ID A0A1U8PU77_GOSHI Unreviewed; 1244 AA.
AC A0A1U8PU77;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=ABC transporter B family member 8 {ECO:0000313|RefSeq:XP_016754696.1};
GN Name=LOC107962725 {ECO:0000313|RefSeq:XP_016754696.1};
OS Gossypium hirsutum (Upland cotton) (Gossypium mexicanum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX NCBI_TaxID=3635 {ECO:0000313|Proteomes:UP000189702, ECO:0000313|RefSeq:XP_016754696.1};
RN [1] {ECO:0000313|Proteomes:UP000189702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TM-1 {ECO:0000313|Proteomes:UP000189702};
RX PubMed=25893780; DOI=10.1038/nbt.3208;
RA Li F., Fan G., Lu C., Xiao G., Zou C., Kohel R.J., Ma Z., Shang H., Ma X.,
RA Wu J., Liang X., Huang G., Percy R.G., Liu K., Yang W., Chen W., Du X.,
RA Shi C., Yuan Y., Ye W., Liu X., Zhang X., Liu W., Wei H., Wei S., Huang G.,
RA Zhang X., Zhu S., Zhang H., Sun F., Wang X., Liang J., Wang J., He Q.,
RA Huang L., Wang J., Cui J., Song G., Wang K., Xu X., Yu J.Z., Zhu Y., Yu S.;
RT "Genome sequence of cultivated Upland cotton (Gossypium hirsutum TM-1)
RT provides insights into genome evolution.";
RL Nat. Biotechnol. 33:524-530(2015).
RN [2] {ECO:0000313|RefSeq:XP_016754696.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_016754696.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_016754696.1; XM_016899207.1.
DR AlphaFoldDB; A0A1U8PU77; -.
DR STRING; 3635.A0A1U8PU77; -.
DR PaxDb; 3635-A0A1U8PU77; -.
DR GeneID; 107962725; -.
DR KEGG; ghi:107962725; -.
DR OrthoDB; 5487044at2759; -.
DR Proteomes; UP000189702; Chromosome 11.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR CDD; cd18577; ABC_6TM_Pgp_ABCB1_D1_like; 1.
DR CDD; cd18578; ABC_6TM_Pgp_ABCB1_D2_like; 1.
DR CDD; cd03249; ABC_MTABC3_MDL1_MDL2; 2.
DR Gene3D; 1.20.1560.10; ABC transporter type 1, transmembrane domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011527; ABC1_TM_dom.
DR InterPro; IPR036640; ABC1_TM_sf.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR039421; Type_1_exporter.
DR PANTHER; PTHR24222; ABC TRANSPORTER B FAMILY; 1.
DR PANTHER; PTHR24222:SF79; ABC TRANSPORTER B FAMILY MEMBER 15-LIKE ISOFORM X1; 1.
DR Pfam; PF00664; ABC_membrane; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF90123; ABC transporter transmembrane region; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS50929; ABC_TM1F; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000189702};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 26..48
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 90..109
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 165..185
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 191..212
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 271..291
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 303..324
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 686..709
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 721..739
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 40..331
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50929"
FT DOMAIN 366..602
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 680..967
FT /note="ABC transmembrane type-1"
FT /evidence="ECO:0000259|PROSITE:PS50929"
FT DOMAIN 1006..1242
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT REGION 606..660
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 629..648
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1244 AA; 136355 MW; 20965EA985B852EE CRC64;
MGSAEKTELG KNEFPRERER RHNICIIFRY ADWVDILLMV LGTIGAIGDG MSTNWLILFV
SRIMNSLGYG SNSQQNNNNF MGEVEKCTLY FTYLGLGSMV VAFMEGYCWS KTSERQVLKI
RYKYLEAILR QEVGFFDSQE ATTSEVINSI SKDTSLIQEV LSEKVPLFVM NTTAFFSGLA
FSAYLSWRLA LVVFPTILLL IIPGILYGKY LLYISKKASK EYGKANTIVE QALSSIKTVY
SFTAERRIVE RYTAILDRAV KLGLKQGIAK GLAVGSTGIS FAIWAFVAWY GSHLVMYKGE
SGGRVYTAGL CFILGGLALG VALADLKYFT EATVAAASIF SRVDRTPLIQ SEDTKGIVLD
TIRGDIEFDN VNFVYPSRPD SLVLKHFNLK VEAGKTVALV GASGSGKSTA IALVQRFYDA
NDGVVKIDGV DIRTLQLKWI RGKMGLVSQE HALFGTSIKE NIMFGKLDAT MDEVMTAAMA
ANAHNFIRQL PQGYETKIGE RGALLSGGQK QRIAIARAII KNPVILLLDE ATSALDSESE
TLVQNALDQA SMGRTTLVVA HKLSTVRNAD LIAVVNNGSI IEMGSHNDLI NMKDGHYAQL
TKLQRQFSSD DHEQNPETRL PSAGRMSGGR LSTAKSSPSP SPSFFATPLP NIESPKPVSH
PPPSFRRLLS LNSPEWKHGL MGSLSAIAFG AVQPVYALTI GGMISAFFAK SHQEMQARIR
TYAFIFSLLT LLSVILNLIQ QYNFAYMGER LTRRIRSRML EKILSFEAAW FDEEKNSTGA
LCSSLSNQAS MVKTLVADRI SLLVQTTSAV TIAMIIGLVV AWKLAIVMIA VQPLAIMCFY
TRKVLLSSVS TNFVKAQNQS TQIAVEAVYN HRIVTSFGSL GKVLQLFDEA QEEPRKEARK
KSWLAGIGMG SAQSLTFMSW ALDFWYGGTL VQKGEISAGD VFKTFFILVS TGKVIAEAGS
MTSDLAKGST AVASVFEILD RQSSISPGSQ GDGTNGIKLE RMSGKIELKK VDFAYPSRPE
TLVLRQFSLE VKPGRSVGLV GKSGCGKSTV VGLIQRFYDV EMGSVRVDGI DIRGLDVQWY
RRQMALVNQE PVIFSGTIRD NIVFGKLDAS ENEVVEAARA ANAHEFISAL KEGYETECGE
RGVQLSGGQK QRIAIARAII RNPKILLLDE ATSALDVQSE QVVQEALDRI MVGRTTVVIA
HRLNTIKKVD SIAFVADGKV VEQGTYAQLK NQHGAFSKLA SLQT
//
