCQSVLH DCKLIFLQII
CDHDLFVEMP GRDPSDRNYL SSVLIQELFF TWDHDDLSQR AKAARILVVV LCKHEFDARY
QKPEDKLYIA QLYFPLIGQI LDEMPVFYNL NAAEKREVLI VILQIVRNLD DASAVKAWQQ
SIARTRLFFK LLEECLVHFE HRKPADGMLI GSSSRHPVGD APTSPKYSDK LSPAINNYLS
EASRQEVRPQ GTPENGYLWQ RVNSQLSSPS QPYSLREALA QAQSSRIGAS AQALRESLHP
ILRQKLELWE ENLSAAVSLQ VLEISEKFSA MAASHSIATD YGKLDCLSSI IMSFFSRNQP
LVFWKAFLPV FNNVFDLHGA TLMARENDRF LKQVAFHLLR LAVFRNDNIR KRAVIGLQIL
VRSSFYFMQT ARLRVMLTIT LSELMSDMQV TQMKSDGTLE ESGEARRLRK SLEEMADEVK
SSGLLKECGL PEDALLVTPE NFKENRWSWS DVKSLSGSLL LALDASLEHA LLGSVMSMDR
YAAAESFYKL AMAFAPVPDL HIMWLLHLCD AHQEMQSWAE AAQCAVAVAG VVMQALVARN
DGVWSKDHVT ALRKICPMVS SEITSEASAA EVEGYGASKL TVDSAVKYLQ LANKLFSQAE
LYHFCASILE LVIPVYKSRR AYGQLAKCHT LLTNIYESIL EQESSPIPFT DATYYRVGFY
GERFGKLDRK EYVYREPRDV RLGDIMEKLS HIYESRMDGN HTLHIIPDSR QVKAEELQPG
VCYLQITAVD PVMEDEDLGS RRERIFSLST GTVRARVFDR FLFDTPFTKN GKTQGGLEDQ
WKRRTVLQTE GSFPALVNRL LVIKSESLEF SPVENAIGMI ETRTAALRNE LEEPRSSEGD
QLPRLQSLQR ILQGSVAVQV NSGVLSVCTA FLSGEPATRL RSQELQQLIA ALLEFMAVCK
RAIRVHFRLI GEEDQDFHTQ LVNGFQSLTA ELSHYIPAIL SEL
//
