ID A0A1U8PY94_GOSHI Unreviewed; 1265 AA.
AC A0A1U8PY94;
DT 10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT 10-MAY-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase {ECO:0000256|ARBA:ARBA00011982};
DE EC=3.2.2.6 {ECO:0000256|ARBA:ARBA00011982};
GN Name=LOC107963264 {ECO:0000313|RefSeq:XP_016755323.1};
OS Gossypium hirsutum (Upland cotton) (Gossypium mexicanum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Malvales; Malvaceae; Malvoideae; Gossypium.
OX NCBI_TaxID=3635 {ECO:0000313|Proteomes:UP000189702, ECO:0000313|RefSeq:XP_016755323.1};
RN [1] {ECO:0000313|Proteomes:UP000189702}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. TM-1 {ECO:0000313|Proteomes:UP000189702};
RX PubMed=25893780; DOI=10.1038/nbt.3208;
RA Li F., Fan G., Lu C., Xiao G., Zou C., Kohel R.J., Ma Z., Shang H., Ma X.,
RA Wu J., Liang X., Huang G., Percy R.G., Liu K., Yang W., Chen W., Du X.,
RA Shi C., Yuan Y., Ye W., Liu X., Zhang X., Liu W., Wei H., Wei S., Huang G.,
RA Zhang X., Zhu S., Zhang H., Sun F., Wang X., Liang J., Wang J., He Q.,
RA Huang L., Wang J., Cui J., Song G., Wang K., Xu X., Yu J.Z., Zhu Y., Yu S.;
RT "Genome sequence of cultivated Upland cotton (Gossypium hirsutum TM-1)
RT provides insights into genome evolution.";
RL Nat. Biotechnol. 33:524-530(2015).
RN [2] {ECO:0000313|RefSeq:XP_016755323.1}
RP IDENTIFICATION.
RC TISSUE=Leaf {ECO:0000313|RefSeq:XP_016755323.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide;
CC Xref=Rhea:RHEA:16301, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:57967; EC=3.2.2.6;
CC Evidence={ECO:0000256|ARBA:ARBA00000404};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16302;
CC Evidence={ECO:0000256|ARBA:ARBA00000404};
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DR RefSeq; XP_016755323.1; XM_016899834.1.
DR AlphaFoldDB; A0A1U8PY94; -.
DR PaxDb; 3635-A0A1U8PY94; -.
DR OrthoDB; 1055564at2759; -.
DR Proteomes; UP000189702; Chromosome 2.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 3.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR045344; C-JID.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR11017:SF559; DISEASE RESISTANCE PROTEIN (TIR-NBS-LRR CLASS) FAMILY; 1.
DR PANTHER; PTHR11017; LEUCINE-RICH REPEAT-CONTAINING PROTEIN; 1.
DR Pfam; PF20160; C-JID; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00369; LRR_TYP; 3.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 2.
DR PROSITE; PS50104; TIR; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000189702};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 14..180
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
FT COILED 121..148
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1265 AA; 143766 MW; 0E4453FFD08F9806 CRC64;
MSSLPSTSSS ISRKKYDVFL SFRGEDTRTN FTDHLYDALS RSGIVTFRDD PKLEAGEEIA
PELFTAIQQS WCSVIVFSQT YAFSSWCLEE LAEIVKQHNN DGHIVFPIFY DVDPSDLRKQ
KEKVEEAFAR HEERYKEDRE KIQRWRNALI QVAGIKGWHL NNRHESEFIK DIVKKISAKL
CQTYPATHSD LVGISERLED LYLKINIGED DVRVIGICGM GGIGKTTLAR VAYTQMSSHF
EGKSFIADIR EVSDKCGLVS LQKQLLSQIF HGECFNFFDV HEGSDIISHR LSHKKVLVVL
DNVDNIQHLK CLVGRHDWFG LGSRIVVTTR EEHLLRSWPV DDMYEPTTLN PKDALQLFSL
KAFHSDTVQK DDFIELSKHV VNYAGGLPLA LEVLGSFLCG RDATQWRSAI ERLKRDSNKE
ILDKLRISFD GLEEREKNIF LDIACFFNGE KKDFVIKVLD GCEFFPDIGI DVLIKKSLVK
VNKHNKYLNM HDLLQEMGRT IVKEKCVDEP GKRCRLWEER DVHHVLTKNT ATEMIEGIII
DNKRESNKMF NLSVDTFLKM KKLRLLKVLC LSNCDDLKYL SNELRLLNWT GYPLRYLPSS
FQPDNLVALL LPYSHIQQLW KGNRPLFNLK IMNLKGSQNL IKTPDFTTAS NLEVLILKGC
TKLVDVHPSI GVLKSLKLLN LRDCRSLRTL PTKIGMESLE TLILSGCSSL IRFPEIDGKM
ERLKTLDLSG CYRVENLSEN LQQAKFLEEL DLSETAITEP PSFIFQFKNL KVLSFNGRKG
PSYKLLPNLP PLLKVIQGRR TNPMARMLPL LPGMSSLREL KLRDCNLCEG DIPRDISGLS
CLEKLDLSGN NFISIPASLT RLSKLEILRL SNCNMCTFGE ADTHSDISGL SSLNILNLSD
NNFISIPASL TRLSNLGNLI LSNCNICTFG EADTHGDISG LSSLSYLNLS GKNFITLPLA
LTQLSRLKLL KLSGCKMLKS LPELPTRIAL LKIEGCSSLE VVASPSKVVR NLVGGVDICA
TNCFKLAEEI NAVMLLKEHI KAVQWFDRSD SFKIIIPGSE IPEWFSQQKS DSSIKIPLPI
NQLWKDSQWI GVACCCIFVN NDASMHDESI GCGVNIYCRN SEQASCNGSI FRGRNYELIN
WSGWGLDEPI MKDHLFLRYW SRDNFYPSLE DEYDDCETTN LWTTHCLDPK CDELEVSFRE
SSVKVKKCGV RIVYEKDLEE MKELQCDTTQ SSPNFEHIHQ HSAQNHGSVG STSHIKRKRN
IYEEM
//
