ID   A0A1V2L5A9_CYBFA        Unreviewed;      1041 AA.
AC   A0A1V2L5A9;
DT   07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT   07-JUN-2017, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Endocytosis protein end4 {ECO:0000313|EMBL:ONH67097.1};
GN   ORFNames=BON22_3099 {ECO:0000313|EMBL:ONH67097.1};
OS   Cyberlindnera fabianii (Yeast) (Hansenula fabianii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Phaffomycetaceae; Cyberlindnera.
OX   NCBI_TaxID=36022 {ECO:0000313|EMBL:ONH67097.1, ECO:0000313|Proteomes:UP000189513};
RN   [1] {ECO:0000313|Proteomes:UP000189513}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=65 {ECO:0000313|Proteomes:UP000189513};
RX   PubMed=28385833; DOI=10.1128/genomeA.00064-17;
RA   van Rijswijck I.M.H., Derks M.F.L., Abee T., de Ridder D., Smid E.J.;
RT   "Genome sequences of Cyberlindnera fabianii 65, Pichia kudriavzevii 129,
RT   and Saccharomyces cerevisiae 131 isolated from fermented masau fruits in
RT   Zimbabwe.";
RL   Genome Announc. 5:E00064-E00064(2017).
CC   -!- SIMILARITY: Belongs to the SLA2 family.
CC       {ECO:0000256|ARBA:ARBA00010135}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ONH67097.1}.
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DR   EMBL; MPUK01000005; ONH67097.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1V2L5A9; -.
DR   STRING; 36022.A0A1V2L5A9; -.
DR   VEuPathDB; FungiDB:BON22_3099; -.
DR   OMA; NREMSDL; -.
DR   OrthoDB; 7775at2759; -.
DR   Proteomes; UP000189513; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   GO; GO:0030276; F:clathrin binding; IEA:InterPro.
DR   GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR   GO; GO:0006897; P:endocytosis; IEA:InterPro.
DR   CDD; cd17007; ANTH_N_Sla2p; 1.
DR   Gene3D; 1.25.40.90; -; 1.
DR   Gene3D; 1.20.1410.10; I/LWEQ domain; 1.
DR   InterPro; IPR011417; ANTH_dom.
DR   InterPro; IPR013809; ENTH.
DR   InterPro; IPR008942; ENTH_VHS.
DR   InterPro; IPR035964; I/LWEQ_dom_sf.
DR   InterPro; IPR002558; ILWEQ_dom.
DR   InterPro; IPR030224; Sla2_fam.
DR   PANTHER; PTHR10407; HUNTINGTIN INTERACTING PROTEIN 1; 1.
DR   PANTHER; PTHR10407:SF15; HUNTINGTIN INTERACTING PROTEIN 1; 1.
DR   Pfam; PF07651; ANTH; 1.
DR   Pfam; PF01608; I_LWEQ; 1.
DR   SMART; SM00273; ENTH; 1.
DR   SMART; SM00307; ILWEQ; 1.
DR   SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR   SUPFAM; SSF109885; I/LWEQ domain; 1.
DR   PROSITE; PS50942; ENTH; 1.
DR   PROSITE; PS50945; I_LWEQ; 1.
PE   3: Inferred from homology;
KW   Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Reference proteome {ECO:0000313|Proteomes:UP000189513}.
FT   DOMAIN          2..131
FT                   /note="ENTH"
FT                   /evidence="ECO:0000259|PROSITE:PS50942"
FT   DOMAIN          795..1036
FT                   /note="I/LWEQ"
FT                   /evidence="ECO:0000259|PROSITE:PS50945"
FT   REGION          261..289
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          322..617
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COILED          995..1024
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1041 AA;  116806 MW;  22ED7BB530D4492C CRC64;
     MSKTISDSDL ISSLKKATSL DETAPKRKHV RACIVYTWDH KSSRQFFNQL KLLPVQGDEV
     QLFKTLITIH KVLQEGHGSA LKEAMRNADW IEGLGRSVHG DGFKGYGRLI KEYVVYLLRK
     LNFHKNHRGF NGTFEYEEYV SLVTVQNPDE GYEAILDLMT LQDALDDLQR LIFASISHDR
     KSECKISALV PLVAESYGIY KFITSMLRAI HRSTGSDEAL EPLRERYESQ HARLYEFYAD
     CSSIRYLTSL ITIPRLPETA PNLISKDESD VESERPASRQ TSVATPVPEP ISEQPTMGNF
     QQPIASQPTG VDFWNTQQNV FEAEQQRLAR EAQENMLQQQ QQAEQQRIWF EQQQAAQAEQ
     QRLAQEQLLR DQLQNQAEGR VAELERDLLA MRQQYETDQL LLQQYDQRVK TLEQEIATTT
     QTATQQLGSK DELLNSLQEQ LTLWKNKYDS LAKLYSQLRQ EHLNLLNKFK KLQQKAASAQ
     EAIERREKLE KDLKSKNVEL AGLIRERDRA RLDLEKIKGG KDSEIDKLEL QIRDLTLKLD
     DSERSQSSNL SSVFASHKRE MEDLKAKLET QSRALNPDLE QKLKEKEEEL EIVQQTMDDA
     LQELARVQGE NDEAINEQLD AVLIDHLTKL TSLVDAILAS GIKRIQDSLY ELDSPMQAGN
     QNSSPEYLLS IIEKAQSSAT DFANSFNDFI ADGPNGDHSE IIRSINEFTS SIADVLLNAK
     GIVRLVKTDS ESNQLIAASR STAQESEDFL MSLLSDILEG TEEEKTEVVI SGNLNVQEKL
     QELIVIAENL APRSVLKNIN GDLGDAVDNE LNSAASAITS AAAHLKDLLN SSFDSSIDGD
     INKAILSAAI SVTNSIALLI QAAIETQNEI VTKNQGSGTR AQFYKKHNRW TEGLISAAKA
     VAASTKILIG TADGVLSSKN THEELIVASN EVAASTAQLV AASRVKATFM SKTQDTLENA
     SKTVTSACRS LVNQVQDILN QRTNGGDQDI DFSKLTNHEN KTMEMEQQVE ILKLENALAS
     ARKRLGEIRK YGYRDGDSDE E
//