ID   A0A1V0ALC5_9ACTN        Unreviewed;       340 AA.
AC   A0A1V0ALC5;
DT   07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT   07-JUN-2017, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Adenosine deaminase {ECO:0000313|EMBL:AQZ71031.1};
GN   ORFNames=BKM31_40770 {ECO:0000313|EMBL:AQZ71031.1};
OS   Nonomuraea sp. ATCC 55076.
OC   Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC   Streptosporangiaceae; Nonomuraea.
OX   NCBI_TaxID=1909395 {ECO:0000313|EMBL:AQZ71031.1, ECO:0000313|Proteomes:UP000190797};
RN   [1] {ECO:0000313|Proteomes:UP000190797}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 55076 {ECO:0000313|Proteomes:UP000190797};
RX   PubMed=28626548; DOI=10.1039/c6md00637j;
RA   Nazari B., Forneris C.C., Gibson M.I., Moon K., Schramma K.R.,
RA   Seyedsayamdost M.R.;
RT   "Nonomuraea sp. ATCC 55076 harbours the largest actinomycete chromosome to
RT   date and the kistamicin biosynthetic gene cluster.";
RL   Med. Chem. Commun. 8:780-788(2017).
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Adenosine and AMP deaminases family. {ECO:0000256|ARBA:ARBA00006676}.
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DR   EMBL; CP017717; AQZ71031.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1V0ALC5; -.
DR   STRING; 1909395.BKM31_40770; -.
DR   KEGG; noa:BKM31_40770; -.
DR   OrthoDB; 105475at2; -.
DR   Proteomes; UP000190797; Chromosome.
DR   GO; GO:0019239; F:deaminase activity; IEA:InterPro.
DR   GO; GO:0016814; F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines; IEA:UniProt.
DR   GO; GO:0009168; P:purine ribonucleoside monophosphate biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR   InterPro; IPR006650; A/AMP_deam_AS.
DR   InterPro; IPR001365; A_deaminase_dom.
DR   InterPro; IPR006330; Ado/ade_deaminase.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   NCBIfam; TIGR01430; aden_deam; 1.
DR   PANTHER; PTHR43114; ADENINE DEAMINASE; 1.
DR   PANTHER; PTHR43114:SF6; ADENINE DEAMINASE; 1.
DR   Pfam; PF00962; A_deaminase; 1.
DR   SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
DR   PROSITE; PS00485; A_DEAMINASE; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000190797}.
FT   DOMAIN          9..334
FT                   /note="Adenosine deaminase"
FT                   /evidence="ECO:0000259|Pfam:PF00962"
SQ   SEQUENCE   340 AA;  37489 MW;  070D583FFEC46AD4 CRC64;
     MLRPLHALPK AHLHLHFTGS MRHSTLIELA REQGLTLPDA LEQDWPPKLR ATDERGWFRF
     QRLYDIARSV LTRPEHVYRL MRETAEDEVA AGSRWLEIQV DPSGYAQRFG GLTATLELML
     DAVEQASRHA GVGMAVVVAA NRTRHPLDAN TLARLATQYA GKGVIGFGLS NDERRAQARD
     FERAFRIAKR GGLLAVPHGG ELLGPRSVAQ CVDDLGADRV GHGVRAAEDE WLMQRLADRQ
     ICCEVCPTSN VGLGVVEEAA DVPVRRLFDA GVPIALGADD PLLFGTRLLR QYELAREVYG
     FGDAEVAELA RQSVRSSAAP ESVRKELLKG VDDWLTGALH
//