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Database: UniProt
Entry: A0A1U9K2Q9_9BURK
LinkDB: A0A1U9K2Q9_9BURK
Original site: A0A1U9K2Q9_9BURK 
ID   A0A1U9K2Q9_9BURK        Unreviewed;       352 AA.
AC   A0A1U9K2Q9;
DT   07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT   07-JUN-2017, sequence version 1.
DT   11-DEC-2019, entry version 10.
DE   RecName: Full=Phospho-2-dehydro-3-deoxyheptonate aldolase {ECO:0000256|PIRNR:PIRNR001361};
DE            EC=2.5.1.54 {ECO:0000256|PIRNR:PIRNR001361};
GN   ORFNames=PAEH1_04695 {ECO:0000313|EMBL:AQS52306.1};
OS   Paenalcaligenes hominis.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Alcaligenaceae; Paenalcaligenes.
OX   NCBI_TaxID=643674 {ECO:0000313|EMBL:AQS52306.1, ECO:0000313|Proteomes:UP000189369};
RN   [1] {ECO:0000313|EMBL:AQS52306.1, ECO:0000313|Proteomes:UP000189369}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=15S00501 {ECO:0000313|EMBL:AQS52306.1,
RC   ECO:0000313|Proteomes:UP000189369};
RA   Mukhopadhyay R., Joaquin J., Hogue R., Kilaru A., Jospin G., Mars K.,
RA   Eisen J.A., Chaturvedi V.;
RT   "Complete Genome Sequence of Paenalcaligenes hominis, Isolated from a
RT   paraplegic Patient with neurogenic bladder.";
RL   Submitted (JAN-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Stereospecific condensation of phosphoenolpyruvate (PEP) and
CC       D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-
CC       heptulosonate-7-phosphate (DAHP). {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-
CC         phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate;
CC         Xref=Rhea:RHEA:14717, ChEBI:CHEBI:15377, ChEBI:CHEBI:16897,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58394, ChEBI:CHEBI:58702; EC=2.5.1.54;
CC         Evidence={ECO:0000256|PIRNR:PIRNR001361};
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate biosynthesis;
CC       chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step
CC       1/7. {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- SIMILARITY: Belongs to the class-I DAHP synthase family.
CC       {ECO:0000256|PIRNR:PIRNR001361}.
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DR   EMBL; CP019697; AQS52306.1; -; Genomic_DNA.
DR   KEGG; phn:PAEH1_04695; -.
DR   KO; K01626; -.
DR   BioCyc; GCF_002005365:PAEH1_RS04685-MONOMER; -.
DR   UniPathway; UPA00053; UER00084.
DR   Proteomes; UP000189369; Chromosome.
DR   GO; GO:0003849; F:3-deoxy-7-phosphoheptulonate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009423; P:chorismate biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR006218; DAHP1/KDSA.
DR   InterPro; IPR006219; DHAP_synth_1.
DR   PANTHER; PTHR21225; PTHR21225; 1.
DR   Pfam; PF00793; DAHP_synth_1; 1.
DR   PIRSF; PIRSF001361; DAHP_synthase; 1.
DR   TIGRFAMs; TIGR00034; aroFGH; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Aromatic amino acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Transferase {ECO:0000256|PIRNR:PIRNR001361, ECO:0000256|SAAS:SAAS00080156}.
FT   DOMAIN          41..338
FT                   /note="DAHP_synth_1"
FT                   /evidence="ECO:0000259|Pfam:PF00793"
SQ   SEQUENCE   352 AA;  38755 MW;  F7C0AA331EDCF05F CRC64;
     MSHNTDDLRI REIKELSPPA HLMREFACSV DVSKVVHSAR QAIHNILHDQ DDRLVVVIGP
     CSIHDTEAAM DYARRLVPLR DKYKDELEIV MRVYFEKPRT TVGWKGLIND PNLDGSFNIN
     QGLRIARQLL LEVNALGLPA GCEYLDMITP QYIADLVSWG AIGARTTESQ VHRELASGLS
     CPVGFKNGTG GSTRIAIDAI KAASQPHHFL SVTKGGHSAI VSTKGNEDCH IILRGGKAPN
     HDAASVEQTG QEMTASGLLP RIMIDASHAN SNKDYRRQPE VINEVCEQVE QGDDRIFGVM
     VESHLVAGRQ DLVDGQPLTY GQSITDGCIG WEDSEAVLER LAQAVRVRRQ SK
//
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