ID A0A1U8PK20_GOSHI Unreviewed; 823 AA.
AC A0A1U8PK20;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=ATP-dependent zinc metalloprotease FTSH 7, chloroplastic-like isoform X1 {ECO:0000313|RefSeq:XP_016750653.1};
GN Name=LOC107959175 {ECO:0000313|RefSeq:XP_016750653.1};
OS Gossypium hirsutum (Upland cotton) (Gossypium mexicanum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX NCBI_TaxID=3635 {ECO:0000313|Proteomes:UP000189702, ECO:0000313|RefSeq:XP_016750653.1};
RN [1] {ECO:0000313|Proteomes:UP000189702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TM-1 {ECO:0000313|Proteomes:UP000189702};
RX PubMed=25893780; DOI=10.1038/nbt.3208;
RA Li F., Fan G., Lu C., Xiao G., Zou C., Kohel R.J., Ma Z., Shang H., Ma X.,
RA Wu J., Liang X., Huang G., Percy R.G., Liu K., Yang W., Chen W., Du X.,
RA Shi C., Yuan Y., Ye W., Liu X., Zhang X., Liu W., Wei H., Wei S., Huang G.,
RA Zhang X., Zhu S., Zhang H., Sun F., Wang X., Liang J., Wang J., He Q.,
RA Huang L., Wang J., Cui J., Song G., Wang K., Xu X., Yu J.Z., Zhu Y., Yu S.;
RT "Genome sequence of cultivated Upland cotton (Gossypium hirsutum TM-1)
RT provides insights into genome evolution.";
RL Nat. Biotechnol. 33:524-530(2015).
RN [2] {ECO:0000313|RefSeq:XP_016750653.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_016750653.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SIMILARITY: In the C-terminal section; belongs to the peptidase M41
CC family. {ECO:0000256|ARBA:ARBA00010044}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the AAA ATPase
CC family. {ECO:0000256|ARBA:ARBA00010550}.
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DR RefSeq; XP_016750653.1; XM_016895164.1.
DR AlphaFoldDB; A0A1U8PK20; -.
DR STRING; 3635.A0A1U8PK20; -.
DR PaxDb; 3635-A0A1U8PK20; -.
DR GeneID; 107959175; -.
DR KEGG; ghi:107959175; -.
DR OMA; NSSCEHD; -.
DR OrthoDB; 117at2759; -.
DR Proteomes; UP000189702; Chromosome 10.
DR GO; GO:0009534; C:chloroplast thylakoid; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0004176; F:ATP-dependent peptidase activity; IBA:GO_Central.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IBA:GO_Central.
DR CDD; cd19501; RecA-like_FtsH; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 3.30.720.210; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.20.58.760; Peptidase M41; 1.
DR HAMAP; MF_01458; FtsH; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041569; AAA_lid_3.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR003960; ATPase_AAA_CS.
DR InterPro; IPR005936; FtsH.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011546; Pept_M41_FtsH_extracell.
DR InterPro; IPR000642; Peptidase_M41.
DR InterPro; IPR037219; Peptidase_M41-like.
DR NCBIfam; TIGR01241; FtsH_fam; 1.
DR PANTHER; PTHR23076:SF49; ATP-DEPENDENT ZINC METALLOPROTEASE FTSH 9, CHLOROPLASTIC; 1.
DR PANTHER; PTHR23076; METALLOPROTEASE M41 FTSH; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF17862; AAA_lid_3; 1.
DR Pfam; PF06480; FtsH_ext; 1.
DR Pfam; PF01434; Peptidase_M41; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF140990; FtsH protease domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00674; AAA; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049,
KW ECO:0000313|RefSeq:XP_016750653.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000189702};
KW Transit peptide {ECO:0000256|ARBA:ARBA00022946};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 377..517
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 91..134
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 95..109
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 110..127
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 823 AA; 89962 MW; 90067C0C0090C18B CRC64;
MSLIEFLRPT AIAIQSKCSR NSYCNLLYIH GLNLSTNRFK VSLQNTNRFI SDSITFPLCN
VLVLRNHERF NLYGGGRLRF KESKILANCT DNNDSKDSSS DKNESEGGQG VRQKQDTTNS
GSSTNQRREK SGKSELWWSK GKKWQWQPII QAQEIGVLLL QLGIVMFVMR LLRPGIPLPG
SEPRTPTTFI SVPYSEFLNK INSNQVQKVE VDGVHVMFKL KNEGNVQESE TSGVSNSEFQ
DSDLLLRSVA PTKRIVYTTI RPSDIKAPYE KMLENDVEFG SPDKRSGGFF NSALIALFYV
AVLAGLLHRF PVSFSQNTAG QIRNRKSGVS SISKVPEQGE IVTFADVAGV DEAKEELEEI
VEFLRNPDRY IRLGARPPRG VLLVGLPGTG KTLLAKAVAG EAEVPFISCS ASEFVELYVG
MGASRVRDLF ARAKKVAPSI IFIDEIDAVA KSRDGKFRIV SNDEREQTLN QLLTEMDGFD
SNSAVIVLGA TNRSDVLDPA LRRPGRFDRV VMVETPDRIG RESILKVHVS KKDIPLGEDV
DLCDIASMTT GFTGADLANL VNEAALLAGR NNKIIVERID FIQAVERSIA GIEKKTAKLK
GSEKAVVARH EAGHAVVGTA VANLLPGQPR VEKLSILPRS GGALGFTYTP PTNEDRYLLF
IDELRGRLVT LLGGRAAEEV VYSGRVSTGA LDDIRRATDM AYKAVAEYGL NQTIGPLSLA
TVSGGGMDES GGSVPWGRDQ GHLVDLVQRE VKALLQSALE VALSVVRANP TVLEGLGAHL
EENEKVEGEE LQEWLKLVVA PEELTVFIGG KQKSLLPVQA GSG
//
