ID   A0A1V2L1F3_CYBFA        Unreviewed;      1780 AA.
AC   A0A1V2L1F3;
DT   07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT   07-JUN-2017, sequence version 1.
DT   27-MAR-2024, entry version 25.
DE   SubName: Full=Phosphatidylinositol 4-kinase STT4 {ECO:0000313|EMBL:ONH65600.1};
GN   ORFNames=BON22_4562 {ECO:0000313|EMBL:ONH65600.1};
OS   Cyberlindnera fabianii (Yeast) (Hansenula fabianii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Phaffomycetaceae; Cyberlindnera.
OX   NCBI_TaxID=36022 {ECO:0000313|EMBL:ONH65600.1, ECO:0000313|Proteomes:UP000189513};
RN   [1] {ECO:0000313|Proteomes:UP000189513}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=65 {ECO:0000313|Proteomes:UP000189513};
RX   PubMed=28385833; DOI=10.1128/genomeA.00064-17;
RA   van Rijswijck I.M.H., Derks M.F.L., Abee T., de Ridder D., Smid E.J.;
RT   "Genome sequences of Cyberlindnera fabianii 65, Pichia kudriavzevii 129,
RT   and Saccharomyces cerevisiae 131 isolated from fermented masau fruits in
RT   Zimbabwe.";
RL   Genome Announc. 5:E00064-E00064(2017).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ONH65600.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; MPUK01000010; ONH65600.1; -; Genomic_DNA.
DR   STRING; 36022.A0A1V2L1F3; -.
DR   VEuPathDB; FungiDB:BON22_4562; -.
DR   OMA; CCHRIES; -.
DR   OrthoDB; 147843at2759; -.
DR   Proteomes; UP000189513; Unassembled WGS sequence.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:InterPro.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd05167; PI4Kc_III_alpha; 1.
DR   Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR   InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR   InterPro; IPR018936; PI3/4_kinase_CS.
DR   InterPro; IPR015433; PI_Kinase.
DR   PANTHER; PTHR10048:SF15; PHOSPHATIDYLINOSITOL 4-KINASE ALPHA; 1.
DR   PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR   Pfam; PF00454; PI3_PI4_kinase; 1.
DR   SMART; SM00146; PI3Kc; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR   PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR   PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE   4: Predicted;
KW   Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:ONH65600.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000189513};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          1486..1764
FT                   /note="PI3K/PI4K catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS50290"
SQ   SEQUENCE   1780 AA;  199414 MW;  76C961056749D26C CRC64;
     MTNSIRIPRG SIRSQALNRV AALSLKGPVE HAVSAVNGSA TNGHINGSAN GTLNGSAKVT
     PCTGLPGDLL KLANAVARED VSSVAISHKE LEIIFALCNA APAVRTEQQA SDLIAVLSPY
     FLESSSQKFK SHASLQLGPS PWDHLTKTLA DAMIALTNKY ASLSTKTETS FKQFLSKFSL
     QEEQPLTAYF SLLGFLKSLI STPSLLDQSM TQIIVELFNA EFLDRLESVT MKALEDEHDF
     TYLLAYKATN DEFNSLLFAH LVQKFFNRVL LTLASRDFEN ISPQESDTGL IGHLLLVNSP
     DYDDEPDVTS QLDKLKTIFS RHIELIKVLC RKSSAQIDEL DHGSTYINIS SPERVTLAMR
     TKGLALQVLA AGLVADIIPS DIMTETVRSS LAHPSEAVDT HISPVVISIG ALLTYKGQKV
     IISDLIHSFP LLVSKITPDA STAFVKIISK CFALGLKPLD EDSIVTTIYS LVNLLVSENG
     APVNALRELR LRSATNTFNS KTRASRSNTL YKLVQTESAT SLKEQTSENS HVFRNAITSA
     LEIAKVYDDD SITVLTVTIL SQKFLTVSRE LDFYLLDGLS DIATHVSEKE FLALLKSFDA
     GMYRDDKDQS FINAIVATRV KIAKALEGKF SHPLHDVYIT ELLQSVVALG DVQNKDHRSQ
     GEISEIAVKI ARYIPPLAQL LPKGEKLEPL SNSMVALFQN FWFNIAVHGY SETAKLTKQL
     QKFLEVIALN SPPLASDAAR AHTEASFELN TVLRRGSSNH NVKDQQHIIA GVSNTNSLEL
     KTLSYSKLMF LSATSLLENL RANIGDCSTI LHYFADPAIS KANIEKFIGS IAISVVQKFS
     KLTITAHSPY FTSDNAAAQL TKILILCVHR NYDLQDAAFQ CATALMHKLP TTLCNRTSLY
     TLLDLLTTMY ESHLDAERSK YQPQRELTLR HSKVKITVSD SVKWKRSTLD KLIKKAEEWC
     HLSLIKCNQD MRTLLMTYVS DLALFNELSP VDFGISFALR MAGTILSGDA QSSSIVKTNA
     LAGFLTEYRW KAQNLGKTRG ELDDYAADPN EHPLLTAIRA QKRALSFESE WTKRIGLSDQ
     ESREDLSYML FAEIVVGWQR CLSLHEGLFS RKHDLKDEGF LKMEYIPSDQ AKVDYYANLV
     IKNLEVDTQV ISFLASHFQG TLYQSEHMLH MFTDVVFDAL EHLKVASLHP YARAVRFKMI
     KFALDVLAAH FKIGSKIVSK LFDAILDGAL SWFVQYRPYP FGDNDLKIRA DMDLMIDVFD
     ELRSLTIPAG RSSRVDQKRR LLLTFLFDEI NKSMIWLSPR DPVEFKGEVY KADSKVLAFA
     YKLDPSLAFS LVARTPGLEK DIATLVTQSP SKALSHYQSV QYLLKDSRLS RYLILAQPIS
     PTESINLFTP PYINDPYVTQ YTMRALEAQD INLTFFYVPQ IAKAYYDREF GFFNEVTDIS
     GKLRPYLKNT KAEKKVKIDE EMAKIVVLDD VYLPSNPDGV VVDINRTSGK PLQSHAKTPF
     MATFRIRKDQ LVNGRMLTVE KWQSAIFKVG DDVRQDVLAL QLIAIFKSVW ENAGLDMYCF
     PNRVTATAPG CGVIDVLPNS ISRDMLGREA VNDLYTYFKA KFPDGNLEFE DAVQNFVKSL
     AAYSIISYLL QFKDRHNGNI MYDDKGHILH IDFGFCFDIV PGGVKFEACP FKLTKEMVRV
     MGGSNNTEYF HMFEELFIKG FLAMRPHHEL IIGNVQSMLA SGLPCFKGEK TIRNLRHRFF
     LNKNDKECIK ALKGLIRESY ESIFSVGYDK FQKMTNGIPY
//