ID A0A1U8NVQ2_GOSHI Unreviewed; 1915 AA.
AC A0A1U8NVQ2;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Histone-lysine N-methyltransferase ASHH2-like isoform X3 {ECO:0000313|RefSeq:XP_016742054.1};
GN Name=LOC107951494 {ECO:0000313|RefSeq:XP_016742054.1};
OS Gossypium hirsutum (Upland cotton) (Gossypium mexicanum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX NCBI_TaxID=3635 {ECO:0000313|Proteomes:UP000189702, ECO:0000313|RefSeq:XP_016742054.1};
RN [1] {ECO:0000313|Proteomes:UP000189702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TM-1 {ECO:0000313|Proteomes:UP000189702};
RX PubMed=25893780; DOI=10.1038/nbt.3208;
RA Li F., Fan G., Lu C., Xiao G., Zou C., Kohel R.J., Ma Z., Shang H., Ma X.,
RA Wu J., Liang X., Huang G., Percy R.G., Liu K., Yang W., Chen W., Du X.,
RA Shi C., Yuan Y., Ye W., Liu X., Zhang X., Liu W., Wei H., Wei S., Huang G.,
RA Zhang X., Zhu S., Zhang H., Sun F., Wang X., Liang J., Wang J., He Q.,
RA Huang L., Wang J., Cui J., Song G., Wang K., Xu X., Yu J.Z., Zhu Y., Yu S.;
RT "Genome sequence of cultivated Upland cotton (Gossypium hirsutum TM-1)
RT provides insights into genome evolution.";
RL Nat. Biotechnol. 33:524-530(2015).
RN [2] {ECO:0000313|RefSeq:XP_016742054.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_016742054.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR RefSeq; XP_016742054.1; XM_016886565.1.
DR OrthoDB; 54704at2759; -.
DR Proteomes; UP000189702; Chromosome 8.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046975; F:histone H3K36 methyltransferase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd19172; SET_SETD2; 1.
DR Gene3D; 3.30.40.100; -; 1.
DR Gene3D; 2.170.270.10; SET domain; 1.
DR InterPro; IPR006560; AWS_dom.
DR InterPro; IPR003616; Post-SET_dom.
DR InterPro; IPR001214; SET_dom.
DR InterPro; IPR046341; SET_dom_sf.
DR InterPro; IPR044437; SETD2/Set2_SET.
DR InterPro; IPR011124; Znf_CW.
DR PANTHER; PTHR22884:SF413; HISTONE-LYSINE N-METHYLTRANSFERASE CG1716-RELATED; 1.
DR PANTHER; PTHR22884; SET DOMAIN PROTEINS; 1.
DR Pfam; PF17907; AWS; 1.
DR Pfam; PF00856; SET; 1.
DR Pfam; PF07496; zf-CW; 1.
DR SMART; SM00570; AWS; 1.
DR SMART; SM00508; PostSET; 1.
DR SMART; SM00317; SET; 1.
DR SUPFAM; SSF82199; SET domain; 1.
DR PROSITE; PS51215; AWS; 1.
DR PROSITE; PS50868; POST_SET; 1.
DR PROSITE; PS50280; SET; 1.
DR PROSITE; PS51050; ZF_CW; 1.
