ID A0A1U8NG37_GOSHI Unreviewed; 742 AA.
AC A0A1U8NG37;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE RecName: Full=apyrase {ECO:0000256|ARBA:ARBA00012148};
DE EC=3.6.1.5 {ECO:0000256|ARBA:ARBA00012148};
DE AltName: Full=ATP-diphosphatase {ECO:0000256|ARBA:ARBA00031428};
DE AltName: Full=ATP-diphosphohydrolase {ECO:0000256|ARBA:ARBA00032306};
DE AltName: Full=Adenosine diphosphatase {ECO:0000256|ARBA:ARBA00030084};
DE AltName: Full=NTPDase {ECO:0000256|ARBA:ARBA00031370};
GN Name=LOC107946821 {ECO:0000313|RefSeq:XP_016736774.1,
GN ECO:0000313|RefSeq:XP_016736775.1, ECO:0000313|RefSeq:XP_016736776.1};
OS Gossypium hirsutum (Upland cotton) (Gossypium mexicanum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX NCBI_TaxID=3635 {ECO:0000313|Proteomes:UP000189702, ECO:0000313|RefSeq:XP_016736774.1};
RN [1] {ECO:0000313|Proteomes:UP000189702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TM-1 {ECO:0000313|Proteomes:UP000189702};
RX PubMed=25893780; DOI=10.1038/nbt.3208;
RA Li F., Fan G., Lu C., Xiao G., Zou C., Kohel R.J., Ma Z., Shang H., Ma X.,
RA Wu J., Liang X., Huang G., Percy R.G., Liu K., Yang W., Chen W., Du X.,
RA Shi C., Yuan Y., Ye W., Liu X., Zhang X., Liu W., Wei H., Wei S., Huang G.,
RA Zhang X., Zhu S., Zhang H., Sun F., Wang X., Liang J., Wang J., He Q.,
RA Huang L., Wang J., Cui J., Song G., Wang K., Xu X., Yu J.Z., Zhu Y., Yu S.;
RT "Genome sequence of cultivated Upland cotton (Gossypium hirsutum TM-1)
RT provides insights into genome evolution.";
RL Nat. Biotechnol. 33:524-530(2015).
RN [2] {ECO:0000313|RefSeq:XP_016736774.1, ECO:0000313|RefSeq:XP_016736775.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_016736774.1,
RC ECO:0000313|RefSeq:XP_016736775.1};
RG RefSeq;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ribonucleoside 5'-triphosphate + 2 H2O = a ribonucleoside
CC 5'-phosphate + 2 H(+) + 2 phosphate; Xref=Rhea:RHEA:36795,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:58043, ChEBI:CHEBI:61557; EC=3.6.1.5;
CC Evidence={ECO:0000256|ARBA:ARBA00000211};
CC -!- SIMILARITY: Belongs to the GDA1/CD39 NTPase family.
CC {ECO:0000256|ARBA:ARBA00009283}.
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DR RefSeq; XP_016736774.1; XM_016881285.1.
DR RefSeq; XP_016736775.1; XM_016881286.1.
DR RefSeq; XP_016736776.1; XM_016881287.1.
DR STRING; 3635.A0A1U8NG37; -.
DR PaxDb; 3635-A0A1U8NG37; -.
DR GeneID; 107946821; -.
DR KEGG; ghi:107946821; -.
DR OrthoDB; 1222189at2759; -.
DR Proteomes; UP000189702; Chromosome 5.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0017110; F:nucleoside diphosphate phosphatase activity; IBA:GO_Central.
DR GO; GO:0009134; P:nucleoside diphosphate catabolic process; IBA:GO_Central.
DR Gene3D; 3.30.420.40; -; 1.
DR Gene3D; 3.30.420.150; Exopolyphosphatase. Domain 2; 1.
DR InterPro; IPR000407; GDA1_CD39_NTPase.
DR PANTHER; PTHR11782; ADENOSINE/GUANOSINE DIPHOSPHATASE; 1.
DR PANTHER; PTHR11782:SF125; APYRASE 7-RELATED; 1.
DR Pfam; PF01150; GDA1_CD39; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000189702};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 94..116
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 580..600
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 716..742
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 726..742
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 268
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR600407-1"
FT BINDING 299..303
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR600407-2"
SQ SEQUENCE 742 AA; 82173 MW; 38B329FC2BBE7D06 CRC64;
MSPTLSPQPD KNLPHGFGFA NSGIKNNLRL SASLQDFSSY RRLDPEAANL ISEIDKSMSY
SKPPLQRENA AASFSKEKGL PSGTPFLMRK WVRLIMALLC LVLLIFLTYM VCMFIYSNWS
RGASKFYVVL DCGSTGTRVY VYKASIGHKN DGSLPIVMKS LTEGLSRKPS TQSGRAYDRM
ETEPGLHKLV HNKSGLAAAL NPLISWAEKQ IPEREHKNTF LFLYATAGVR RLPNADSKWL
LENAWSILKR SPFLCHKEWV KIITGTEEAY LGWTALNYLT SMLGATLKKA TFGALDLGGS
SLQVTFENEH RQHNETNLNL KIGAVTHHLS AYSLSGYGLN DAFDKSVVRL LRSLPDGSNA
NLVNGMIEIK HPCLHSGYKE RYICSQCASK DQESGSPLVQ GKILDKGGKS GIPVHLTGAP
NWEQCSAIAK AAVNLSEWST LYPGIDCDLQ PCALPDSLPR PYGQFYALSG FFVVYRFFNL
SPEAALDDVL EKGREFCEKP WEVAKKSVAP QPFIEQYCFR APYIVSLLRE GLHISDSQLV
VGSGSITWTM GVALLEAGKS FSSRLALPGY QILQAKIDPM ILIAILLMSL VLLVCALSCV
SNWMPRFFRR SYLPLFRHNS ASTSVLNIPS PFRLKRWSPM NTGDGRVKMP LSPTVHGSQQ
TPFGLGHSLG SSIQLTESSL YPSTSSVSHS YSSSSLGQMQ FDNSSVGSFW SPHRSQMRLQ
SRRSQSREDL NSSLAETQMV KV
//