ID   A0A1U8Q7Z8_NELNU        Unreviewed;       762 AA.
AC   A0A1U8Q7Z8;
DT   10-MAY-2017, integrated into UniProtKB/TrEMBL.
DT   10-MAY-2017, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   RecName: Full=RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012493};
DE            EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493};
GN   Name=LOC109113903 {ECO:0000313|RefSeq:XP_019054205.1};
OS   Nelumbo nucifera (Sacred lotus).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Proteales; Nelumbonaceae; Nelumbo.
OX   NCBI_TaxID=4432 {ECO:0000313|Proteomes:UP000189703, ECO:0000313|RefSeq:XP_019054205.1};
RN   [1] {ECO:0000313|RefSeq:XP_019054205.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   RefSeq; XP_019054205.1; XM_019198660.1.
DR   STRING; 4432.A0A1U8Q7Z8; -.
DR   GeneID; 109113903; -.
DR   KEGG; nnu:109113903; -.
DR   InParanoid; A0A1U8Q7Z8; -.
DR   OrthoDB; 954380at2759; -.
DR   Proteomes; UP000189703; Unplaced.
DR   GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd00303; retropepsin_like; 1.
DR   CDD; cd09274; RNase_HI_RT_Ty3; 1.
DR   CDD; cd01647; RT_LTR; 1.
DR   Gene3D; 3.30.70.270; -; 2.
DR   Gene3D; 2.40.70.10; Acid Proteases; 1.
DR   Gene3D; 3.30.499.10; Aconitase, domain 3; 1.
DR   Gene3D; 3.10.10.10; HIV Type 1 Reverse Transcriptase, subunit A, domain 1; 1.
DR   InterPro; IPR015931; Acnase/IPM_dHydase_lsu_aba_1/3.
DR   InterPro; IPR001030; Acoase/IPM_deHydtase_lsu_aba.
DR   InterPro; IPR036008; Aconitase_4Fe-4S_dom.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR021109; Peptidase_aspartic_dom_sf.
DR   InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR   InterPro; IPR000477; RT_dom.
DR   InterPro; IPR041373; RT_RNaseH.
DR   PANTHER; PTHR34072; ENZYMATIC POLYPROTEIN-RELATED; 1.
DR   PANTHER; PTHR34072:SF46; RNA-DIRECTED DNA POLYMERASE HOMOLOG; 1.
DR   Pfam; PF00330; Aconitase; 1.
DR   Pfam; PF17917; RT_RNaseH; 1.
DR   Pfam; PF00078; RVT_1; 1.
DR   SUPFAM; SSF53732; Aconitase iron-sulfur domain; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
PE   4: Predicted;
KW   Iron {ECO:0000256|ARBA:ARBA00023004};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000189703}.
FT   DOMAIN          360..459
FT                   /note="Reverse transcriptase"
FT                   /evidence="ECO:0000259|Pfam:PF00078"
FT   DOMAIN          553..655
FT                   /note="Reverse transcriptase RNase H-like"
FT                   /evidence="ECO:0000259|Pfam:PF17917"
FT   DOMAIN          713..752
FT                   /note="Aconitase/3-isopropylmalate dehydratase large
FT                   subunit alpha/beta/alpha"
FT                   /evidence="ECO:0000259|Pfam:PF00330"
FT   REGION          27..89
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        28..43
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        66..81
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   762 AA;  86736 MW;  2B200145B16DC743 CRC64;
     MRATIVRGGQ RYQELRVYHR RCSKLEAQNS EKLPSQTVVN PKENASAVVL RSGKELQPQP
     SSPSKAAKGD KEKERHGSNE DPIEVISGPP LPKVTNVVIP PFPSRLQKSK KEEYEQEVLE
     TFRKVEINIP LLDAIKQLPK YAKFLKELCT NKRRLRIDEK VRIGENVSTV IKRTLLEKRA
     DPGMFTLPCV IGNKRIKRVM LDLGASINVM PYSIYCALRL GHLKETRVVI QLADRSNAYP
     KGIVEDVLVQ VNNLIFPADF YILKMEDDTV TIFGKEDMDD ELEFNAQSNK EEEFDASYDS
     PVPMPEQEAL ELELKALPDH LKYAYLGKKE TLLVIIAKGL TEEQEERLIK VLKEHKAAIG
     YYQIVIAQED QEKTTFTCXF GTFAYRRMPF GLCNALGTFQ RCMMSIFSYF IEKCIEMFMD
     DFTVYGDSFD DYLNSLSKIL NRCVETNLVL NYEKCHFMVN EDIVISARGI EVDKAKIDLI
     VSLPYPTNVR EIHSFLGHAG FYGRFIRDFS KIALLLSNLL QKDVPFNFGD ECKEAFGKLK
     RLLTIALIIQ PPDWNLPFEI MSDASNYAVG AALGQRIDGK SHVIYYASKT LNAAQSNYTT
     TEKELLAIVF ALDKFRSYLL GSKVIVFSDH AALKYLLAKE SKPRLIRWIL LLQEFDLEIK
     DQKGTENSVA DHLSRLVKGD DSSPISELFP DEQLFHIKEK TQTLQELISE MVKVEKVCVS
     TTNRNYPGRM GHKEGQIYLA SPYTAAASAL TGFVTDPREF LQ
//