ID   A0A1V0A1H7_9ACTN        Unreviewed;       493 AA.
AC   A0A1V0A1H7;
DT   07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT   07-JUN-2017, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   RecName: Full=Carboxylic ester hydrolase {ECO:0000256|RuleBase:RU361235};
DE            EC=3.1.1.- {ECO:0000256|RuleBase:RU361235};
GN   ORFNames=BKM31_23390 {ECO:0000313|EMBL:AQZ64012.1};
OS   Nonomuraea sp. ATCC 55076.
OC   Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC   Streptosporangiaceae; Nonomuraea.
OX   NCBI_TaxID=1909395 {ECO:0000313|EMBL:AQZ64012.1, ECO:0000313|Proteomes:UP000190797};
RN   [1] {ECO:0000313|Proteomes:UP000190797}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 55076 {ECO:0000313|Proteomes:UP000190797};
RX   PubMed=28626548; DOI=10.1039/c6md00637j;
RA   Nazari B., Forneris C.C., Gibson M.I., Moon K., Schramma K.R.,
RA   Seyedsayamdost M.R.;
RT   "Nonomuraea sp. ATCC 55076 harbours the largest actinomycete chromosome to
RT   date and the kistamicin biosynthetic gene cluster.";
RL   Med. Chem. Commun. 8:780-788(2017).
CC   -!- SIMILARITY: Belongs to the type-B carboxylesterase/lipase family.
CC       {ECO:0000256|ARBA:ARBA00005964, ECO:0000256|RuleBase:RU361235}.
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DR   EMBL; CP017717; AQZ64012.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1V0A1H7; -.
DR   STRING; 1909395.BKM31_23390; -.
DR   KEGG; noa:BKM31_23390; -.
DR   OrthoDB; 4308422at2; -.
DR   Proteomes; UP000190797; Chromosome.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR002018; CarbesteraseB.
DR   InterPro; IPR019826; Carboxylesterase_B_AS.
DR   InterPro; IPR002168; Lipase_GDXG_HIS_AS.
DR   PANTHER; PTHR43142; CARBOXYLIC ESTER HYDROLASE; 1.
DR   PANTHER; PTHR43142:SF1; CARBOXYLIC ESTER HYDROLASE; 1.
DR   Pfam; PF00135; COesterase; 1.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR   PROSITE; PS00122; CARBOXYLESTERASE_B_1; 1.
DR   PROSITE; PS01173; LIPASE_GDXG_HIS; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU361235};
KW   Reference proteome {ECO:0000313|Proteomes:UP000190797}.
FT   DOMAIN          5..460
FT                   /note="Carboxylesterase type B"
FT                   /evidence="ECO:0000259|Pfam:PF00135"
FT   REGION          42..70
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   493 AA;  51405 MW;  7233E09ADE8830A0 CRC64;
     MSRHDTVRTA QGLVRGLRRD GTIAFMNIPY AAAPTGAARF AAPRPHAPWD GVRDATAPGP
     TAPQAERRLG SVDMTPYFGP GWVPGDDFLT VNVWTPEAAG ERLPVMVFVH GGGFVAGSAR
     AGVLDGAAFA RDGVVLVTLN YRLGIAGFLD LPGAPANRGL LDVIAALRWV RENIAAFGGD
     PDRVTLSGQS AGATIVGAVL ATPESEGLFR RAIVQSGSGL GAFTPEQAAR VTRAAARALG
     VEPHAGAFAA VPDRRLVEVM PELSGLDLST ETHRDPLIGL SPFSVVLDRQ PAAAVAAGRG
     ADVELLVGTN TEEGNLYLAP FGSLSTSTAA DVEAAAARSH PRPAHLVAAY RKARPHASHG
     ELRAAIMGDA LFGVGSRRLA DAHAGSAAAT YRYSFAWRSK ALGGELGAAH AVELPFVFDV
     TGLPALHGPQ ALLGPDAPPP DLAARTHAAW VAFATTGDPG WDRYDTARRA TMRIGGTWEL
     LEDPDGDELR AWP
//