ID   A0A1V0ADA1_9ACTN        Unreviewed;      1165 AA.
AC   A0A1V0ADA1;
DT   07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT   07-JUN-2017, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   SubName: Full=AfsR family transcriptional regulator {ECO:0000313|EMBL:AQZ68166.1};
GN   ORFNames=BKM31_47870 {ECO:0000313|EMBL:AQZ68166.1};
OS   Nonomuraea sp. ATCC 55076.
OC   Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC   Streptosporangiaceae; Nonomuraea.
OX   NCBI_TaxID=1909395 {ECO:0000313|EMBL:AQZ68166.1, ECO:0000313|Proteomes:UP000190797};
RN   [1] {ECO:0000313|Proteomes:UP000190797}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 55076 {ECO:0000313|Proteomes:UP000190797};
RX   PubMed=28626548; DOI=10.1039/c6md00637j;
RA   Nazari B., Forneris C.C., Gibson M.I., Moon K., Schramma K.R.,
RA   Seyedsayamdost M.R.;
RT   "Nonomuraea sp. ATCC 55076 harbours the largest actinomycete chromosome to
RT   date and the kistamicin biosynthetic gene cluster.";
RL   Med. Chem. Commun. 8:780-788(2017).
CC   -!- SIMILARITY: Belongs to the AfsR/DnrI/RedD regulatory family.
CC       {ECO:0000256|ARBA:ARBA00005820}.
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DR   EMBL; CP017717; AQZ68166.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1V0ADA1; -.
DR   STRING; 1909395.BKM31_47870; -.
DR   KEGG; noa:BKM31_47870; -.
DR   Proteomes; UP000190797; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:InterPro.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR   CDD; cd15831; BTAD; 1.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR005158; BTAD.
DR   InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR47691:SF3; HTH-TYPE TRANSCRIPTIONAL REGULATOR RV0890C-RELATED; 1.
DR   PANTHER; PTHR47691; REGULATOR-RELATED; 1.
DR   Pfam; PF03704; BTAD; 1.
DR   Pfam; PF13424; TPR_12; 1.
DR   Pfam; PF00486; Trans_reg_C; 1.
DR   SMART; SM01043; BTAD; 1.
DR   SMART; SM00028; TPR; 4.
DR   SMART; SM00862; Trans_reg_C; 1.
DR   SUPFAM; SSF46894; C-terminal effector domain of the bipartite response regulators; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF48452; TPR-like; 3.
DR   PROSITE; PS51755; OMPR_PHOB; 1.
PE   3: Inferred from homology;
KW   DNA-binding {ECO:0000256|PROSITE-ProRule:PRU01091};
KW   Reference proteome {ECO:0000313|Proteomes:UP000190797}.
FT   DOMAIN          1..90
FT                   /note="OmpR/PhoB-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51755"
FT   DNA_BIND        1..90
FT                   /note="OmpR/PhoB-type"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01091"
FT   REGION          303..343
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1165 AA;  122712 MW;  D5A93EE77AF51748 CRC64;
     MQFGVLGPLA VWDADGGPVT VGGPRPRALL AMLLLDAGRL VSVERLIDGQ YGDRPPTGAA
     NAVQAQVSRL RRHLPAGLIE FHGTGYRLAT EPDTVDAHRF ERLTREGRRL LAAGLPAQAA
     ALLREALALW RGPALADVAG APFAQPQAVR LEELRLTATE DLYEAELSLP DARPAAGLRE
     LVAAHPLRER GRELLMRALH AAGRQAEALA AYEEGRRLLA DELGADPSPS LAALHLAILR
     GHPDPGGPPA RPPAVRTGVP AQLTSFVGRE DELARLAALG SARLVTIVGP GGTGKTRLAI
     ESTTHRPALS RPAGPPATGP VPTQRASAQG ALPGAGGAPI PPDDGARAAG AVAFVDLSLV
     DGPREAVASG VRGTSVDGQV AHVVLGALGL REPALRPAAA GGPDPVERLV AALAGQELRL
     VLDNCEHVID EAATLARRLL AQCPGVTILA TSREPLGITG EHIVPLSPLP TPPPDARDPL
     SYPAVRLFAD RAAAVRQGFA LDPGNLDAVL RICAALDGLP LAIELAAARV RTFGVAEIAD
     RLAEHGRFRL LSRGDRTAAA RHQTLHAVVE WSWSLLGPAE QALARRLSVF TGGATLEAAE
     RVCGAAGPPG QPGDLTSGGT WTDATGGTWT DPSGGAWADP TGGTSADATG GTWTDLADGL
     ADLVDKSLVE TDGERYQMLD TIRLFCLERL AEAGEEERLR QAHAAWFLEF AANAHDHLYR
     REQLDWLARL SADNANLQSA LRWSVEHDPP TAWRLVGTLG MYWWLTGRRG EATRHAERLL
     DGTGGTPPAD LEEEYVLAVL HAVPDTGSPH WARAKKIVAS LERPMRYRFG VALWGMIAGP
     PDGGVPTDRT SELVLSSDPW SRALDRLGIA LMLLHSGRIA DAEAGMDRVL AAFRALGERW
     GMGQAFDWLA LIASWRGDWR RAMELWDRAL ALFAELGALD ELADVLSRRA NAHWRAGDPV
     AARADIERAG ELERRLGRPE LMAWVQLQLG DIARLQGDLP EAERRLEAAL SGSETGAFTA
     GGMRSRVHTA LARLAAARGD VERAARLHAQ ALAIALDSPL ANDVAEVAEG LAAHALHQAT
     RAAGDADRAV GDAGRASREA GERAALLLGI GAAVRGMAVA GDRDVAATAA GATRVLGPEG
     FAAAYAKGVA LTREEALTTL RAAAS
//