ID A0A1V2L090_CYBFA Unreviewed; 944 AA.
AC A0A1V2L090;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE RecName: Full=lanosterol synthase {ECO:0000256|ARBA:ARBA00029485};
DE EC=5.4.99.7 {ECO:0000256|ARBA:ARBA00029485};
GN ORFNames=BON22_5082 {ECO:0000313|EMBL:ONH64995.1};
OS Cyberlindnera fabianii (Yeast) (Hansenula fabianii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Phaffomycetaceae; Cyberlindnera.
OX NCBI_TaxID=36022 {ECO:0000313|EMBL:ONH64995.1, ECO:0000313|Proteomes:UP000189513};
RN [1] {ECO:0000313|Proteomes:UP000189513}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=65 {ECO:0000313|Proteomes:UP000189513};
RX PubMed=28385833; DOI=10.1128/genomeA.00064-17;
RA van Rijswijck I.M.H., Derks M.F.L., Abee T., de Ridder D., Smid E.J.;
RT "Genome sequences of Cyberlindnera fabianii 65, Pichia kudriavzevii 129,
RT and Saccharomyces cerevisiae 131 isolated from fermented masau fruits in
RT Zimbabwe.";
RL Genome Announc. 5:E00064-E00064(2017).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the YIP1 family.
CC {ECO:0000256|ARBA:ARBA00010596}.
CC -!- SIMILARITY: Belongs to the terpene cyclase/mutase family.
CC {ECO:0000256|ARBA:ARBA00009755}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ONH64995.1}.
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DR EMBL; MPUK01000014; ONH64995.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1V2L090; -.
DR STRING; 36022.A0A1V2L090; -.
DR VEuPathDB; FungiDB:BON22_5082; -.
DR OMA; CWARQTI; -.
DR OrthoDB; 2712461at2759; -.
DR Proteomes; UP000189513; Unassembled WGS sequence.
DR GO; GO:0005811; C:lipid droplet; IEA:InterPro.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016866; F:intramolecular transferase activity; IEA:InterPro.
DR GO; GO:0016104; P:triterpenoid biosynthetic process; IEA:InterPro.
DR CDD; cd02892; SQCY_1; 1.
DR Gene3D; 1.50.10.20; -; 2.
DR Gene3D; 6.20.120.20; -; 1.
DR InterPro; IPR032696; SQ_cyclase_C.
DR InterPro; IPR032697; SQ_cyclase_N.
DR InterPro; IPR018333; Squalene_cyclase.
DR InterPro; IPR002365; Terpene_synthase_CS.
DR InterPro; IPR008930; Terpenoid_cyclase/PrenylTrfase.
DR InterPro; IPR006977; Yip1_dom.
DR NCBIfam; TIGR01787; squalene_cyclas; 1.
DR PANTHER; PTHR11764:SF20; LANOSTEROL SYNTHASE; 1.
DR PANTHER; PTHR11764; TERPENE CYCLASE/MUTASE FAMILY MEMBER; 1.
DR Pfam; PF13243; SQHop_cyclase_C; 1.
DR Pfam; PF13249; SQHop_cyclase_N; 1.
DR Pfam; PF04893; Yip1; 1.
DR SFLD; SFLDG01016; Prenyltransferase_Like_2; 1.
DR SUPFAM; SSF48239; Terpenoid cyclases/Protein prenyltransferases; 2.
DR PROSITE; PS01074; TERPENE_SYNTHASES; 1.
PE 3: Inferred from homology;
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000189513};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 833..851
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 863..883
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 889..913
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 920..940
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 86..271
FT /note="Squalene cyclase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF13249"
FT DOMAIN 379..685
FT /note="Squalene cyclase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13243"
FT DOMAIN 801..936
FT /note="Yip1"
FT /evidence="ECO:0000259|Pfam:PF04893"
SQ SEQUENCE 944 AA; 106377 MW; F76D244273EE55BC CRC64;
MLYSEELGLP KTDPTRWRLS STDLGRTEWH YLSEEESASN EQSIVEQYLL KTPNFAPPSL
NPTESALDAA KNGATFLSYI QDTNSGIFPN QYKGPMFMTI GYVASHYATK TPIPEHERTE
LIRYIVNTAH PVDGGWGLHS VDKSTCFGTT INYVCLRLLG LPADHTVCKR ARVTLRKLGG
AIRTPHWGKS WLSVLNLYKW EGVNPAPPEL WALPYALPVH PGRWWVHTRA IYLPMGYLAA
DGFQCEDDEL LQELRREIYT RDYDSIDFSK HRDDVCGVDL YYPHSTMLNL VNPILATWEK
WRPKWLLNTL KRYIYDIFKK ELINTEHMTI APVSAGFGAL VVYSEEGPDS ETFKTCMARF
KDCLFHGSQG LTVMGTNGSQ VWDAAFAVQY LFMAGLAELP EYRDMVERSY RFLVRSQFTE
ECQEGSFRDK RVGGWPFSTK EQGYTVSDCT AEAVKAIIMV QNSPEFANVR DLISAEKLHK
AVDILLGLQN VGSFEFGSFA TYEKIKATPL LELLNPAEVF ANIMVEYPYV ECTDSVVLGL
TYFRKYDDYR KPEINVAIDN AISYIKKAQN KDGSWYGCWG ICYTYAGMFA LEALNTIGEN
YANSEVVKKG CDFLVSRQRL DGGWSESMKA CELHSYVETE QSLVIQTAWA VIGLLLAEYP
DKKVIKRGID LIMKRQKETG EWVFEDIEGV FNHSCQEPID LEHTFTMAFY NQPDNLQFYP
TQYDYSAQHT QGVAGQMDTQ YNTGYVAGQM GDDTLSTGIL AAFSTSGYAN EPPLLEEIGI
NFQHIKQKTL AVLNPRGLIT TDIMNDADLA GPIIFCLVFG LFLLLAGKIH FGYIYGVALM
GTLSLHFLFG LMSDTSIDLA RTVSVLGYCL LPLLPIGFAG IFIDLNNMLG YIFSSAAIFW
STYAASGFFV AVLKLDNVRI LIAYPAAMFY SVFVLMAIFV EKDS
//