ID   A0A1V0A358_9ACTN        Unreviewed;       256 AA.
AC   A0A1V0A358;
DT   07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT   07-JUN-2017, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   SubName: Full=IclR family transcriptional regulator {ECO:0000313|EMBL:AQZ64646.1};
GN   ORFNames=BKM31_27125 {ECO:0000313|EMBL:AQZ64646.1};
OS   Nonomuraea sp. ATCC 55076.
OC   Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC   Streptosporangiaceae; Nonomuraea.
OX   NCBI_TaxID=1909395 {ECO:0000313|EMBL:AQZ64646.1, ECO:0000313|Proteomes:UP000190797};
RN   [1] {ECO:0000313|Proteomes:UP000190797}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 55076 {ECO:0000313|Proteomes:UP000190797};
RX   PubMed=28626548; DOI=10.1039/c6md00637j;
RA   Nazari B., Forneris C.C., Gibson M.I., Moon K., Schramma K.R.,
RA   Seyedsayamdost M.R.;
RT   "Nonomuraea sp. ATCC 55076 harbours the largest actinomycete chromosome to
RT   date and the kistamicin biosynthetic gene cluster.";
RL   Med. Chem. Commun. 8:780-788(2017).
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DR   EMBL; CP017717; AQZ64646.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1V0A358; -.
DR   STRING; 1909395.BKM31_27125; -.
DR   KEGG; noa:BKM31_27125; -.
DR   OrthoDB; 8479143at2; -.
DR   Proteomes; UP000190797; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR   Gene3D; 3.30.450.40; -; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR029016; GAF-like_dom_sf.
DR   InterPro; IPR014757; Tscrpt_reg_IclR_C.
DR   InterPro; IPR005471; Tscrpt_reg_IclR_N.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR30136; HELIX-TURN-HELIX TRANSCRIPTIONAL REGULATOR, ICLR FAMILY; 1.
DR   PANTHER; PTHR30136:SF24; HTH-TYPE TRANSCRIPTIONAL REPRESSOR ALLR; 1.
DR   Pfam; PF09339; HTH_IclR; 1.
DR   Pfam; PF01614; IclR; 1.
DR   SMART; SM00346; HTH_ICLR; 1.
DR   SUPFAM; SSF55781; GAF domain-like; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS51077; HTH_ICLR; 1.
DR   PROSITE; PS51078; ICLR_ED; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000190797};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT   DOMAIN          10..71
FT                   /note="HTH iclR-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51077"
FT   DOMAIN          72..256
FT                   /note="IclR-ED"
FT                   /evidence="ECO:0000259|PROSITE:PS51078"
SQ   SEQUENCE   256 AA;  27473 MW;  574762FCAEF862CB CRC64;
     MSEQNSADKL VGSDRVLAVL AELARHPDGI GLEEMARAVA SPKPTVHRAL AALRRAGFAA
     QHGHGRYVLG DEFLRMAFAH HEARPDHVRV MPVLKALCDR YGETAHYAVL DGPSVVYRSK
     LDPASGAVRL TSVVGGRNPA HCTAVGKVLL ADALPTREAV EAWADGRTLE RPTERSIGTV
     EELHAELTRI REQGYATDDQ ENEPGVNCVA VAAYLTSPTV PSGAISVSGL AYRTPLKRLI
     DDLPAIRAIV SGEEHS
//