ID A0A1V2I9B9_9ACTN Unreviewed; 376 AA.
AC A0A1V2I9B9;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE SubName: Full=Uroporphyrinogen-III synthase {ECO:0000313|EMBL:ONH29159.1};
GN ORFNames=BL253_17250 {ECO:0000313|EMBL:ONH29159.1};
OS Pseudofrankia asymbiotica.
OC Bacteria; Actinomycetota; Actinomycetes; Frankiales; Frankiaceae;
OC Pseudofrankia.
OX NCBI_TaxID=1834516 {ECO:0000313|EMBL:ONH29159.1, ECO:0000313|Proteomes:UP000188929};
RN [1] {ECO:0000313|Proteomes:UP000188929}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL B-16386 {ECO:0000313|Proteomes:UP000188929};
RA Ghodhbane-Gtari F., Swanson E., Gueddou A., Hezbri K., Ktari K.,
RA Nouioui I., Morris K., Simpson S., Abebe-Akele F., Thomas K., Gtari M.,
RA Tisa L.S.;
RT "Frankia sp. NRRL B-16386 Genome sequencing.";
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ONH29159.1}.
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DR EMBL; MOMC01000034; ONH29159.1; -; Genomic_DNA.
DR RefSeq; WP_076818191.1; NZ_MOMC01000034.1.
DR AlphaFoldDB; A0A1V2I9B9; -.
DR STRING; 1834516.BL253_17250; -.
DR OrthoDB; 213853at2; -.
DR Proteomes; UP000188929; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004852; F:uroporphyrinogen-III synthase activity; IEA:InterPro.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR GO; GO:0006780; P:uroporphyrinogen III biosynthetic process; IEA:InterPro.
DR CDD; cd06578; HemD; 1.
DR CDD; cd00383; trans_reg_C; 1.
DR Gene3D; 3.40.50.10090; -; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR036108; 4pyrrol_syn_uPrphyn_synt_sf.
DR InterPro; IPR003754; 4pyrrol_synth_uPrphyn_synth.
DR InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR InterPro; IPR039793; UROS/Hem4.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR40082; BLR5956 PROTEIN; 1.
DR PANTHER; PTHR40082:SF1; BLR5956 PROTEIN; 1.
DR Pfam; PF02602; HEM4; 1.
DR Pfam; PF00486; Trans_reg_C; 1.
DR SMART; SM00862; Trans_reg_C; 1.
DR SUPFAM; SSF46894; C-terminal effector domain of the bipartite response regulators; 1.
DR SUPFAM; SSF69618; HemD-like; 1.
DR PROSITE; PS51755; OMPR_PHOB; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU01091};
KW Reference proteome {ECO:0000313|Proteomes:UP000188929}.
FT DOMAIN 279..375
FT /note="OmpR/PhoB-type"
FT /evidence="ECO:0000259|PROSITE:PS51755"
FT DNA_BIND 279..375
FT /note="OmpR/PhoB-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01091"
SQ SEQUENCE 376 AA; 39185 MW; 16E47C7DBAD42EFE CRC64;
MSAPDPGPVP PLLGFTIGLT AARRRDELAS LLERRGAKVV QAPALRIVPL EDDGRLLEAT
RACLAAPLDA VVATTGIGFR GWMEAAHGWG LGDELSGGLA AARLFTRGPK VTGAVRAAGL
SECWSPLSES GAELLDHLLG QDLRGKRIAV QLHGEPLPGM VDGLRAAGAD VVEVPVYRWE
PPEDARPVRR LVEQVVSGGV DALAFTSAPA VASLLATATE LGQREALIEA MSGPVLAACV
GPVCAGPLRH LGIPTVHPER FRLGALVRTI CEELPARRAR EVDAGGHRLR VQGCAVVVDG
GRPVMLAPKA AAVLVALAER PGRVLSRAEL LTRTGAGAGA DEHAMEMTVA RLRTALGPAG
RAIETVLKRG YRLAVG
//
