ID   A0A1V0AA15_9ACTN        Unreviewed;      1157 AA.
AC   A0A1V0AA15;
DT   07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT   07-JUN-2017, sequence version 1.
DT   24-JAN-2024, entry version 22.
DE   RecName: Full=Tetratricopeptide repeat protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=BKM31_41495 {ECO:0000313|EMBL:AQZ67070.1};
OS   Nonomuraea sp. ATCC 55076.
OC   Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC   Streptosporangiaceae; Nonomuraea.
OX   NCBI_TaxID=1909395 {ECO:0000313|EMBL:AQZ67070.1, ECO:0000313|Proteomes:UP000190797};
RN   [1] {ECO:0000313|Proteomes:UP000190797}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 55076 {ECO:0000313|Proteomes:UP000190797};
RX   PubMed=28626548; DOI=10.1039/c6md00637j;
RA   Nazari B., Forneris C.C., Gibson M.I., Moon K., Schramma K.R.,
RA   Seyedsayamdost M.R.;
RT   "Nonomuraea sp. ATCC 55076 harbours the largest actinomycete chromosome to
RT   date and the kistamicin biosynthetic gene cluster.";
RL   Med. Chem. Commun. 8:780-788(2017).
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DR   EMBL; CP017717; AQZ67070.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1V0AA15; -.
DR   STRING; 1909395.BKM31_41495; -.
DR   KEGG; noa:BKM31_41495; -.
DR   OrthoDB; 5521887at2; -.
DR   Proteomes; UP000190797; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR   CDD; cd00038; CAP_ED; 1.
DR   Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR   InterPro; IPR000595; cNMP-bd_dom.
DR   InterPro; IPR018490; cNMP-bd_dom_sf.
DR   InterPro; IPR012318; HTH_CRP.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR47691:SF3; HTH-TYPE TRANSCRIPTIONAL REGULATOR RV0890C-RELATED; 1.
DR   PANTHER; PTHR47691; REGULATOR-RELATED; 1.
DR   Pfam; PF00027; cNMP_binding; 1.
DR   Pfam; PF13545; HTH_Crp_2; 1.
DR   Pfam; PF13424; TPR_12; 3.
DR   Pfam; PF13181; TPR_8; 1.
DR   SMART; SM00028; TPR; 11.
DR   SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF48452; TPR-like; 4.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS50042; CNMP_BINDING_3; 1.
DR   PROSITE; PS51063; HTH_CRP_2; 1.
DR   PROSITE; PS50005; TPR; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000190797};
KW   TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT   DOMAIN          14..76
FT                   /note="Cyclic nucleotide-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS50042"
FT   DOMAIN          127..197
FT                   /note="HTH crp-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51063"
FT   REPEAT          858..891
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
SQ   SEQUENCE   1157 AA;  126940 MW;  E42A5D219F7A179E CRC64;
     MSLFRSLVDE GARPRVYHRN ETMCSPSRAD HHVYVIESGY AREYTPAGGR EAVHDLRGPG
     DLVGELAFWS PADRVRIDAL TEVRAWPIDL RRLREHASAA PAVATALVQE LFARNVAARR
     HEALARAPVA ARLAVWLLHL DERYGLGSEH APPLTMETLA DLVGSSADVV QRQITQWAQR
     GWLVRLRYRR LRIADPSALR GAAGSWEHLS APWAGRVTPF LVRPSGPADL LPVGEVPKPR
     QLPADMPDFI GRQRSLDLLT AWLERPRRTN TMVVQGLPGV GKTALVTHWG HLHADRFPDG
     QIVIDLRGQS PSQPPMSTVE ALGQILRSLG LGEPASDEAE LMLLYRSRIA GRKLLLILDN
     AADPAQVRAL LPGGRDCVVL VTSRTRMAPL RATGHADLMD LPVLDPGNAV ALLIAVLGED
     SPQAADRDAL AELARVCSYH PFALRISAAK LAENPGLSVQ SRAQELRRPD RPLVGDPEEA
     FTQALNLAYE SLTPVQRRAF RHVGLLPGRD FTPEVLAAAL GVPVSEAVVA VEGLHRAYLV
     EPLPGPRYRV HDLVKRLARE LGRHAEAGVR EARARLLDHY LAVATDPATP REWFEAERRS
     LVSAVRLAGE SGAHGMAWRL AEAVFEPFRR LRFYENNLEV QQGGLTSAMQ VGNRRAVALM
     RSRLGTLHRD IGPSTLAARL IGEALTDYAE LGDREGQARA LNELAEVHGI AGNSEDALRY
     ASQALDLYKE IDDPAGVAGC LHTLSRLHLS QERYEAALHH AGQALELREE LGDRRGTAQS
     LIILATVQRN LGEPDAALSE GLEALSICHE LGDEHAEAET LLCLAEIYDL LRLPHDARRD
     AERALAGYTA TGDQYGCGRA LCALGRIARN GSRYDEALSS YEQALSIQVE LHHEQGKAET
     LGDIGLVHWR LSDYLRADEY LSQALAISRV ISDGPVEARM LNRLARVRRR QGRPQVAFVY
     ALEALDIVQG LGNRRVEADV QETLTYTYLS LGQHKAALRA ARAALAIREE LRDNRGSALL
     SMAQALLAAG RSAQALEPAR EAVELQHESG TRDRWAAALT TLALVLLDLD RAGEALVHAR
     QARDTHRECG TRRDLGCALR ALGLISARLG HRAAAVAYLR EAVRTLEDVG DVFEARQVAE
     ELRLLHETPT KVVKSRA
//