ID   A0A1U9ZXQ7_9ACTN        Unreviewed;       748 AA.
AC   A0A1U9ZXQ7;
DT   07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT   07-JUN-2017, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   RecName: Full=UvrABC system protein A {ECO:0000256|ARBA:ARBA00039316};
DE   AltName: Full=Excinuclease ABC subunit A {ECO:0000256|ARBA:ARBA00042156};
GN   ORFNames=BKM31_15725 {ECO:0000313|EMBL:AQZ62717.1};
OS   Nonomuraea sp. ATCC 55076.
OC   Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC   Streptosporangiaceae; Nonomuraea.
OX   NCBI_TaxID=1909395 {ECO:0000313|EMBL:AQZ62717.1, ECO:0000313|Proteomes:UP000190797};
RN   [1] {ECO:0000313|Proteomes:UP000190797}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 55076 {ECO:0000313|Proteomes:UP000190797};
RX   PubMed=28626548; DOI=10.1039/c6md00637j;
RA   Nazari B., Forneris C.C., Gibson M.I., Moon K., Schramma K.R.,
RA   Seyedsayamdost M.R.;
RT   "Nonomuraea sp. ATCC 55076 harbours the largest actinomycete chromosome to
RT   date and the kistamicin biosynthetic gene cluster.";
RL   Med. Chem. Commun. 8:780-788(2017).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. UvrA family.
CC       {ECO:0000256|ARBA:ARBA00038000}.
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DR   EMBL; CP017717; AQZ62717.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1U9ZXQ7; -.
DR   STRING; 1909395.BKM31_15725; -.
DR   KEGG; noa:BKM31_15725; -.
DR   OrthoDB; 9809851at2; -.
DR   Proteomes; UP000190797; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd03270; ABC_UvrA_I; 1.
DR   Gene3D; 1.10.8.280; ABC transporter ATPase domain-like; 1.
DR   Gene3D; 1.20.1580.10; ABC transporter ATPase like domain; 2.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR041552; UvrA_DNA-bd.
DR   PANTHER; PTHR43152:SF2; DRUG RESISTANCE ABC TRANSPORTER-RELATED; 1.
DR   PANTHER; PTHR43152; UVRABC SYSTEM PROTEIN A; 1.
DR   Pfam; PF17755; UvrA_DNA-bind; 1.
DR   SMART; SM00382; AAA; 2.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 3.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   DNA excision {ECO:0000256|ARBA:ARBA00022769};
KW   DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Excision nuclease {ECO:0000256|ARBA:ARBA00022881};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000190797};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT   DOMAIN          443..738
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000259|PROSITE:PS50893"
SQ   SEQUENCE   748 AA;  79819 MW;  C7A6B34D3CDA5ABD CRC64;
     MDDSIEITGA RVNNLKNVSL RIPKNHLVVF TGVSGSGKSS IVFDTIAAEA QRQLNETYTA
     FIRNRLPSYD KPDVETIDHL SATIVVDQKP VGGNARSTVG TMTDIMPILR ILFSRYGTPS
     AGYSFAYSFN DPAGMCPGCD GLGRAVRLDI DALIDDERSL DDGAIRFPLF GVGTWQWQIY
     ARSGTFDPAK PVRDYTPAER DLLLHGSGFT VDVHGKNGTL NKVDYEGVAD RFTRLYLRRD
     TSTLSERTRR AVADLITEGV CPQCHGARLN QAALATRIGP HTIADHAAME ITDLITVLDG
     LHNPVADAAA RALRRLDDIG LGYLTLDRET STVSGGEAQR LKTVRHLGSA LTGMTYVFDE
     PSAGLHPSDV GRLNTLLRAL RDKGNTVLVV EHDPDVIAIA DHVIDLGPGA GTHGGQVVFQ
     GDVAALTRAD TPTGRALRHR VPLKTSPRRP TGRLTLSPAT LHNLHQVALD LPTGVLTCIT
     GVAGSGKSTL ATRILPAQHP SVTVVDQSAP GTSARSSPAS YLGILDPIRR LFARATGTPP
     ALFSHNSDGA CPRCEGRGLI HTDLAFMDPI TTVCEMCAGT RYRPEALTHR LRGHSIADVL
     ALTAEQAAAF FTEPAVTARV HALLDVGLGY LTLGQPTSTL SGGELQRMKL AAELHRTGAI
     HVLDEPTTGL HLSDVQTLIA LLDRLVDGGN TVIVIEHHLD VVKRADWVID LGPGGGKHGG
     RVLFQGPPQD LVSAPGSITG AHLKAALG
//