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Database: UniProt
Entry: A0A1V2L090_CYBFA
LinkDB: A0A1V2L090_CYBFA
Original site: A0A1V2L090_CYBFA 
ID   A0A1V2L090_CYBFA        Unreviewed;       944 AA.
AC   A0A1V2L090;
DT   07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT   07-JUN-2017, sequence version 1.
DT   24-JAN-2024, entry version 27.
DE   RecName: Full=lanosterol synthase {ECO:0000256|ARBA:ARBA00029485};
DE            EC=5.4.99.7 {ECO:0000256|ARBA:ARBA00029485};
GN   ORFNames=BON22_5082 {ECO:0000313|EMBL:ONH64995.1};
OS   Cyberlindnera fabianii (Yeast) (Hansenula fabianii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Phaffomycetaceae; Cyberlindnera.
OX   NCBI_TaxID=36022 {ECO:0000313|EMBL:ONH64995.1, ECO:0000313|Proteomes:UP000189513};
RN   [1] {ECO:0000313|Proteomes:UP000189513}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=65 {ECO:0000313|Proteomes:UP000189513};
RX   PubMed=28385833; DOI=10.1128/genomeA.00064-17;
RA   van Rijswijck I.M.H., Derks M.F.L., Abee T., de Ridder D., Smid E.J.;
RT   "Genome sequences of Cyberlindnera fabianii 65, Pichia kudriavzevii 129,
RT   and Saccharomyces cerevisiae 131 isolated from fermented masau fruits in
RT   Zimbabwe.";
RL   Genome Announc. 5:E00064-E00064(2017).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the YIP1 family.
CC       {ECO:0000256|ARBA:ARBA00010596}.
CC   -!- SIMILARITY: Belongs to the terpene cyclase/mutase family.
CC       {ECO:0000256|ARBA:ARBA00009755}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ONH64995.1}.
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DR   EMBL; MPUK01000014; ONH64995.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1V2L090; -.
DR   STRING; 36022.A0A1V2L090; -.
DR   VEuPathDB; FungiDB:BON22_5082; -.
DR   OMA; CWARQTI; -.
DR   OrthoDB; 2712461at2759; -.
DR   Proteomes; UP000189513; Unassembled WGS sequence.
DR   GO; GO:0005811; C:lipid droplet; IEA:InterPro.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016866; F:intramolecular transferase activity; IEA:InterPro.
DR   GO; GO:0016104; P:triterpenoid biosynthetic process; IEA:InterPro.
DR   CDD; cd02892; SQCY_1; 1.
DR   Gene3D; 1.50.10.20; -; 2.
DR   Gene3D; 6.20.120.20; -; 1.
DR   InterPro; IPR032696; SQ_cyclase_C.
DR   InterPro; IPR032697; SQ_cyclase_N.
DR   InterPro; IPR018333; Squalene_cyclase.
DR   InterPro; IPR002365; Terpene_synthase_CS.
DR   InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR   InterPro; IPR006977; Yip1_dom.
DR   NCBIfam; TIGR01787; squalene_cyclas; 1.
DR   PANTHER; PTHR11764:SF20; LANOSTEROL SYNTHASE; 1.
DR   PANTHER; PTHR11764; TERPENE CYCLASE/MUTASE FAMILY MEMBER; 1.
DR   Pfam; PF13243; SQHop_cyclase_C; 1.
DR   Pfam; PF13249; SQHop_cyclase_N; 1.
DR   Pfam; PF04893; Yip1; 1.
DR   SFLD; SFLDG01016; Prenyltransferase_Like_2; 1.
DR   SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 2.
DR   PROSITE; PS01074; TERPENE_SYNTHASES; 1.
PE   3: Inferred from homology;
KW   Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000189513};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        833..851
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        863..883
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        889..913
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        920..940
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          86..271
FT                   /note="Squalene cyclase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13249"
FT   DOMAIN          379..685
FT                   /note="Squalene cyclase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF13243"
FT   DOMAIN          801..936
FT                   /note="Yip1"
FT                   /evidence="ECO:0000259|Pfam:PF04893"
SQ   SEQUENCE   944 AA;  106377 MW;  F76D244273EE55BC CRC64;
     MLYSEELGLP KTDPTRWRLS STDLGRTEWH YLSEEESASN EQSIVEQYLL KTPNFAPPSL
     NPTESALDAA KNGATFLSYI QDTNSGIFPN QYKGPMFMTI GYVASHYATK TPIPEHERTE
     LIRYIVNTAH PVDGGWGLHS VDKSTCFGTT INYVCLRLLG LPADHTVCKR ARVTLRKLGG
     AIRTPHWGKS WLSVLNLYKW EGVNPAPPEL WALPYALPVH PGRWWVHTRA IYLPMGYLAA
     DGFQCEDDEL LQELRREIYT RDYDSIDFSK HRDDVCGVDL YYPHSTMLNL VNPILATWEK
     WRPKWLLNTL KRYIYDIFKK ELINTEHMTI APVSAGFGAL VVYSEEGPDS ETFKTCMARF
     KDCLFHGSQG LTVMGTNGSQ VWDAAFAVQY LFMAGLAELP EYRDMVERSY RFLVRSQFTE
     ECQEGSFRDK RVGGWPFSTK EQGYTVSDCT AEAVKAIIMV QNSPEFANVR DLISAEKLHK
     AVDILLGLQN VGSFEFGSFA TYEKIKATPL LELLNPAEVF ANIMVEYPYV ECTDSVVLGL
     TYFRKYDDYR KPEINVAIDN AISYIKKAQN KDGSWYGCWG ICYTYAGMFA LEALNTIGEN
     YANSEVVKKG CDFLVSRQRL DGGWSESMKA CELHSYVETE QSLVIQTAWA VIGLLLAEYP
     DKKVIKRGID LIMKRQKETG EWVFEDIEGV FNHSCQEPID LEHTFTMAFY NQPDNLQFYP
     TQYDYSAQHT QGVAGQMDTQ YNTGYVAGQM GDDTLSTGIL AAFSTSGYAN EPPLLEEIGI
     NFQHIKQKTL AVLNPRGLIT TDIMNDADLA GPIIFCLVFG LFLLLAGKIH FGYIYGVALM
     GTLSLHFLFG LMSDTSIDLA RTVSVLGYCL LPLLPIGFAG IFIDLNNMLG YIFSSAAIFW
     STYAASGFFV AVLKLDNVRI LIAYPAAMFY SVFVLMAIFV EKDS
//
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