ID A0A1V0AIB5_9ACTN Unreviewed; 339 AA.
AC A0A1V0AIB5;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE SubName: Full=Type III polyketide synthase {ECO:0000313|EMBL:AQZ69822.1};
GN ORFNames=BKM31_57665 {ECO:0000313|EMBL:AQZ69822.1};
OS Nonomuraea sp. ATCC 55076.
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Streptosporangiaceae; Nonomuraea.
OX NCBI_TaxID=1909395 {ECO:0000313|EMBL:AQZ69822.1, ECO:0000313|Proteomes:UP000190797};
RN [1] {ECO:0000313|Proteomes:UP000190797}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 55076 {ECO:0000313|Proteomes:UP000190797};
RX PubMed=28626548; DOI=10.1039/c6md00637j;
RA Nazari B., Forneris C.C., Gibson M.I., Moon K., Schramma K.R.,
RA Seyedsayamdost M.R.;
RT "Nonomuraea sp. ATCC 55076 harbours the largest actinomycete chromosome to
RT date and the kistamicin biosynthetic gene cluster.";
RL Med. Chem. Commun. 8:780-788(2017).
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Chalcone/stilbene
CC synthases family. {ECO:0000256|ARBA:ARBA00005531}.
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DR EMBL; CP017717; AQZ69822.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1V0AIB5; -.
DR STRING; 1909395.BKM31_57665; -.
DR KEGG; noa:BKM31_57665; -.
DR Proteomes; UP000190797; Chromosome.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR CDD; cd00831; CHS_like; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR012328; Chalcone/stilbene_synt_C.
DR InterPro; IPR001099; Chalcone/stilbene_synt_N.
DR InterPro; IPR011141; Polyketide_synthase_type-III.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR11877:SF99; 1,3,6,8-TETRAHYDROXYNAPHTHALENE SYNTHASE; 1.
DR PANTHER; PTHR11877; HYDROXYMETHYLGLUTARYL-COA SYNTHASE; 1.
DR Pfam; PF02797; Chal_sti_synt_C; 1.
DR Pfam; PF00195; Chal_sti_synt_N; 1.
DR PIRSF; PIRSF000451; PKS_III; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000190797}.
FT DOMAIN 6..194
FT /note="Chalcone/stilbene synthase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00195"
FT DOMAIN 204..338
FT /note="Chalcone/stilbene synthase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02797"
FT ACT_SITE 135
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000451-1"
SQ SEQUENCE 339 AA; 36480 MW; 71F6BE4B983F635B CRC64;
MHISGVQTVL PDHRYEQAEI TEAFSRLTDC DEELLRRFHQ ATGVRGRNLA LPLADYAKLD
SFARANDAYV EHALELGEQA LAGALHKADV RPEKVDHLLF CSTTGLATPS LDAKLAQRMG
LRPDVKRVPV FGLGCAAGAA GLSRLHDYLR GWPDHVAVLV CVELCSLTIQ RDDTSIANLV
ASGLFGDGAA AVVATGRGPG PEVVATRSRL YPGTEHLMGW EVGEHGFRIV LDADLTGFVE
EVLAADIRAF LADYGLTPEQ VATWVCHPGG PKVIEKIVET LGLPAKALDV TWSSLREHGN
LSSVSVLHVL QETRGRPGTP AVLMALGPGF SAELLLLHW
//
