ID A0A1V0GPZ1_9RHOB Unreviewed; 49 AA.
AC A0A1V0GPZ1;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=DNA gyrase inhibitor YacG {ECO:0000256|HAMAP-Rule:MF_00649};
GN Name=yacG {ECO:0000256|HAMAP-Rule:MF_00649,
GN ECO:0000313|EMBL:MBY0137679.1};
GN ORFNames=A6J80_05570 {ECO:0000313|EMBL:ARC35922.1}, CDV54_15485
GN {ECO:0000313|EMBL:OWJ91006.1}, FOB51_18195
GN {ECO:0000313|EMBL:QEU09780.1}, H7K23_16630
GN {ECO:0000313|EMBL:MBY0137679.1}, PYTT13_00875
GN {ECO:0000313|EMBL:ATQ54502.1};
OS Paracoccus yeei.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Paracoccaceae; Paracoccus.
OX NCBI_TaxID=147645 {ECO:0000313|EMBL:ARC35922.1, ECO:0000313|Proteomes:UP000191257};
RN [1] {ECO:0000313|Proteomes:UP000191257}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FDAARGOS_252 {ECO:0000313|Proteomes:UP000191257};
RA Minogue T., Wolcott M., Wasieloski L., Aguilar W., Moore D., Tallon L.,
RA Sadzewicz L., Sengamalay N., Ott S., Godinez A., Nagaraj S., Nadendla S.,
RA Geyer C., Sichtig H.;
RT "FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS):
RT Supporting development and validation of Infectious Disease Dx tests.";
RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:OWJ91006.1, ECO:0000313|Proteomes:UP000196844}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=G1212 {ECO:0000313|EMBL:OWJ91006.1,
RC ECO:0000313|Proteomes:UP000196844};
RA Nicholson A.C., Sammons S., Humrighouse B.W., Graziano J., Lasker B.,
RA Whitney A.M., Mcquiston J.R.;
RT "Paracoccus genomes.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ATQ54502.1, ECO:0000313|Proteomes:UP000229314}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TT13 {ECO:0000313|EMBL:ATQ54502.1,
RC ECO:0000313|Proteomes:UP000229314};
RA Lee K., Lim J.Y., Hwang I.;
RT "Complete genome sequence of Paracoccus yeei TT13 isolated from human
RT skin.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:ARC35922.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FDAARGOS_252 {ECO:0000313|EMBL:ARC35922.1};
RA Campos J., Goldberg B., Tallon L., Sadzewicz L., Sengamalay N., Ott S.,
RA Godinez A., Nagaraj S., Vyas G., Aluvathingal J., Nadendla S., Geyer C.,
RA Nandy P., Hobson J., Sichtig H.;
RT "FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS):
RT Supporting development and validation of Infectious Disease Dx tests.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
RN [5] {ECO:0000313|EMBL:QEU09780.1, ECO:0000313|Proteomes:UP000324507}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FDAARGOS_643 {ECO:0000313|EMBL:QEU09780.1,
RC ECO:0000313|Proteomes:UP000324507};
RA Sciortino C., Tallon L., Sadzewicz L., Vavikolanu K., Mehta A.,
RA Aluvathingal J., Nadendla S., Nandy P., Geyer C., Yan Y., Sichtig H.;
RT "FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS):
RT Supporting development and validation of Infectious Disease Dx tests.";
RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000313|EMBL:MBY0137679.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=S/N-202-OC-B2 {ECO:0000313|EMBL:MBY0137679.1};
RA Seuylemezian A., Singh N.K., Wood J., Venkateswaran K.;
RT "Fungal Genomes of the International Space Station.";
RL Submitted (AUG-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Inhibits all the catalytic activities of DNA gyrase by
CC preventing its interaction with DNA. Acts by binding directly to the C-
CC terminal domain of GyrB, which probably disrupts DNA binding by the
CC gyrase. {ECO:0000256|HAMAP-Rule:MF_00649}.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|HAMAP-Rule:MF_00649};
CC Note=Binds 1 zinc ion. {ECO:0000256|HAMAP-Rule:MF_00649};
CC -!- SUBUNIT: Interacts with GyrB. {ECO:0000256|HAMAP-Rule:MF_00649}.
CC -!- SIMILARITY: Belongs to the DNA gyrase inhibitor YacG family.
CC {ECO:0000256|HAMAP-Rule:MF_00649}.
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DR EMBL; CP020442; ARC35922.1; -; Genomic_DNA.
DR EMBL; CP024422; ATQ54502.1; -; Genomic_DNA.
DR EMBL; JACLBQ010000066; MBY0137679.1; -; Genomic_DNA.
DR EMBL; NIPZ01000065; OWJ91006.1; -; Genomic_DNA.
DR EMBL; CP044081; QEU09780.1; -; Genomic_DNA.
DR RefSeq; WP_028718001.1; NZ_NIPZ01000065.1.
DR STRING; 147645.A6J80_05570; -.
DR GeneID; 78896219; -.
DR KEGG; pye:A6J80_05570; -.
DR eggNOG; COG3024; Bacteria.
DR OrthoDB; 9809663at2; -.
DR Proteomes; UP000191257; Chromosome.
DR Proteomes; UP000196844; Unassembled WGS sequence.
DR Proteomes; UP000229314; Chromosome.
DR Proteomes; UP000324507; Chromosome.
DR Proteomes; UP000756578; Unassembled WGS sequence.
DR GO; GO:0008657; F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) inhibitor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR HAMAP; MF_00649; DNA_gyrase_inhibitor_YacG; 1.
DR InterPro; IPR005584; DNA_gyrase_inhibitor_YacG.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR36150; DNA GYRASE INHIBITOR YACG; 1.
DR PANTHER; PTHR36150:SF1; DNA GYRASE INHIBITOR YACG; 1.
DR Pfam; PF03884; YacG; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|HAMAP-
KW Rule:MF_00649}; Reference proteome {ECO:0000313|Proteomes:UP000191257};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|HAMAP-Rule:MF_00649}.
FT BINDING 3
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00649"
FT BINDING 6
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00649"
FT BINDING 18
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00649"
FT BINDING 22
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00649"
SQ SEQUENCE 49 AA; 5557 MW; CA966303C702DFBE CRC64;
MTCPICGKPA VPRYRPFCSR RCADVDLAHW LRGDYRIPAE PVPDADPDE
//
