ID A0A1U8PME7_GOSHI Unreviewed; 693 AA.
AC A0A1U8PME7;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=DNA (Cytosine-5)-methyltransferase DRM1-like isoform X1 {ECO:0000313|RefSeq:XP_016751513.1};
GN Name=LOC107959859 {ECO:0000313|RefSeq:XP_016751513.1};
OS Gossypium hirsutum (Upland cotton) (Gossypium mexicanum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX NCBI_TaxID=3635 {ECO:0000313|Proteomes:UP000189702, ECO:0000313|RefSeq:XP_016751513.1};
RN [1] {ECO:0000313|Proteomes:UP000189702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TM-1 {ECO:0000313|Proteomes:UP000189702};
RX PubMed=25893780; DOI=10.1038/nbt.3208;
RA Li F., Fan G., Lu C., Xiao G., Zou C., Kohel R.J., Ma Z., Shang H., Ma X.,
RA Wu J., Liang X., Huang G., Percy R.G., Liu K., Yang W., Chen W., Du X.,
RA Shi C., Yuan Y., Ye W., Liu X., Zhang X., Liu W., Wei H., Wei S., Huang G.,
RA Zhang X., Zhu S., Zhang H., Sun F., Wang X., Liang J., Wang J., He Q.,
RA Huang L., Wang J., Cui J., Song G., Wang K., Xu X., Yu J.Z., Zhu Y., Yu S.;
RT "Genome sequence of cultivated Upland cotton (Gossypium hirsutum TM-1)
RT provides insights into genome evolution.";
RL Nat. Biotechnol. 33:524-530(2015).
RN [2] {ECO:0000313|RefSeq:XP_016751513.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_016751513.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC superfamily. C5-methyltransferase family. {ECO:0000256|PROSITE-
CC ProRule:PRU01016}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_016751513.1; XM_016896024.1.
DR AlphaFoldDB; A0A1U8PME7; -.
DR STRING; 3635.A0A1U8PME7; -.
DR PaxDb; 3635-A0A1U8PME7; -.
DR GeneID; 107959859; -.
DR KEGG; ghi:107959859; -.
DR OrthoDB; 913973at2759; -.
DR Proteomes; UP000189702; Chromosome 10.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003886; F:DNA (cytosine-5-)-methyltransferase activity; IBA:GO_Central.
DR GO; GO:0006306; P:DNA methylation; IBA:GO_Central.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 2.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 2.
DR InterPro; IPR001525; C5_MeTfrase.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR030380; SAM_MeTfrase_DRM.
DR InterPro; IPR015940; UBA.
DR PANTHER; PTHR23068:SF25; DNA (CYTOSINE-5)-METHYLTRANSFERASE DRM2; 1.
DR PANTHER; PTHR23068; DNA CYTOSINE-5- -METHYLTRANSFERASE 3-RELATED; 1.
DR Pfam; PF00145; DNA_methylase; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 2.
DR PROSITE; PS51679; SAM_MT_C5; 1.
DR PROSITE; PS51680; SAM_MT_DRM; 1.
DR PROSITE; PS50030; UBA; 2.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU01016}; Reference proteome {ECO:0000313|Proteomes:UP000189702};
KW S-adenosyl-L-methionine {ECO:0000256|PROSITE-ProRule:PRU01016};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PROSITE-
KW ProRule:PRU01016}.
FT DOMAIN 68..109
FT /note="UBA"
FT /evidence="ECO:0000259|PROSITE:PS50030"
FT DOMAIN 117..158
FT /note="UBA"
FT /evidence="ECO:0000259|PROSITE:PS50030"
FT DOMAIN 359..688
FT /note="SAM-dependent MTase DRM-type"
FT /evidence="ECO:0000259|PROSITE:PS51680"
FT ACT_SITE 649
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01016"
SQ SEQUENCE 693 AA; 77410 MW; EC9588B51159EC3A CRC64;
MLRSFSWPIL QVKKMVDNNS GGEADNFDWD TEDDLEIDNY AISAPSGLST PCGEAVLGSA
EAGSSGNSPN SKIIDHFVGM GFSREMVAKV VEEKGEENSD LILEALLEYS ASTLPSSSNS
KLIDHFVGMG FSEEMVVKVV QENGEGNTDS ILETLLTYSA LETTASVQQN PDSGNCSSDY
EGSLLNDFSD FDSFSESEEI MSPSSEEGRK LLHLTKMGYS EAEASVVMER CGLCYLIHFC
NIFLLMVGRM SKFHLDSIKD PRLFNCCIEN GPDSTIEELT DFICAAQIAK AADALFPLED
KKPFSNGSSH KKRRNWGYDL LLRKKKLKLE KRFDEDDDAV HLPNPMIGFG VPNEPDQITN
RVLPEAALGP PYFYYENVAL APKGVWTTIS RFLYDVEPEF VDSKFFCAAA RKRGYVHNLP
IDNRFPLLPF PPRTIHEAFP LTRKWWPSWD TRTKLNCLQT CIASARLTDK IRKALEDSDG
EPPLGIQKFV LEQCRKWNLV WVGRNKVAPL EPDEVEMLLG FPRNHTRGGG ISRTDRYKSL
GNSFQIDTVA YHFSVLKDKF PGGINLLSLF SGIGGAEVAL HQLGIPLKNV VAVEIAELNR
NILRSWWEQT NQRGTLTDIQ DVQELNGDRL EQLIKNFGGF DLVVGGSPCN NLTGSNRYHR
DGLEGKDSAL FFDFCRILDL VKCIMNGTKS MII
//
