ID A0A1V0ALL0_9ACTN Unreviewed; 439 AA.
AC A0A1V0ALL0;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=B12-binding domain/radical SAM domain-containing protein {ECO:0000313|EMBL:AQZ71105.1};
GN ORFNames=BKM31_44230 {ECO:0000313|EMBL:AQZ71105.1};
OS Nonomuraea sp. ATCC 55076.
OC Bacteria; Actinomycetota; Actinomycetes; Streptosporangiales;
OC Streptosporangiaceae; Nonomuraea.
OX NCBI_TaxID=1909395 {ECO:0000313|EMBL:AQZ71105.1, ECO:0000313|Proteomes:UP000190797};
RN [1] {ECO:0000313|Proteomes:UP000190797}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 55076 {ECO:0000313|Proteomes:UP000190797};
RX PubMed=28626548; DOI=10.1039/c6md00637j;
RA Nazari B., Forneris C.C., Gibson M.I., Moon K., Schramma K.R.,
RA Seyedsayamdost M.R.;
RT "Nonomuraea sp. ATCC 55076 harbours the largest actinomycete chromosome to
RT date and the kistamicin biosynthetic gene cluster.";
RL Med. Chem. Commun. 8:780-788(2017).
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
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DR EMBL; CP017717; AQZ71105.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1V0ALL0; -.
DR STRING; 1909395.BKM31_44230; -.
DR KEGG; noa:BKM31_44230; -.
DR OrthoDB; 5298546at2; -.
DR Proteomes; UP000190797; Chromosome.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031419; F:cobalamin binding; IEA:InterPro.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR CDD; cd01335; Radical_SAM; 1.
DR Gene3D; 3.40.50.280; Cobalamin-binding domain; 1.
DR Gene3D; 3.80.30.20; tm_1862 like domain; 1.
DR InterPro; IPR023980; CHP04013_B12-bd/rSAM.
DR InterPro; IPR006158; Cobalamin-bd.
DR InterPro; IPR006638; Elp3/MiaA/NifB-like_rSAM.
DR InterPro; IPR007197; rSAM.
DR InterPro; IPR023404; rSAM_horseshoe.
DR NCBIfam; TIGR04013; B12_SAM_MJ_1487; 1.
DR PANTHER; PTHR43409:SF7; ANAEROBIC MAGNESIUM-PROTOPORPHYRIN IX MONOMETHYL ESTER CYCLASE; 1.
DR PANTHER; PTHR43409; ANAEROBIC MAGNESIUM-PROTOPORPHYRIN IX MONOMETHYL ESTER CYCLASE-RELATED; 1.
DR Pfam; PF04055; Radical_SAM; 1.
DR SFLD; SFLDG01082; B12-binding_domain_containing; 1.
DR SFLD; SFLDS00029; Radical_SAM; 1.
DR SMART; SM00729; Elp3; 1.
DR SUPFAM; SSF102114; Radical SAM enzymes; 1.
DR PROSITE; PS51332; B12_BINDING; 1.
DR PROSITE; PS51918; RADICAL_SAM; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000190797}.
FT DOMAIN 13..144
FT /note="B12-binding"
FT /evidence="ECO:0000259|PROSITE:PS51332"
FT DOMAIN 174..413
FT /note="Radical SAM core"
FT /evidence="ECO:0000259|PROSITE:PS51918"
SQ SEQUENCE 439 AA; 47778 MW; BBEA6586A75DA98D CRC64;
MRRPVAWATL PDVALAVDVV VRYRKAVTYG VHALLAALDT AKVQHGLRLG TTPEETAAHI
QASQADRVLV LWSFYSPDAD AMAAELAEVR ALSGGRGLHI AGGVHATAEP QQVIDAGWDL
AGIGEGESTI ISLVRALQED APLTTVPGLA IKDADGVALR TRPAPQLPLD AFPSFVGRSG
PIEITRGCRY TCRFCQTPFM FGGQFRHRSV ASVREHVRGM VERGLRDVRF ITPTSLSYGS
PGPDPDLGAV EELLSGVKEE LPPHGRVFFG SFPSEVRPEH VTPEAMRLLK RYVANDNLII
GAQSGSDRVL AASGRGHDTS PVRDAVRIAV EHGFRPNVDF IFGMPGESES DQAQSLRLAG
DLADLGARIH THTFMPLPGT PWRDAEPAFI PLETMSELDR LAQRGDAYGH WRRQAEHAVR
LAEAAKAYPR RTRRRRATD
//
