ID A0A1U9JZQ5_9BURK Unreviewed; 187 AA.
AC A0A1U9JZQ5;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=RNA pyrophosphohydrolase {ECO:0000256|HAMAP-Rule:MF_00298};
DE EC=3.6.1.- {ECO:0000256|HAMAP-Rule:MF_00298};
DE AltName: Full=(Di)nucleoside polyphosphate hydrolase {ECO:0000256|HAMAP-Rule:MF_00298};
GN Name=rppH {ECO:0000256|HAMAP-Rule:MF_00298};
GN Synonyms=nudH {ECO:0000256|HAMAP-Rule:MF_00298};
GN ORFNames=K8U84_05645 {ECO:0000313|EMBL:HJH24023.1}, PAEH1_06165
GN {ECO:0000313|EMBL:AQS51241.1};
OS Paenalcaligenes hominis.
OC Bacteria; Pseudomonadota; Betaproteobacteria; Burkholderiales;
OC Alcaligenaceae; Paenalcaligenes.
OX NCBI_TaxID=643674 {ECO:0000313|EMBL:AQS51241.1, ECO:0000313|Proteomes:UP000189369};
RN [1] {ECO:0000313|EMBL:AQS51241.1, ECO:0000313|Proteomes:UP000189369}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=15S00501 {ECO:0000313|EMBL:AQS51241.1,
RC ECO:0000313|Proteomes:UP000189369};
RA Mukhopadhyay R., Joaquin J., Hogue R., Kilaru A., Jospin G., Mars K.,
RA Eisen J.A., Chaturvedi V.;
RT "Complete Genome Sequence of Paenalcaligenes hominis, Isolated from a
RT paraplegic Patient with neurogenic bladder.";
RL Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:HJH24023.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CHK175-13533 {ECO:0000313|EMBL:HJH24023.1};
RX PubMed=33868800;
RA Gilroy R., Ravi A., Getino M., Pursley I., Horton D.L., Alikhan N.F.,
RA Baker D., Gharbi K., Hall N., Watson M., Adriaenssens E.M.,
RA Foster-Nyarko E., Jarju S., Secka A., Antonio M., Oren A., Chaudhuri R.R.,
RA La Ragione R., Hildebrand F., Pallen M.J.;
RT "Extensive microbial diversity within the chicken gut microbiome revealed
RT by metagenomics and culture.";
RL PeerJ 9:0-0(2021).
RN [3] {ECO:0000313|EMBL:HJH24023.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CHK175-13533 {ECO:0000313|EMBL:HJH24023.1};
RA Gilroy R.;
RL Submitted (SEP-2021) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Accelerates the degradation of transcripts by removing
CC pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a
CC more labile monophosphorylated state that can stimulate subsequent
CC ribonuclease cleavage. {ECO:0000256|HAMAP-Rule:MF_00298}.
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- COFACTOR:
CC Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240;
CC Evidence={ECO:0000256|HAMAP-Rule:MF_00298};
CC -!- SIMILARITY: Belongs to the Nudix hydrolase family. RppH subfamily.
CC {ECO:0000256|HAMAP-Rule:MF_00298}.
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DR EMBL; CP019697; AQS51241.1; -; Genomic_DNA.
DR EMBL; DYTQ01000066; HJH24023.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1U9JZQ5; -.
DR STRING; 643674.PAEH1_06165; -.
DR KEGG; phn:PAEH1_06165; -.
DR OrthoDB; 9816040at2; -.
DR Proteomes; UP000189369; Chromosome.
DR Proteomes; UP000700248; Unassembled WGS sequence.
DR GO; GO:0016462; F:pyrophosphatase activity; IEA:UniProt.
DR CDD; cd03671; Ap4A_hydrolase_plant_like; 1.
DR Gene3D; 3.90.79.10; Nucleoside Triphosphate Pyrophosphohydrolase; 1.
DR HAMAP; MF_00298; Nudix_RppH; 1.
DR InterPro; IPR020476; Nudix_hydrolase.
DR InterPro; IPR015797; NUDIX_hydrolase-like_dom_sf.
DR InterPro; IPR020084; NUDIX_hydrolase_CS.
DR InterPro; IPR000086; NUDIX_hydrolase_dom.
DR InterPro; IPR022927; RppH.
DR PANTHER; PTHR23114; M7GPPPN-MRNA HYDROLASE; 1.
DR PANTHER; PTHR23114:SF17; M7GPPPN-MRNA HYDROLASE; 1.
DR Pfam; PF00293; NUDIX; 1.
DR PRINTS; PR00502; NUDIXFAMILY.
DR SUPFAM; SSF55811; Nudix; 1.
DR PROSITE; PS51462; NUDIX; 1.
DR PROSITE; PS00893; NUDIX_BOX; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00298};
KW Reference proteome {ECO:0000313|Proteomes:UP000189369}.
FT DOMAIN 6..149
FT /note="Nudix hydrolase"
FT /evidence="ECO:0000259|PROSITE:PS51462"
FT MOTIF 38..59
FT /note="Nudix box"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00298"
SQ SEQUENCE 187 AA; 22564 MW; EA9D3F57DEF401FC CRC64;
MLDREGYRPN VGIILVNRKN EVFWGKRIKE HAWQFPQGGI QQGESPVQAM YRELHEEVGL
LPEHVRILGR TRDWLRYNVP NHFVRREARG HYKGQKQIWF LLRMVGRDSD VSLRATETPE
FDAWRWSEYW VPLDAVIDFK REVYFQALNE LSVHVFKHKQ ETRFLRQRGY AAHRQRQNTE
LNLTHNN
//
