ID A0A1U8P6W4_GOSHI Unreviewed; 1304 AA.
AC A0A1U8P6W4;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase {ECO:0000256|ARBA:ARBA00011982};
DE EC=3.2.2.6 {ECO:0000256|ARBA:ARBA00011982};
GN Name=LOC107955672 {ECO:0000313|RefSeq:XP_016746966.1,
GN ECO:0000313|RefSeq:XP_016746967.1};
OS Gossypium hirsutum (Upland cotton) (Gossypium mexicanum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX NCBI_TaxID=3635 {ECO:0000313|Proteomes:UP000189702, ECO:0000313|RefSeq:XP_016746967.1};
RN [1] {ECO:0000313|Proteomes:UP000189702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TM-1 {ECO:0000313|Proteomes:UP000189702};
RX PubMed=25893780; DOI=10.1038/nbt.3208;
RA Li F., Fan G., Lu C., Xiao G., Zou C., Kohel R.J., Ma Z., Shang H., Ma X.,
RA Wu J., Liang X., Huang G., Percy R.G., Liu K., Yang W., Chen W., Du X.,
RA Shi C., Yuan Y., Ye W., Liu X., Zhang X., Liu W., Wei H., Wei S., Huang G.,
RA Zhang X., Zhu S., Zhang H., Sun F., Wang X., Liang J., Wang J., He Q.,
RA Huang L., Wang J., Cui J., Song G., Wang K., Xu X., Yu J.Z., Zhu Y., Yu S.;
RT "Genome sequence of cultivated Upland cotton (Gossypium hirsutum TM-1)
RT provides insights into genome evolution.";
RL Nat. Biotechnol. 33:524-530(2015).
RN [2] {ECO:0000313|RefSeq:XP_016746966.1, ECO:0000313|RefSeq:XP_016746967.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_016746966.1,
RC ECO:0000313|RefSeq:XP_016746967.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide;
CC Xref=Rhea:RHEA:16301, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:57967; EC=3.2.2.6;
CC Evidence={ECO:0000256|ARBA:ARBA00000404};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16302;
CC Evidence={ECO:0000256|ARBA:ARBA00000404};
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DR RefSeq; XP_016746966.1; XM_016891477.1.
DR RefSeq; XP_016746967.1; XM_016891478.1.
DR PaxDb; 3635-A0A1U8P6W4; -.
DR GeneID; 107955672; -.
DR KEGG; ghi:107955672; -.
DR OrthoDB; 1094284at2759; -.
DR Proteomes; UP000189702; Chromosome 9.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR045344; C-JID.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR011713; Leu-rich_rpt_3.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR11017:SF559; DISEASE RESISTANCE PROTEIN (TIR-NBS-LRR CLASS) FAMILY; 1.
DR PANTHER; PTHR11017; LEUCINE-RICH REPEAT-CONTAINING PROTEIN; 1.
DR Pfam; PF20160; C-JID; 1.
DR Pfam; PF07725; LRR_3; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS50104; TIR; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000189702}.
FT DOMAIN 15..181
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 1304 AA; 147840 MW; 7F935124EC17706C CRC64;
MSSLLPTSSS IPRQKEYDVF LSFRGEDTRH NFTDHLNDAL RRSGIVTFRD DPKLEAGEEI
APELFKAIQQ SWCSVIVISE NYVFSGWCLE ELAEIVKQKK ETGHKVFPIF YGVDPSDLRQ
QKGKAETAFA KHEERYKENE AKIQRWRNAL TEVANIKGWH SNNRHESEFI GDIVKKISAK
LCQTYPIDYD ELVGISPSLD ELHSEIEIGE DDIRIIGICG MGGIGKTTLA RVVYSQMSPH
FEGKSFLADV REVSEKCGLV SLQKQLLSQI LFDESFNFFN VHEGKAIISH RLPHKRVLVV
LDDVDNLQHL KCLVGRHNWF GVGSRIIVTT RDEHLLRSYQ VDGVYKPTTL KANDALHLFN
LKAFGCKIVP KEDFIELAKH VVGYAGGLPL ALEVLGSFLC DRDARQWTSA IERLERDSNK
EILDRLQISF DGLEEREKDI FLDIACFFNG EEKDFIMKVM DGCEFFPDIG IDVLIKKSLL
TVNKYNQLRM HDLLQEMGRK IVREKSVDEP RKRCRLWVEK DVYHVLKTQT ATKMIEGIII
GNEREMSETL TLSRDAFLKM KRLRLLKILC RSNCCDLTYL SNELRLLDWM GCPLRSLPSS
FKPENLVILL LPYSNIEQLW KENVLLYKLK VLNLEGSENL IKAPDFTTTP NLEILDLEGC
TRLVYVHPSV GVLTRLKLLN LRGCKSLRSF PTKIGMLSLE KLILSGCSKL QSFPEIDGKM
ECLLELCFDG TNIKELPSSM GNLGRLKVLN LKDSKSLGSL PIKIGMESLE KLILSGCSNL
KRFPEIDGKM ECLLELYLDG SGIKELPISI GNLSSLVLLN LKDCRNLVDL PGSIGGCKSL
KSLNLSGCYK VEYLPENLQQ IEFLEELDLS ETSMTKPPLF IFQFKNLKVL SFNGSKGSSS
KLQKKLPSLL KVIQRGRTNS MALMLPSLSG LSSLKELNLR DRNLCEGDIP SDISRLSSLR
HLDLGGNNFI SIPSCVTRIS KLDFLRLSDC RALKSLPELP TSIGGVRING CPSLEIVANP
SKVCNSSYYS DIVGVNCFRL AENIDALTLL KKHLKVFGNS RKIFDIIIPG SEMPEWFSQQ
RGESWIKIDL PLEVRNDSQW MGVALCCIFV SDDASRDENL MCSAVIHGGY SRQVNCTLSN
FQGRNPLPVG SSGWNVNFHF EQPVMKDHIL IRYFSRDKLY PVSLEENFGE RETNNLWTTD
CLDQECHQLD LSFTDPFHNS VKVKKCGVRI VYERDLEETQ VLHSSQCCAN FEDIQQHSAD
DGSIGKGSLI KRKRNMYEEM DEGPQPKRMQ KIFSSIMGRL GKKH
//
