ID A0A1V0GUG1_9RHOB Unreviewed; 421 AA.
AC A0A1V0GUG1;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Insulinase family protein {ECO:0000313|EMBL:ARC37458.1};
DE EC=3.4.24.64 {ECO:0000313|EMBL:AYF00308.1};
GN ORFNames=A6J80_14755 {ECO:0000313|EMBL:ARC37458.1}, FOB51_08855
GN {ECO:0000313|EMBL:QEU08097.1}, H7K23_04745
GN {ECO:0000313|EMBL:MBY0135366.1}, PY32053_00631
GN {ECO:0000313|EMBL:AYF00308.1}, PYTT13_09845
GN {ECO:0000313|EMBL:ATQ56077.1};
OS Paracoccus yeei.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Rhodobacterales;
OC Paracoccaceae; Paracoccus.
OX NCBI_TaxID=147645 {ECO:0000313|EMBL:ARC37458.1, ECO:0000313|Proteomes:UP000191257};
RN [1] {ECO:0000313|Proteomes:UP000191257}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FDAARGOS_252 {ECO:0000313|Proteomes:UP000191257};
RA Minogue T., Wolcott M., Wasieloski L., Aguilar W., Moore D., Tallon L.,
RA Sadzewicz L., Sengamalay N., Ott S., Godinez A., Nagaraj S., Nadendla S.,
RA Geyer C., Sichtig H.;
RT "FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS):
RT Supporting development and validation of Infectious Disease Dx tests.";
RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:ATQ56077.1, ECO:0000313|Proteomes:UP000229314}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TT13 {ECO:0000313|EMBL:ATQ56077.1,
RC ECO:0000313|Proteomes:UP000229314};
RA Lee K., Lim J.Y., Hwang I.;
RT "Complete genome sequence of Paracoccus yeei TT13 isolated from human
RT skin.";
RL Submitted (OCT-2017) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:ARC37458.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=FDAARGOS_252 {ECO:0000313|EMBL:ARC37458.1};
RA Campos J., Goldberg B., Tallon L., Sadzewicz L., Sengamalay N., Ott S.,
RA Godinez A., Nagaraj S., Vyas G., Aluvathingal J., Nadendla S., Geyer C.,
RA Nandy P., Hobson J., Sichtig H.;
RT "FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS):
RT Supporting development and validation of Infectious Disease Dx tests.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:AYF00308.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=CCUG 32053 {ECO:0000313|EMBL:AYF00308.1};
RX PubMed=30410477; DOI=10.3389/fmicb.2018.02553;
RA Lasek R., Szuplewska M., Mitura M., Decewicz P., Chmielowska C., Pawlot A.,
RA Sentkowska D., Czarnecki J., Bartosik D.;
RT "Genome Structure of the Opportunistic Pathogen Paracoccus yeei
RT (Alphaproteobacteria) and Identification of Putative Virulence Factors.";
RL Front. Microbiol. 9:2553-2553(2018).
RN [5] {ECO:0000313|Proteomes:UP000272010}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCUG 32053 {ECO:0000313|Proteomes:UP000272010};
RA Lasek R., Szuplewska M., Mitura M., Decewicz P., Chmielowska C., Pawlot A.,
RA Sentkowska D., Czarnecki J., Bartosik D.;
RT "Genome Structure of the Opportunistic Pathogen Paracoccus yeei
RT (Alphaproteobacteria) and Identification of Putative Virulence Factors.";
RL Submitted (JUL-2018) to the EMBL/GenBank/DDBJ databases.
RN [6] {ECO:0000313|EMBL:QEU08097.1, ECO:0000313|Proteomes:UP000324507}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FDAARGOS_643 {ECO:0000313|EMBL:QEU08097.1,
RC ECO:0000313|Proteomes:UP000324507};
RA Sciortino C., Tallon L., Sadzewicz L., Vavikolanu K., Mehta A.,
RA Aluvathingal J., Nadendla S., Nandy P., Geyer C., Yan Y., Sichtig H.;
RT "FDA dAtabase for Regulatory Grade micrObial Sequences (FDA-ARGOS):
RT Supporting development and validation of Infectious Disease Dx tests.";
RL Submitted (SEP-2019) to the EMBL/GenBank/DDBJ databases.
RN [7] {ECO:0000313|EMBL:MBY0135366.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=S/N-202-OC-B2 {ECO:0000313|EMBL:MBY0135366.1};
RA Seuylemezian A., Singh N.K., Wood J., Venkateswaran K.;
RT "Fungal Genomes of the International Space Station.";
RL Submitted (AUG-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SIMILARITY: Belongs to the peptidase M16 family.
CC {ECO:0000256|ARBA:ARBA00007261, ECO:0000256|RuleBase:RU004447}.
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DR EMBL; CP020442; ARC37458.1; -; Genomic_DNA.
DR EMBL; CP024422; ATQ56077.1; -; Genomic_DNA.
DR EMBL; CP031078; AYF00308.1; -; Genomic_DNA.
DR EMBL; JACLBQ010000018; MBY0135366.1; -; Genomic_DNA.
DR EMBL; CP044081; QEU08097.1; -; Genomic_DNA.
DR STRING; 147645.A6J80_14755; -.
DR KEGG; pye:A6J80_14755; -.
DR eggNOG; COG0612; Bacteria.
DR Proteomes; UP000191257; Chromosome.
DR Proteomes; UP000229314; Chromosome.
DR Proteomes; UP000272010; Chromosome.
DR Proteomes; UP000324507; Chromosome.
DR Proteomes; UP000756578; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:UniProtKB-EC.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 3.30.830.10; Metalloenzyme, LuxS/M16 peptidase-like; 2.
DR InterPro; IPR011249; Metalloenz_LuxS/M16.
DR InterPro; IPR011765; Pept_M16_N.
DR InterPro; IPR001431; Pept_M16_Zn_BS.
DR InterPro; IPR007863; Peptidase_M16_C.
DR PANTHER; PTHR11851:SF149; GH01077P; 1.
DR PANTHER; PTHR11851; METALLOPROTEASE; 1.
DR Pfam; PF00675; Peptidase_M16; 1.
DR Pfam; PF05193; Peptidase_M16_C; 1.
DR SUPFAM; SSF63411; LuxS/MPP-like metallohydrolase; 2.
DR PROSITE; PS00143; INSULINASE; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000313|EMBL:AYF00308.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000191257}.
FT DOMAIN 14..161
FT /note="Peptidase M16 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00675"
FT DOMAIN 168..339
FT /note="Peptidase M16 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05193"
SQ SEQUENCE 421 AA; 46137 MW; BD55A5EB73A22CCC CRC64;
MNQTRISTLP NGLRVVTRDM PGLHSAAIGI WVNAGCRDER AEQNGIAHFL EHMAFKGTPT
RTPLEIAEAI ENVGGYINAY TSRDVTSYYA RVLAGDVGMA LDVISDIVLN PIFDAREIEV
ERGVILQEIG QSLDTPDDVI FDWLQEAAYP DQPMGRTILG PAERVSHFSR DDLSGFIGEH
YGPERMIVSA AGAVDHDRVL RQVEAIFGHL APRARTAREP ARWQGAETRR VKKLEQAHFA
LAFEGPGYQD PDFYAAQIWT SALGGGMSSR LFQKVREERG LCYSIFAQSG FHDDTGMVTV
YAGTSGDQVG DLANITIDEI RRSAEDMTEA EIARARAQLK AGLLMGLESP TGQAERMARS
LAIWGRVSEP AEVAARIDAV TVEDVRDHAQ RLIANARPAL ALYGPVRAAP SRDRLAERLA
A
//
