ID A0A1U9KTM6_9PROT Unreviewed; 728 AA.
AC A0A1U9KTM6;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=ATP-dependent RecD-like DNA helicase {ECO:0000256|HAMAP-Rule:MF_01488};
DE EC=3.6.4.12 {ECO:0000256|HAMAP-Rule:MF_01488};
GN Name=recD2 {ECO:0000256|HAMAP-Rule:MF_01488,
GN ECO:0000313|EMBL:GEN16564.1};
GN ORFNames=A0U93_15525 {ECO:0000313|EMBL:AQS89092.1}, NCH01_29950
GN {ECO:0000313|EMBL:GEN16564.1};
OS Neoasaia chiangmaiensis.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodospirillales;
OC Acetobacteraceae; Neoasaia.
OX NCBI_TaxID=320497 {ECO:0000313|EMBL:AQS89092.1, ECO:0000313|Proteomes:UP000188604};
RN [1] {ECO:0000313|EMBL:AQS89092.1, ECO:0000313|Proteomes:UP000188604}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NBRC 101099 {ECO:0000313|EMBL:AQS89092.1,
RC ECO:0000313|Proteomes:UP000188604};
RA Brandt J., Jakob F., Vogel R.F.;
RT "Acetic acid bacteria sequencing.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:GEN16564.1, ECO:0000313|Proteomes:UP000321095}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NBRC 101099 {ECO:0000313|EMBL:GEN16564.1,
RC ECO:0000313|Proteomes:UP000321095};
RA Hosoyama A., Uohara A., Ohji S., Ichikawa N.;
RT "Whole genome shotgun sequence of Neoasaia chiangmaiensis NBRC 101099.";
RL Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase.
CC Has no activity on blunt DNA or DNA with 3'-overhangs, requires at
CC least 10 bases of 5'-ssDNA for helicase activity. {ECO:0000256|HAMAP-
CC Rule:MF_01488}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|HAMAP-Rule:MF_01488};
CC -!- SIMILARITY: Belongs to the RecD family. RecD-like subfamily.
CC {ECO:0000256|HAMAP-Rule:MF_01488}.
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DR EMBL; CP014691; AQS89092.1; -; Genomic_DNA.
DR EMBL; BJXS01000011; GEN16564.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1U9KTM6; -.
DR STRING; 320497.A0U93_15525; -.
DR KEGG; nch:A0U93_15525; -.
DR OrthoDB; 1826980at2; -.
DR Proteomes; UP000188604; Chromosome.
DR Proteomes; UP000321095; Unassembled WGS sequence.
DR GO; GO:0043139; F:5'-3' DNA helicase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR CDD; cd17933; DEXSc_RecD-like; 1.
DR CDD; cd18809; SF1_C_RecD; 1.
DR Gene3D; 1.10.10.2220; -; 1.
DR Gene3D; 2.30.30.940; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR HAMAP; MF_01488; RecD_like; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR006345; DNA_helicase_RecD-like.
DR InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR029493; RecD-like_HHH.
DR InterPro; IPR041451; RecD-like_SH13.
DR InterPro; IPR010994; RuvA_2-like.
DR InterPro; IPR027785; UvrD-like_helicase_C.
DR NCBIfam; TIGR01448; recD_rel; 1.
DR PANTHER; PTHR43788; DNA2/NAM7 HELICASE FAMILY MEMBER; 1.
DR PANTHER; PTHR43788:SF6; RECBCD ENZYME SUBUNIT RECD; 1.
DR Pfam; PF13245; AAA_19; 1.
DR Pfam; PF14490; HHH_4; 1.
DR Pfam; PF14520; HHH_5; 1.
DR Pfam; PF18335; SH3_13; 1.
DR Pfam; PF13538; UvrD_C_2; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00278; HhH1; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF47781; RuvA domain 2-like; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_01488}; DNA-binding {ECO:0000256|HAMAP-Rule:MF_01488};
KW Helicase {ECO:0000256|HAMAP-Rule:MF_01488, ECO:0000313|EMBL:GEN16564.1};
KW Hydrolase {ECO:0000256|HAMAP-Rule:MF_01488};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_01488}; Reference proteome {ECO:0000313|Proteomes:UP000188604}.
FT DOMAIN 128..147
FT /note="Helix-hairpin-helix DNA-binding motif class 1"
FT /evidence="ECO:0000259|SMART:SM00278"
FT DOMAIN 192..211
FT /note="Helix-hairpin-helix DNA-binding motif class 1"
FT /evidence="ECO:0000259|SMART:SM00278"
FT DOMAIN 344..541
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT BINDING 355..359
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01488"
SQ SEQUENCE 728 AA; 78989 MW; 7A30E3CE7A98AC50 CRC64;
MSGRAIDSSP TEALAGLVER VTFHNAENGF CVLRVKVRGQ RDLVTVVGHA AMISAGEFVQ
ISGRWFNDHS HGLQFKAEFL KASPPTTVEG IERYLGSGMI RGIGPVYAKK LVKAFGEAVF
DLIEQEPHRL REVTGIGPKR AERIVAGWAD QKVIREIMLF LHSNGVGTSR AVRIFKTYGQ
DAVKLISENP YRLAKDIRGI GFKTADQIAR KMGIAPDAMI RVRAGISYAL GEAMDEGHCG
LPVGELLTST AELLEVAAPL IEMALALELE AGDVIADSVG ETGCIFLAGL YRAEQSIAER
LRACAVGRPP WPEIDAAKAM TWVERKTGLA LAPSQQEAVR LALRSKVLVI TGGPGVGKTT
LVNAILKIVT AKGIDVQLCA PTGRAAKRLS ESTGLEGKTI HRLLETDPAT GSFNRDDTNP
LTCDLLVVDE ASMVDVLLMR SLLRALPDSA ALLIVGDVDQ LPSVGPGQVL ADIIGSGAVP
VVRLTEVFRQ AAQSRIITNA HRINEGRMPE LSAEEGSDFY FVEAGEPEIG LRRLLAVVKD
RIPARFGLDP VRDVQVLCPM NRGGLGARSL NIELQQALNP PAEVKVERFG WTYGPGDKVM
QIANDYDRDV FNGDLGVIDR IDIEEGELTV SFDGREIVYG FGELDELVLA YATTIHKSQG
SEYPAVVIPL VTQHYAMLAR NLLYTGVTRG RMLVVLVGQK KALAIAVRNQ GGRRRWSKLR
EWLMGSFA
//
