ID   A0A1U9ZQS3_9ACTN        Unreviewed;       408 AA.
AC   A0A1U9ZQS3;
DT   07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT   07-JUN-2017, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   SubName: Full=Ribonuclease D {ECO:0000313|EMBL:AQZ60303.1};
GN   ORFNames=BKM31_01140 {ECO:0000313|EMBL:AQZ60303.1};
OS   Nonomuraea sp. ATCC 55076.
OC   Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC   Streptosporangiaceae; Nonomuraea.
OX   NCBI_TaxID=1909395 {ECO:0000313|EMBL:AQZ60303.1, ECO:0000313|Proteomes:UP000190797};
RN   [1] {ECO:0000313|Proteomes:UP000190797}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 55076 {ECO:0000313|Proteomes:UP000190797};
RX   PubMed=28626548; DOI=10.1039/c6md00637j;
RA   Nazari B., Forneris C.C., Gibson M.I., Moon K., Schramma K.R.,
RA   Seyedsayamdost M.R.;
RT   "Nonomuraea sp. ATCC 55076 harbours the largest actinomycete chromosome to
RT   date and the kistamicin biosynthetic gene cluster.";
RL   Med. Chem. Commun. 8:780-788(2017).
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DR   EMBL; CP017717; AQZ60303.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1U9ZQS3; -.
DR   STRING; 1909395.BKM31_01140; -.
DR   KEGG; noa:BKM31_01140; -.
DR   OrthoDB; 144122at2; -.
DR   Proteomes; UP000190797; Chromosome.
DR   GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006139; P:nucleobase-containing compound metabolic process; IEA:InterPro.
DR   CDD; cd06142; RNaseD_exo; 1.
DR   Gene3D; 1.10.150.80; HRDC domain; 2.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR002562; 3'-5'_exonuclease_dom.
DR   InterPro; IPR041605; Exo_C.
DR   InterPro; IPR010997; HRDC-like_sf.
DR   InterPro; IPR002121; HRDC_dom.
DR   InterPro; IPR044876; HRDC_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   PANTHER; PTHR47649; RIBONUCLEASE D; 1.
DR   PANTHER; PTHR47649:SF1; RIBONUCLEASE D; 1.
DR   Pfam; PF01612; DNA_pol_A_exo1; 1.
DR   Pfam; PF18305; DNA_pol_A_exoN; 1.
DR   Pfam; PF00570; HRDC; 1.
DR   SMART; SM00474; 35EXOc; 1.
DR   SMART; SM00341; HRDC; 1.
DR   SUPFAM; SSF47819; HRDC-like; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR   PROSITE; PS50967; HRDC; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000190797}.
FT   DOMAIN          223..303
FT                   /note="HRDC"
FT                   /evidence="ECO:0000259|PROSITE:PS50967"
FT   REGION          300..323
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        307..321
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   408 AA;  44538 MW;  7189E59238678CEE CRC64;
     MTEERTVEPL LEPREGIPPV IADADGLAEV VARFAAGSGP VAVDAERASG YRYGNRAYLV
     QLRRAGAGTA LIDPIGCPDL SELDRAVADA EIVLHAASQD LPCLMEVGFR PRVMFDTELA
     GRLLGYERVG LGTMVETVLG LRLEKGHSAA DWSTRPLPED WLRYAALDVE VLVELRDVLH
     RELAEAGKLE WAREEFAAVL DTPPPAPRSD PWRRTSGIHK VRNVRALAIV RELWTMRDRI
     AREADLAPGR VLPDAAIVTA ALEGPRTKKA LTEISAFTGR SARRHMSDWL AAVARARSLP
     DSQLPQPSTP GDGPPPPNRW ADRDPAAAKR LAAARAVVAA LAEEHHMPTE NLLQPDAVRR
     LTWEPPSEIT EESVTARLRE LGARNWQLSL TAAPIAKALA RLGTRGEL
//