ID A0A1V2EVG4_9SPHN Unreviewed; 459 AA.
AC A0A1V2EVG4;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Macrolide export protein MacA {ECO:0000313|EMBL:ONF96465.1};
GN Name=macA {ECO:0000313|EMBL:ONF96465.1};
GN ORFNames=SPHI_12500 {ECO:0000313|EMBL:ONF96465.1};
OS Sphingomonas jeddahensis.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Sphingomonadaceae; Sphingomonas.
OX NCBI_TaxID=1915074 {ECO:0000313|EMBL:ONF96465.1, ECO:0000313|Proteomes:UP000188729};
RN [1] {ECO:0000313|EMBL:ONF96465.1, ECO:0000313|Proteomes:UP000188729}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=G39 {ECO:0000313|EMBL:ONF96465.1,
RC ECO:0000313|Proteomes:UP000188729};
RA Poehlein A., Wuebbeler J.H., Steinbuechel A., Daniel R.;
RT "Genome sequence of Sphingomonas jeddahensis G39.";
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC family. {ECO:0000256|ARBA:ARBA00009477}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ONF96465.1}.
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DR EMBL; MPSB01000004; ONF96465.1; -; Genomic_DNA.
DR RefSeq; WP_076744030.1; NZ_MPSB01000004.1.
DR AlphaFoldDB; A0A1V2EVG4; -.
DR STRING; 1915074.SPHI_12500; -.
DR OrthoDB; 9791520at2; -.
DR Proteomes; UP000188729; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 2.40.30.170; -; 1.
DR Gene3D; 2.40.420.20; -; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 1.10.287.470; Helix hairpin bin; 1.
DR InterPro; IPR032317; HlyD_D23.
DR InterPro; IPR006143; RND_pump_MFP.
DR NCBIfam; TIGR01730; RND_mfp; 1.
DR PANTHER; PTHR32347; EFFLUX SYSTEM COMPONENT YKNX-RELATED; 1.
DR PANTHER; PTHR32347:SF14; EFFLUX SYSTEM COMPONENT YKNX-RELATED; 1.
DR Pfam; PF16576; HlyD_D23; 1.
DR SUPFAM; SSF111369; HlyD-like secretion proteins; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000188729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 21..42
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 61..280
FT /note="RND efflux pump membrane fusion protein barrel-
FT sandwich"
FT /evidence="ECO:0000259|Pfam:PF16576"
FT REGION 357..381
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 438..459
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 129..197
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 459 AA; 47548 MW; E2F16C27F066E897 CRC64;
MATPDTDEFL GVKAQPAWRR WVKWVAIGVG VLLLILLGLR LFGSKEAAGF ATAPVRRGDL
TVTVSATGKL APTNQVTVGS QLSGLVTRVV VDVNDRVTAG QALALIDPEQ IDDQIRAGQA
QLAANVASVN QARATVSEAQ AQLARLEEVY RLSNGRVPSK TELQTGRANA QRAVAALRVA
EANVQAARAN LSQNQTQRQR AIIVSPVNGV VLARQVDPGQ TVAASFNTPT LFVIAEDLSK
MKLEVAIDEA DVGSVKEGQK ADFTVDAFPG RTFPATITRV DLGSNLTAST ASSSSSSTTG
ATSTTGQVVS YAADLTVANP TMELRPGMTA TADIVTSDKK NVLLVPNAAF RFKPAPAAGA
GESGGIAGSL TFRPRRGDRP ERTATLGRGA QQTLYIKGAD GQPQAVQVTT GDTNGSVTEV
LSGGLKPGME VITGQLSGEE GAAAKSGQRR QRQGGAGGA
//
