ID   A0A1V1VYX2_9ACTN        Unreviewed;       280 AA.
AC   A0A1V1VYX2;
DT   07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT   07-JUN-2017, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=Aldo/keto reductase {ECO:0000313|EMBL:GAW53350.1};
GN   ORFNames=PD653_0749 {ECO:0000313|EMBL:GAW53350.1};
OS   Nocardioides sp. PD653.
OC   Bacteria; Actinomycetota; Actinomycetes; Propionibacteriales;
OC   Nocardioidaceae; Nocardioides.
OX   NCBI_TaxID=393303 {ECO:0000313|EMBL:GAW53350.1, ECO:0000313|Proteomes:UP000194147};
RN   [1] {ECO:0000313|Proteomes:UP000194147}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PD653 {ECO:0000313|Proteomes:UP000194147};
RA   Ito K., Takagi K., Tanaka N., Kanesaki Y., Iwasaki A.;
RT   "Nocardioides sp. PD653 draft genome sequence.";
RL   Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:GAW53350.1}.
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DR   EMBL; BDJG01000008; GAW53350.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1V1VYX2; -.
DR   OrthoDB; 9804790at2; -.
DR   Proteomes; UP000194147; Unassembled WGS sequence.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   GO; GO:0071704; P:organic substance metabolic process; IEA:UniProt.
DR   GO; GO:0044281; P:small molecule metabolic process; IEA:UniProt.
DR   CDD; cd19132; AKR_AKR5D1_E1; 1.
DR   Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR   InterPro; IPR020471; AKR.
DR   InterPro; IPR018170; Aldo/ket_reductase_CS.
DR   InterPro; IPR023210; NADP_OxRdtase_dom.
DR   InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR   PANTHER; PTHR43827; 2,5-DIKETO-D-GLUCONIC ACID REDUCTASE; 1.
DR   PANTHER; PTHR43827:SF3; ALDO-KETO REDUCTASE; 1.
DR   Pfam; PF00248; Aldo_ket_red; 2.
DR   PIRSF; PIRSF000097; AKR; 2.
DR   PRINTS; PR00069; ALDKETRDTASE.
DR   SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
DR   PROSITE; PS00798; ALDOKETO_REDUCTASE_1; 1.
DR   PROSITE; PS00062; ALDOKETO_REDUCTASE_2; 1.
DR   PROSITE; PS00063; ALDOKETO_REDUCTASE_3; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000194147}.
FT   DOMAIN          19..194
FT                   /note="NADP-dependent oxidoreductase"
FT                   /evidence="ECO:0000259|Pfam:PF00248"
FT   DOMAIN          204..262
FT                   /note="NADP-dependent oxidoreductase"
FT                   /evidence="ECO:0000259|Pfam:PF00248"
FT   ACT_SITE        52
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-1"
FT   BINDING         110
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-2"
FT   SITE            77
FT                   /note="Lowers pKa of active site Tyr"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
SQ   SEQUENCE   280 AA;  31037 MW;  1793BFD18AC8C7BD CRC64;
     MASDIPTHTL NDGHTLPAIG FGTYPLKDED GIEAVRSAIE NGYRLIDTAV NYENEREVGE
     AIRRSGVPRD QLQVASKIPG RDHGYDDAIA SVHGSLERLG LDYLDLHLIH WPNPRIGQYV
     EAWRALVDLR EQGLVRSIGV SNFTPEHLER IIDETGVTPA VNQVELHPYF PQSVMRDVNT
     KYGIQTESWS PLGKRQAPFS EPPVAEAAEK HGVTPGQVIL RWQVQLGSIP IPKSATPERQ
     RQNLDVFGFE LSDDEVAAIT ALGRPTGRLF GGDPDTHEEM
//