ID A0A1U8PFM8_GOSHI Unreviewed; 783 AA.
AC A0A1U8PFM8;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=RING-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012483};
DE EC=2.3.2.27 {ECO:0000256|ARBA:ARBA00012483};
GN Name=LOC107958645 {ECO:0000313|RefSeq:XP_016749955.1};
OS Gossypium hirsutum (Upland cotton) (Gossypium mexicanum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX NCBI_TaxID=3635 {ECO:0000313|Proteomes:UP000189702, ECO:0000313|RefSeq:XP_016749955.1};
RN [1] {ECO:0000313|Proteomes:UP000189702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TM-1 {ECO:0000313|Proteomes:UP000189702};
RX PubMed=25893780; DOI=10.1038/nbt.3208;
RA Li F., Fan G., Lu C., Xiao G., Zou C., Kohel R.J., Ma Z., Shang H., Ma X.,
RA Wu J., Liang X., Huang G., Percy R.G., Liu K., Yang W., Chen W., Du X.,
RA Shi C., Yuan Y., Ye W., Liu X., Zhang X., Liu W., Wei H., Wei S., Huang G.,
RA Zhang X., Zhu S., Zhang H., Sun F., Wang X., Liang J., Wang J., He Q.,
RA Huang L., Wang J., Cui J., Song G., Wang K., Xu X., Yu J.Z., Zhu Y., Yu S.;
RT "Genome sequence of cultivated Upland cotton (Gossypium hirsutum TM-1)
RT provides insights into genome evolution.";
RL Nat. Biotechnol. 33:524-530(2015).
RN [2] {ECO:0000313|RefSeq:XP_016749955.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_016749955.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.27; Evidence={ECO:0000256|ARBA:ARBA00000900};
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR RefSeq; XP_016749955.1; XM_016894466.1.
DR AlphaFoldDB; A0A1U8PFM8; -.
DR PaxDb; 3635-A0A1U8PFM8; -.
DR GeneID; 107958645; -.
DR KEGG; ghi:107958645; -.
DR OMA; PSDETIC; -.
DR OrthoDB; 2721872at2759; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000189702; Chromosome 10.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd16664; RING-Ubox_PUB; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR045210; RING-Ubox_PUB.
DR InterPro; IPR003613; Ubox_domain.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR23315; U BOX DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR23315:SF278; U-BOX DOMAIN-CONTAINING PROTEIN 3; 1.
DR Pfam; PF00514; Arm; 4.
DR Pfam; PF04564; U-box; 1.
DR SMART; SM00185; ARM; 5.
DR SMART; SM00504; Ubox; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50176; ARM_REPEAT; 3.
DR PROSITE; PS51698; U_BOX; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000189702};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 235..309
FT /note="U-box"
FT /evidence="ECO:0000259|PROSITE:PS51698"
FT REPEAT 539..581
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 621..663
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 662..703
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
SQ SEQUENCE 783 AA; 85869 MW; 30F3EB1EAAE83A3E CRC64;
MDTTSVRCLI NSIARYVHLV SCQTRKVVPI EKDYRNMVVV LKLLKPLLDD VVDCEISSDE
ILCKECEELD MLVNEAREFM ENWCPKMSKI HMVLQSEPFL IKMQSSSLQI CHILYKSLQS
SPSTSSITSV QHCIREIKCL NQERLSENIG DALRSLKDGA IPCTDHLVKV IKSLNLTSNQ
ELLKETVAVE KERMNAQVNN VKGKLDQINQ IVDLISHIRD YMLKIEHFEP TSGILIPPHF
VCPLSFELMM DPVIVASGQT YDRASIQKWF DSGLTICPKT RQTLKHTNLT PNSTVKAMLA
NWCDKNNLQL SNHTGHAKLV SISSPSNHKS SQDLTHTDSF RCFANSSSST SRSSIEVGTG
LEKLKIDISS RYSGDCNRCQ SGEIDKYDQS SDHSYIHSRT ESAASEVSSI DYLPPALNDL
SRRLKKPEMN EVAEISTKGL GTFPIRKDSG FSSWTSGKQL QVSGTKVEEA VNGNHDYNRA
YSITFSGSGC DDLTTTSHVM ELVDNLKSLS NEVQTKAALE LRLLAKNNME NRIIIGRCGA
IAPLLCLLYS EVKLIQEHAV TALLNLSISE DNKAIIAKSG AIEPLIHVLK SGNDGAKENS
AAALFSLSAL EDYKARIGRS GAVKALVNLL GSGTLRGKKD AATALFNLSI FHENKARMVQ
AGAVKYLVLL MDPDSGMVDK AVALLSNLST VAEGRVAIVG EGGVPLLVEI LESGSQRGKE
NAASVLLQLC LNSPKFCTLV LQEGAVPPLV ALSQSGTPRA KEKAQQLLSH FRNQREGATG
KSK
//
