ID A0A1U8NMX0_GOSHI Unreviewed; 1142 AA.
AC A0A1U8NMX0;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Disease resistance protein ADR2-like {ECO:0000313|RefSeq:XP_016722966.1, ECO:0000313|RefSeq:XP_016740220.1};
GN Name=LOC107949979 {ECO:0000313|RefSeq:XP_016740220.1};
GN Synonyms=LOC107934949 {ECO:0000313|RefSeq:XP_016722966.1};
OS Gossypium hirsutum (Upland cotton) (Gossypium mexicanum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX NCBI_TaxID=3635 {ECO:0000313|Proteomes:UP000189702, ECO:0000313|RefSeq:XP_016740220.1};
RN [1] {ECO:0000313|Proteomes:UP000189702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TM-1 {ECO:0000313|Proteomes:UP000189702};
RX PubMed=25893780; DOI=10.1038/nbt.3208;
RA Li F., Fan G., Lu C., Xiao G., Zou C., Kohel R.J., Ma Z., Shang H., Ma X.,
RA Wu J., Liang X., Huang G., Percy R.G., Liu K., Yang W., Chen W., Du X.,
RA Shi C., Yuan Y., Ye W., Liu X., Zhang X., Liu W., Wei H., Wei S., Huang G.,
RA Zhang X., Zhu S., Zhang H., Sun F., Wang X., Liang J., Wang J., He Q.,
RA Huang L., Wang J., Cui J., Song G., Wang K., Xu X., Yu J.Z., Zhu Y., Yu S.;
RT "Genome sequence of cultivated Upland cotton (Gossypium hirsutum TM-1)
RT provides insights into genome evolution.";
RL Nat. Biotechnol. 33:524-530(2015).
RN [2] {ECO:0000313|RefSeq:XP_016722966.1, ECO:0000313|RefSeq:XP_016740220.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_016722966.1,
RC ECO:0000313|RefSeq:XP_016740220.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_016722966.1; XM_016867477.1.
DR RefSeq; XP_016740220.1; XM_016884731.1.
DR PaxDb; 3635-A0A1U8NMX0; -.
DR GeneID; 107949979; -.
DR KEGG; ghi:107949979; -.
DR OrthoDB; 5477528at2759; -.
DR Proteomes; UP000189702; Chromosome 7.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11017:SF580; DISEASE RESISTANCE-LIKE PROTEIN DSC1; 1.
DR PANTHER; PTHR11017; LEUCINE-RICH REPEAT-CONTAINING PROTEIN; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51450; LRR; 1.
DR PROSITE; PS50104; TIR; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000189702}.
FT DOMAIN 11..178
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT REGION 1119..1142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1142 AA; 129812 MW; FF89357799507092 CRC64;
MASSSPSSRQ TKHQVFLSFR GEDTRLNFTS HLLKALKDTG LNVFFDEETL ERGEQISPAL
SNAIMASNLS IIILSKDYAS SKSCLAEISC IMDCKHTRRQ IVLPIFYHVD PFDVRNLGGS
FKTSFSDHES KSLDQVRRWK KAFADVGKLK GWHIEGGKFD RPETKYIKDI VEYVTKKLMN
NKSSTAFEEL VGIDYQKKTI LKLINQKDCR VIGLWGMAGI GKTTLANVVY HEICSKFKSC
WFLQNVREKI RQQGMESLRN NFVSKILNQQ IDILTPSIGS AFIRERLNNK KVIVVVDDVD
DPDLIDYLGV KHFGDGSKII LISRDRQVLK NGGADKIHKV NRLNEKSSLQ LFSTFAFKQL
NPTANFRDLS NQFVRYAQGN PLALKVLGCK LYTKSRKEWE SEVDRLKEYG QPKISQILKS
SFDELDELEK NLFLDIACFF KGKYKEEVED ILCSLYNGAV CGISNLVDKC LLDIIHFQDM
LEEDLRLFRP TFAAERVVDF STACAAGPLI ISMHDILEEM GKDIIRQEAI GIGNCSRLWS
PNNVHQMLRY NKGNEAIKGI KLDMSQIDNL KLSPTVFENM LNLRFIHFYF PRKFGECWNN
KLLADQVDIV SLPDELRYLC WECYPFKSLS SSFNPKNLVV LKLPHGDMEQ LWNGDNHQDL
VSLKEIDLFD CKNLRKIPSL LGAINLKSLC CRGCESLVEL PCLTHLASLK SFDLHGCHNL
KKIPEIPSHF HYLDLEGTGI EEVPDSIEHL IWLRQLRLSN SRVKNVSNNI LKLESLNDLD
LSHCPISKFP EIPKSLRRLN LSKTQIEQVS LSFDYIGILA DLDMSGSSIQ KLQCYISLSG
SRKIPTIDVP SSILSFKSLR NLRMNHCKSL KLLLDLPPYL WRLDAHDCPS LEKVSFIQQH
GFLGGAYELS MMFSNCSNLN QDSIDSIEAN AMFKIGSIAE KWRGQNIFFP RASVCCFPGT
EISANKFESQ NVYSSLTLKI APNVCGKRRF LAFAICLVAD LTHCSGFKEL ELTCEYQLTV
SSCSDGGGGY EKFKSVLYDG GSLKSEWNCM GDHVLILFQK DMIKEDKNYE EATFEFYIRS
YSYNEEGEKI CLHDFKVKKC GVHVFYVDAK SDADATEKRV AGNKRSFSHD GEEGDGGLKR
LN
//
