ID A0A1U8PIB2_GOSHI Unreviewed; 1340 AA.
AC A0A1U8PIB2;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN Name=LOC107958717 {ECO:0000313|RefSeq:XP_016750043.1};
OS Gossypium hirsutum (Upland cotton) (Gossypium mexicanum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX NCBI_TaxID=3635 {ECO:0000313|Proteomes:UP000189702, ECO:0000313|RefSeq:XP_016750043.1};
RN [1] {ECO:0000313|Proteomes:UP000189702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TM-1 {ECO:0000313|Proteomes:UP000189702};
RX PubMed=25893780; DOI=10.1038/nbt.3208;
RA Li F., Fan G., Lu C., Xiao G., Zou C., Kohel R.J., Ma Z., Shang H., Ma X.,
RA Wu J., Liang X., Huang G., Percy R.G., Liu K., Yang W., Chen W., Du X.,
RA Shi C., Yuan Y., Ye W., Liu X., Zhang X., Liu W., Wei H., Wei S., Huang G.,
RA Zhang X., Zhu S., Zhang H., Sun F., Wang X., Liang J., Wang J., He Q.,
RA Huang L., Wang J., Cui J., Song G., Wang K., Xu X., Yu J.Z., Zhu Y., Yu S.;
RT "Genome sequence of cultivated Upland cotton (Gossypium hirsutum TM-1)
RT provides insights into genome evolution.";
RL Nat. Biotechnol. 33:524-530(2015).
RN [2] {ECO:0000313|RefSeq:XP_016750043.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_016750043.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_016750043.1; XM_016894554.1.
DR GeneID; 107958717; -.
DR OrthoDB; 5477296at2759; -.
DR Proteomes; UP000189702; Chromosome 10.
DR GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0045324; P:late endosome to vacuole transport; IEA:InterPro.
DR GO; GO:0016236; P:macroautophagy; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000357; HEAT.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR045162; Vps15-like.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR17583; PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4; 1.
DR PANTHER; PTHR17583:SF0; PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4; 1.
DR Pfam; PF02985; HEAT; 1.
DR Pfam; PF00400; WD40; 3.
DR SMART; SM00320; WD40; 6.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50077; HEAT_REPEAT; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 4: Predicted;
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Reference proteome {ECO:0000313|Proteomes:UP000189702};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT REPEAT 338..370
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REPEAT 921..953
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1311..1340
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 1188..1221
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1340 AA; 149033 MW; 5B6259696771266B CRC64;
MQVAQDAPLK PSMDIFAIGC VIAELFLEGQ PLFELSQLLA YRRGQYDPSQ HLEKIPDIGV
RKMILHMIQL EPESRLSAES YLQNYVAAVF PSYFSPFLHG FYRCWNPLHS DMRIAMCQRV
FPEMLKQMMS KRSRDEMGKG LGKSHTLNGH LSQEIVAKQQ SEEIAPKQNL SSANHLLTKR
EKIDNASIRD QLKLPGNINT LLGDVEQSNH YLGEKSTRGD TPKYELSQDF KQRGMQSPAV
HQNISDLFRK NDHPFLKKIT MDDLNSLMSD YDSQSDTFGM PFLPLPQDSM KCEGMVLVAS
LLCSCIRNVK LPHLRRGAIL LLKTSSLYID DEDRLQRVLP YVIAMLSDPA AIVRCAALET
LCDILPLVRE FPPSDAKIFP EYILPMLSML PDDPEESVRI CYASNIAKLA LTAYGFLIHS
IRLSEAGVLN ETNLPQKSLA SSGESSGRIQ RSNSDAQLGQ LRKVIAEVVQ ELVMGQKQTP
NIRRALLQDI GNLCCFFGQR QSNDFLLPIL PAFLNDRDEQ LRAVFYGKIV FVCFFVGQRS
VEEYLLPYIE QALGDAIEAV IVNALDCLAV LCKSGFLRKR ILIEMIERSF PLLCYPSQWV
RRSVVTFLAS SSECLGAVDS YVFLAPVIQP FLRRQPASLD SEKALLSCLK PPVSREVFYE
VLQNARSSDM LERQRKIWYN SSAQSKQWEI ADLLEKGTGE LDSMKYWSDK QQSIGSHRPI
DSVLQQSGLT EVADDDAKLR ALGCNTRNAS SAIDMHDPLC SEKLQFSGLT SPQLNGLNSF
MCDKSSEGIP LYSFSMDKRA TVAPSAASDT PFPWMDPISK SFSLASSVPT PKLVSGSFGI
SAGSKQFYRV VHEPESREND QIANVNSKFQ DMGLSSTVKG SSVRMEDAST STDFTGLPSF
SRSSSIPDSG WRPRGVLVAH LQEHRSAVNN IAVSNDHSFF VSASDDSTVK VWDSRKLEKD
ISFRSRLTYH LEGSRALCTA MLRNSAQVVV GACDGTIHMF SVDHISKGLG NVVEKYSGIA
DIKKKDVKEG AILTLLNYPV DNCGIQTFMY STQNCGIHLW DTRSSSNAWT LKAIPEEGYI
SCLVAGPCGN WFVSGSSRGV LTLWDLRFRI PVNSWQYSLV CPVEKMCLFV PPSSVSVSTT
ARPLIYVAAG CNEVSLWNAE NGTCHQVFRA ANYDSDAEMS DLPWALARPS AKTSSKSDPT
RNANPRYRVD ELNEPPPRLP GIRSLLPLPS GDLLTGGTDL RIRRWDHFSP DRSYCICGPN
FKGVGNDDFY EARSSFGAQV VQETKRRPLT TKLTAKAVLV AAATDSAGCH HDSVLSLASV
KLNQRLLISS SRDGAIKVWK
//
