ID A0A1V0A7J9_9ACTN Unreviewed; 390 AA.
AC A0A1V0A7J9;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE SubName: Full=Two-component sensor histidine kinase {ECO:0000313|EMBL:AQZ66149.1};
GN ORFNames=BKM31_36045 {ECO:0000313|EMBL:AQZ66149.1};
OS Nonomuraea sp. ATCC 55076.
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Streptosporangiaceae; Nonomuraea.
OX NCBI_TaxID=1909395 {ECO:0000313|EMBL:AQZ66149.1, ECO:0000313|Proteomes:UP000190797};
RN [1] {ECO:0000313|Proteomes:UP000190797}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 55076 {ECO:0000313|Proteomes:UP000190797};
RX PubMed=28626548; DOI=10.1039/c6md00637j;
RA Nazari B., Forneris C.C., Gibson M.I., Moon K., Schramma K.R.,
RA Seyedsayamdost M.R.;
RT "Nonomuraea sp. ATCC 55076 harbours the largest actinomycete chromosome to
RT date and the kistamicin biosynthetic gene cluster.";
RL Med. Chem. Commun. 8:780-788(2017).
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DR EMBL; CP017717; AQZ66149.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1V0A7J9; -.
DR STRING; 1909395.BKM31_36045; -.
DR KEGG; noa:BKM31_36045; -.
DR OrthoDB; 227596at2; -.
DR Proteomes; UP000190797; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR CDD; cd16917; HATPase_UhpB-NarQ-NarX-like; 1.
DR Gene3D; 1.20.5.1930; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR011712; Sig_transdc_His_kin_sub3_dim/P.
DR PANTHER; PTHR24421; NITRATE/NITRITE SENSOR PROTEIN NARX-RELATED; 1.
DR PANTHER; PTHR24421:SF10; SENSORY TRANSDUCTION HISTIDINE KINASE; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF07730; HisKA_3; 1.
DR SMART; SM00387; HATPase_c; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR PROSITE; PS50109; HIS_KIN; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:AQZ66149.1};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000190797};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT TRANSMEM 21..39
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 45..64
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 71..87
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 116..132
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 138..157
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 295..388
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT COILED 157..191
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 390 AA; 41748 MW; F13ACD384177ED5A CRC64;
MFGRVRAWSM RHSKLAGVLR VAPLGVLCAF LAIPYASVTP PEGHVYLRVG GYLALAAALV
VPLWWRDRLP LVTFAVVSLI SFGQWVADVD PQPANLAVLV ALWGVACQCA FRWALAACLV
AELGVFLALL NWEVPTFGMF FSGSILVVTV WVTGLYANTR RRYLEGLEER AERAERERDQ
QARMAAAAER ARIARELHDV VAHNVSVMVV QADGAGYALD SDPEQARLAV RNISKTGRAA
LAEMRRLVGV LRENEGGSTD YTPQPGLGQL EELVRGSAVP ASLRVGGAPA ELPEGQQLTV
YRIVQEALTN ALKHGGPGVE ATVEIDYLGS ELVVRVTDNG RGAAAPASPG GHGLIGMRER
VGMYGGAVSA RPRQGGGFEV LARLPMAKAA
//