PE 4: Predicted;
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000189702};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 1274..1327
FT /note="CW-type"
FT /evidence="ECO:0000259|PROSITE:PS51050"
FT DOMAIN 1388..1438
FT /note="AWS"
FT /evidence="ECO:0000259|PROSITE:PS51215"
FT DOMAIN 1432..1557
FT /note="SET"
FT /evidence="ECO:0000259|PROSITE:PS50280"
FT DOMAIN 1565..1581
FT /note="Post-SET"
FT /evidence="ECO:0000259|PROSITE:PS50868"
FT REGION 311..343
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 589..614
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 770..804
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 851..887
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1057..1128
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1143..1226
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1643..1665
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1732..1780
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1072..1086
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1104..1126
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1151..1178
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1182..1223
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1732..1750
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1751..1780
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1915 AA; 207379 MW; 594FDF09DA267AD2 CRC64;
MGSCGNMTFV NEPSREVAAA AAAEQHLCSE SMGKLVSEQR DCVVIDSNGD CASEPGEDEN
SVCKRSGDID CKVGIKGEAQ IVGSGMKGLM GGECCENSVC LKKNGGEIAD ASCSKALVGD
MCGDSVVCLE NNQGELMGDS GLKELMGNAN DDTVVCLKDQ GESMNDSDSK ELTDDRCRDC
IVYSIENQGE KVDGSFPLDL RSDTYRDSTV CSIGNLGENV DGAGSKELMG DICGDAIVCL
NGNQGENPDC SGPEELMGYV DNTGYSNEIQ CENVDSCLNE LKGDRIGDHG VGLNENQDDV
DIHDSVTDVC LEKSGSSGED GTNATKGSLG LSQDKNSASL SSGMEISTNC KDQMKGDNEN
VVGLMLKECM GNNQGRICLT ENMGIDGHLD SENNVSRDGE MPIELNTIST SPRSSVKLDK
QDDDERVNGS ILQRIVEYGE KKFEEKNDAV ERKGTDVLNQ ILLSENFKWP FELIDATGEH
KSKDGTSTYC SSSEVAMEEK QEVLTEVEAN ICNQMSFIQG SHLASTSIGI GDCRSDCPRQ
IDLKDGKAIV GPSLDGESGA SPMIESETCG KISTSCCVET ISNLQQTGDS VGSCDGHNQK
DDPSSSGLSL ESFTKPVETK SNDDLCIELL ASRRLSDTRK NAQTVGNDIS DSSGDGVTEV
SEGRTDFLAY TKAETSCEII INAKGKACNS NRDSFEQGAN CLCDKSTSLS CQPVDVVDNG
LSGRLDPQDL LAKDVCAAIS SSSSIDCSGQ RENEGKDIVK ADCVLETKNC PTTSSSSRKG
RQKSKSSRKT PAKRGTRNCS STKLRRPHGS IEFLFKATRR KRSCSSKPAR SSIWGLLSNI
AKFIEPCPDP SCNGVQNRKP SKARGGRGSG KRSKNRAGQN RKESSGLSNT LTSCLRLKIK
VGKEVAPSNV NTLVAEVVGP SVLIGTSFSN YGKETDLQYP TVANIVEDKV EAGSEMQFQS
KEDQEMVKTC SDVFLTEVKL ANKAVRCSEN LERMSEDATD SSLISQSDAV AEASQEAIEN
KCMDPGTSPD SEVINTIPDA QIGLTHQEES LDTVLNTSGA LASPRGAKTS KGSNRGKKDN
HRSPGAASTR KAKSSKSRRS REKTTGNGLV SSEALTSSSA ANSSRENWIG VPKEATEMEN
SMDINDCCSP DVPDTKNTKH FSSSKSKRNQ LSKSSRSHGA NKGKSRVSDS VKSRKGNGSK
RRGDESKSVS KSKVKEKCSN EEIVARGGKS PVTVGAAGNQ ISDDNEHLNT GNSIESANMV
NVGLVPDGVM EQHTQPDNAW VRCDDCHKWR RIPVSLVKSI DEAYHWVCGD NVDKAFADCS
IPQEKSNADI NAELGISDAE EDGCDGFNYK ELDKGFETKR MTVSPPSHFW RIDSNQFLHR
GRKTQTIDEI MVCQCKRPPD GKLGCGDECL NRMLNIECVQ GTCPCGDLCS NQQFQNRKYA
MMKWDRFGKK GFGLRMLENI SAGHFLIEYV GEVLDMQAYE ARQKEYASRG QRHFYFMTLN
GSEVIDAYVK GNLGRFINHS CDPNCRTEKW MVNGEICIGL FALRDIKKGE EVTFDYNYVR
VFGAAAKKCH CGSPHCRGYI GGDPLSAEVI VHDDSDEESP EPTMLEDGET WTGFKYVISR
SSSSDGAAMQ SVESVITDGV LKPENMPEAE DSVNRSASAT SELKTVETED LKGNLQLVIQ
PEEVLPVTIA SESVQPDGTE EQKAMNKTSC SIQKLDASQD MSDNRLSSDV IDANKKSKSD
AAEDKQVSAK SHPLMKTSRS SSSIKKGKIS SNSLSGNKVQ TTSNKFQVST VKPRKFSENS
STCRFEAVEE KLNELLDSEG GITKRKDASK GYLKLLLLTA TSGDSGSGEA IQSNRELSMI
LDALLKTKSG HVLTDIINKN GLQMLHNIMK KYRKDFKKIP ILRKLLKFAT YFCRF
//
