ID A0A1U8PC54_GOSHI Unreviewed; 487 AA.
AC A0A1U8PC54;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=2-oxoisovalerate dehydrogenase subunit alpha 1, mitochondrial-like {ECO:0000313|RefSeq:XP_016748766.1};
GN Name=LOC107957713 {ECO:0000313|RefSeq:XP_016748766.1};
OS Gossypium hirsutum (Upland cotton) (Gossypium mexicanum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX NCBI_TaxID=3635 {ECO:0000313|Proteomes:UP000189702, ECO:0000313|RefSeq:XP_016748766.1};
RN [1] {ECO:0000313|Proteomes:UP000189702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TM-1 {ECO:0000313|Proteomes:UP000189702};
RX PubMed=25893780; DOI=10.1038/nbt.3208;
RA Li F., Fan G., Lu C., Xiao G., Zou C., Kohel R.J., Ma Z., Shang H., Ma X.,
RA Wu J., Liang X., Huang G., Percy R.G., Liu K., Yang W., Chen W., Du X.,
RA Shi C., Yuan Y., Ye W., Liu X., Zhang X., Liu W., Wei H., Wei S., Huang G.,
RA Zhang X., Zhu S., Zhang H., Sun F., Wang X., Liang J., Wang J., He Q.,
RA Huang L., Wang J., Cui J., Song G., Wang K., Xu X., Yu J.Z., Zhu Y., Yu S.;
RT "Genome sequence of cultivated Upland cotton (Gossypium hirsutum TM-1)
RT provides insights into genome evolution.";
RL Nat. Biotechnol. 33:524-530(2015).
RN [2] {ECO:0000313|RefSeq:XP_016748766.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_016748766.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_016748766.1; XM_016893277.1.
DR AlphaFoldDB; A0A1U8PC54; -.
DR STRING; 3635.A0A1U8PC54; -.
DR PaxDb; 3635-A0A1U8PC54; -.
DR GeneID; 107957713; -.
DR KEGG; ghi:107957713; -.
DR OrthoDB; 952at2759; -.
DR Proteomes; UP000189702; Chromosome 10.
DR GO; GO:0005947; C:mitochondrial alpha-ketoglutarate dehydrogenase complex; IBA:GO_Central.
DR GO; GO:0016624; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor; IEA:InterPro.
DR GO; GO:0009083; P:branched-chain amino acid catabolic process; IBA:GO_Central.
DR CDD; cd02000; TPP_E1_PDC_ADC_BCADC; 1.
DR Gene3D; 3.40.50.970; -; 1.
DR InterPro; IPR001017; DH_E1.
DR InterPro; IPR029061; THDP-binding.
DR PANTHER; PTHR43380; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43380:SF1; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL; 1.
DR Pfam; PF00676; E1_dh; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000189702}.
FT DOMAIN 151..447
FT /note="Dehydrogenase E1 component"
FT /evidence="ECO:0000259|Pfam:PF00676"
FT REGION 468..487
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 487 AA; 54861 MW; 3D700EB0C7D71E8A CRC64;
MANWLRISSR TVANHIKKRM NKGFMGGAVH VNQSSGLWWG LNRGGPVSDR NGRHIDPLAW
NRATFLCVQR FKSTLAEKQH DSFLSSDSDD DNQSVDFPGG KVSYTSEMSF ISESSQTRVP
CYRVLDDDGD LISDCDFQQV SKEVAVKMYS NMVTLQIMDN IFYEAQRQGR ISFYLTSAGE
EAISIASAAA LSEQDIILPQ YREPGVLLWR GFTLQEFADQ CFGNKADYGK GRQMPIHYGS
KKHNFFTISS PIATQLPQAA GIAYSLKMDN KKACVVSYIG DGGTSEGDFH AGLNFAAVME
APVIFFCRNN GWAISTNVSE QFRSDGIVVK GRAYGIRSIR VDGNDALAVY SAVSAAREMA
INEQRPILIE ALTYRVGHHS TSDDSTKYRQ LDEIVYWKKA RNPVNRFRNW VQSIGWWSEQ
QETQLRNSVK KQLLEAIQVA EKTEKPPLSE LFTDVYDHPP SNLEEQEKHL RETVTRHPKD
YPSDISV
//
