ID A0A1V2I3Q9_9ACTN Unreviewed; 739 AA.
AC A0A1V2I3Q9;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase {ECO:0000256|ARBA:ARBA00012519};
DE EC=2.7.7.70 {ECO:0000256|ARBA:ARBA00012519};
GN ORFNames=BL253_32360 {ECO:0000313|EMBL:ONH23673.1};
OS Pseudofrankia asymbiotica.
OC Bacteria; Actinomycetota; Actinomycetes; Frankiales; Frankiaceae;
OC Pseudofrankia.
OX NCBI_TaxID=1834516 {ECO:0000313|EMBL:ONH23673.1, ECO:0000313|Proteomes:UP000188929};
RN [1] {ECO:0000313|Proteomes:UP000188929}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL B-16386 {ECO:0000313|Proteomes:UP000188929};
RA Ghodhbane-Gtari F., Swanson E., Gueddou A., Hezbri K., Ktari K.,
RA Nouioui I., Morris K., Simpson S., Abebe-Akele F., Thomas K., Gtari M.,
RA Tisa L.S.;
RT "Frankia sp. NRRL B-16386 Genome sequencing.";
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + D-glycero-beta-D-manno-heptose 1-phosphate + H(+) = ADP-
CC D-glycero-beta-D-manno-heptose + diphosphate; Xref=Rhea:RHEA:27465,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019,
CC ChEBI:CHEBI:59967, ChEBI:CHEBI:61593; EC=2.7.7.70;
CC Evidence={ECO:0000256|ARBA:ARBA00000534};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ONH23673.1}.
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DR EMBL; MOMC01000082; ONH23673.1; -; Genomic_DNA.
DR STRING; 1834516.BL253_32360; -.
DR Proteomes; UP000188929; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR GO; GO:0016779; F:nucleotidyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0016773; F:phosphotransferase activity, alcohol group as acceptor; IEA:InterPro.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR GO; GO:1901135; P:carbohydrate derivative metabolic process; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-KW.
DR CDD; cd05006; SIS_GmhA; 1.
DR Gene3D; 3.40.1190.20; -; 1.
DR Gene3D; 3.40.50.620; HUPs; 1.
DR InterPro; IPR004821; Cyt_trans-like.
DR InterPro; IPR035461; GmhA/DiaA.
DR InterPro; IPR011611; PfkB_dom.
DR InterPro; IPR011914; RfaE_dom_II.
DR InterPro; IPR029056; Ribokinase-like.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR001347; SIS_dom.
DR InterPro; IPR046348; SIS_dom_sf.
DR NCBIfam; TIGR00125; cyt_tran_rel; 1.
DR NCBIfam; TIGR02199; rfaE_dom_II; 1.
DR PANTHER; PTHR30390:SF6; DNAA INITIATOR-ASSOCIATING PROTEIN DIAA; 1.
DR PANTHER; PTHR30390; SEDOHEPTULOSE 7-PHOSPHATE ISOMERASE / DNAA INITIATOR-ASSOCIATING FACTOR FOR REPLICATION INITIATION; 1.
DR Pfam; PF01467; CTP_transf_like; 1.
DR Pfam; PF00294; PfkB; 1.
DR Pfam; PF13580; SIS_2; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR SUPFAM; SSF53613; Ribokinase-like; 1.
DR SUPFAM; SSF53697; SIS domain; 1.
DR PROSITE; PS51464; SIS; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00023277};
KW Isomerase {ECO:0000313|EMBL:ONH23673.1};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Reference proteome {ECO:0000313|Proteomes:UP000188929};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 16..173
FT /note="SIS"
FT /evidence="ECO:0000259|PROSITE:PS51464"
SQ SEQUENCE 739 AA; 75520 MW; BBD3C43F57238059 CRC64;
MDQLDVARLE DWGRRLAEVL PGGGRLLVAG NGGSAAEAQH LTAELVGRFQ DERAPMSAIA
LHAETSALTA IGNDYGYDEV FARQVRAHGR PGDVLVVLST SGRSANLVRA VDAARELGLR
TWGLVGVADS PLARRCDETV VASLDTPSTA TVQETHLVAV HLLCAAFDTA LADATMAGTS
TAPDAAEPVA AELAETELAE TEXPRVPASW PGGRPLVVVG DTLLDVDVDG RVERLVPGAP
APVFDAIADH PRPGGAGLAA LLAARAGHRV MLVTALGADA AGRRVAALLA AEGIELVDLG
LRGPTPRKIR FQAGGQTMLR LDRACAPPGD RRDRRAGAER SGAERGAFVG ALPAEGRRAL
AVAGAVLVSD YGRGLAAATS VRAALTERLG RVPVVWDPHP RGGAPLPGVR MVTPNLMEAR
QFTADGDEPG GTASARGDVV SEAAERGRRL VGSWRAATAA VTLGERGALL VDASGAPPLV
VLPASAATGD TCGAGDMFAV TAAAALAGGA LPSEAIVAAT DAASVFVAAG AASAVRIDTS
RIDTGPMDGD ALDLALDADA LALDAALDAX GTESGRGAAV AYRDSGLEQA LAVVRRTREA
GGTVVATGGC FDLLHAGHVE VLAAARQLGD CLVVCLNSDD SVRRLKGPQR PLVPAGDRAA
VLRGLGSVDA VAVFDEDTPA RLLAELRPDI FAKGGDYAVA DLPEAEVVAS WHGQAVVLPY
LDGRSTTSII REAVHRDGR
//
